ZYNYZ

Indicated For

Merkel cell carcinoma (MCC), squamous cell carcinoma of the anal canal (SCAC), MSI-H CRC

About This Medication

# IncyteCARES for ZYNYZ Patient Assistance Program Patient Guide: How to Get ZYNYZ (retifanlimab-dlwr) at Low or No Cost This guide explains the **IncyteCARES for ZYNYZ Patient Assistance Program (PAP)**, offered by Incyte Corporation to help eligible patients access **ZYNYZ (retifanlimab-dlwr)**, an FDA-approved immunotherapy for certain cancers like Merkel cell carcinoma (MCC) and squamous cell anal cancer (SCAC). The program provides free medication to qualifying patients without insurance or facing high out-of-pocket costs, though it does not cover infusion administration fees[1][6]. ## About ZYNYZ (retifanlimab-dlwr) **ZYNYZ** is an intravenous PD-1 inhibitor used to treat adults with metastatic or recurrent Merkel cell carcinoma (MCC) or squamous cell carcinoma of the anal canal (SCAC) who have progressed on or are intolerant to platinum-based chemotherapy. Administered every 2 weeks by a healthcare professional, it helps the immune system fight cancer cells. Always consult your doctor for personalized advice, as this guide focuses on financial access, not medical details[1][3][7]. ## Who Qualifies for the Program? The program targets patients **without prescription drug insurance** or those struggling with out-of-pocket costs for ZYNYZ. Key eligibility factors include: - U.S. or Puerto Rico residency. - A valid prescription for an FDA-approved indication. - Demonstrated financial need, often based on household income (though exact limits are not publicly specified; program reps assess case-by-case)[1][6]. **Important exclusions**: Patients with federal/state government insurance (e.g., Medicare, Medicaid, TRICARE) are generally ineligible for the PAP free drug. However, separate savings options may exist for commercially insured patients[1][6][8][9]. ## Income Eligibility Breakdown Specific income thresholds (e.g., Federal Poverty Level percentages) are not detailed publicly. Eligibility hinges on providing household income details during enrollment, evaluated for patients uninsured or underinsured with affordability issues. Here's a summary table based on program descriptions: | Household Size | Income Threshold | Notes | |---------------|------------------|-------| | Individual | Not specified | Assessed case-by-case for uninsured or high OOP costs[1][6] | | Couple | Not specified | Program reps collect and review income info[4] | | Family of 3 | Not specified | No purchase obligations; free med if approved[1] | | Family of 4+ | Not specified | Contact program for personalized assessment | If income details aren't on the HCP form, a representative calls to gather them[1][4]. ## Insurance Requirements - **Eligible**: Uninsured or underinsured patients without government coverage who can't afford costs. - **Ineligible**: Medicare (Part B/D, Advantage), Medicaid, TRICARE, or other federal/state programs. Commercially insured patients may qualify for a separate IncyteCARES Savings Program (min $15.01 OOP required; not valid for government-insured)[6][8][9]. The PAP ensures no reimbursement is sought for free product received[4]. ## Step-by-Step Application Process 1. **Get Prescribed**: Obtain a valid ZYNYZ prescription from your doctor for an FDA-approved use[1]. 2. **Enroll via HCP**: Your healthcare provider (HCP) completes the IncyteCARES enrollment form with your info (name, address, DOB, Medicare ID if applicable, income). Fax to 1-855-525-7207[1][4][6]. 3. **Program Contact**: IncyteCARES reps call within **2 business days** to confirm details, assess PAP eligibility, and explain coverage[1][4]. 4. **Phone Support**: Call **1-855-452-5234** (Mon-Fri, 8 AM-8 PM ET) for questions or direct enrollment help[1][2][6]. 5. **Approval**: If eligible, medication ships free; reauthorization needed periodically[1]. No online application; starts with HCP enrollment[1]. ## Timeline and Delivery - **Processing**: HCP hears back in 2 business days; patient welcome call follows[1][4]. - **Delivery**: Free ZYNYZ shipped to your home or doctor's office. Infusion costs not covered—check with your provider[1][6]. - **Ongoing**: Reauthorization required; notify program of changes in insurance/income[1][4]. ## Alternatives if Denied - **Commercially Insured?** Explore IncyteCARES Savings Program for copay help (up to annual max; resets Jan 1)[5][9]. - **Government Insured?** Contact state Medicaid, Medicare Extra Help, or nonprofits like CancerCare/PanCAN for grants[3]. - **Other Resources**: Visit www.incytecares.com, Cancer Support Community, or ClinicalTrials.gov for trials. Patient brochure downloadable at zynyz.com[3]. - **Appeal**: Call 1-855-452-5234 to discuss denial reasons and resubmit[2]. ## Disclaimer This guide is for informational purposes based on available program details as of latest updates (e.g., terms effective Jan 2024). Programs change; eligibility not guaranteed. Consult your doctor and call IncyteCARES (1-855-452-5234) for current info. Incyte may contact for feedback/support. Not medical advice[1][5]. (Word count: 942)

Program information last verified: March 30, 2026