ZYNYZ

Indicated For

squamous cell carcinoma of the anal canal (SCAC), Merkel cell carcinoma (MCC)

About This Medication

# IncyteCARES for ZYNYZ Patient Assistance Program Patient Guide: How to Get ZYNYZ (retifanlimab-dlwr) at Low or No Cost ZYNYZ (retifanlimab-dlwr) is an FDA-approved immunotherapy used to treat certain advanced skin cancers, like Merkel cell carcinoma (MCC) and squamous cell carcinoma of the skin (SCAC), by helping your immune system fight cancer cells. The **IncyteCARES for ZYNYZ Patient Assistance Program** (PAP) provides **free medication** to eligible uninsured or underinsured patients who struggle with out-of-pocket costs, making treatment more accessible without purchase obligations. ## Who Qualifies for the Program? This program targets patients facing financial barriers to ZYNYZ. To qualify, you must: - Be enrolled in IncyteCARES for ZYNYZ (your doctor starts this process). - Live in the **United States or Puerto Rico**. - Have a **valid prescription** for ZYNYZ for an FDA-approved use, such as MCC or SCAC in adults. - Meet one key criterion: Be **uninsured** for ZYNYZ or have trouble affording out-of-pocket costs. **Important note**: No strict income thresholds (like Federal Poverty Level percentages) are publicly listed, making it needs-based rather than rigidly income-capped. Program reps assess eligibility during enrollment, focusing on financial hardship.[1][3] ## About ZYNYZ (retifanlimab-dlwr) **ZYNYZ** is an intravenous PD-1 inhibitor immunotherapy administered every 2 or 4 weeks in a clinic. It's approved for: - Adult patients with metastatic or recurrent locally advanced MCC after chemotherapy. - Adult patients with locally advanced or metastatic SCAC not cured by surgery or radiation, after platinum chemotherapy or anti-PD-1/PD-L1 therapy. Common side effects include fatigue, muscle/joint pain, rash, diarrhea, and infusion reactions. Serious risks involve immune-related issues affecting organs like lungs or thyroid. Always discuss with your healthcare provider (HCP). The PAP covers the **medication cost only**—not infusion administration fees, which insurance or other aid might help with.[1][2] ## Income Eligibility Breakdown Unlike many programs with fixed Federal Poverty Level (FPL) limits, IncyteCARES PAP uses a flexible, case-by-case review for those 'with trouble affording out-of-pocket costs.' No specific household size thresholds are detailed. | Household Type | Income Threshold | Notes | |---------------|------------------|-------| | Individual | Not specified | Assessed based on financial need; no FPL % listed | | Couple | Not specified | Program reps collect income info if not on form | | Family of 3 | Not specified | Focus on uninsured/underinsured hardship | | Family of 4+ | Not specified | US/Puerto Rico residents only | Contact the program for personalized assessment—no upfront income proof is mandatory on the form, but they may request it.[1][3] ## Insurance Requirements - **Primary focus**: Uninsured patients or those underinsured for ZYNYZ (e.g., high copays). - **Separate Savings Program**: For **commercial insurance** only (not government plans like Medicare Part B, Medicaid, TRICARE). Reduces costs to ~$15 per fill, with limits. - **Government insurance**: Ineligible for PAP or Savings; explore independent foundations. - Even with Medicare Part B or other coverage, if denied ZYNYZ coverage or costs are unaffordable, you may qualify after review.[1][3][4] ## Step-by-Step Application Process 1. **Talk to Your Doctor**: Ask your oncologist or HCP to enroll you in IncyteCARES for ZYNYZ. They complete the **enrollment form** (download at hcp.incytecares.com/oncology-hematology-zynyz/pdf/enrollment-form.pdf). 2. **Provide Required Documents**: - Valid ZYNYZ prescription for FDA-approved use. - Proof of US/Puerto Rico residency (e.g., ID, utility bill). - Signed enrollment form by your HCP. 3. **Submit**: HCP faxes to 855-525-7207 or calls (855) 452-5234 (M-F, 8am-8pm ET). Takes ~15 minutes. 4. **Follow-Up**: IncyteCARES rep calls you to confirm eligibility, explain coverage, and gather any extra info (e.g., income). 5. **Approval**: If eligible, medication ships free.[1][3] **Phone Support**: (855) 452-5234 for questions. ## Timeline and Delivery - **Processing**: Not specified; reps contact promptly after enrollment. - **Delivery**: Shipped free to your home or HCP's office. - Expect an introductory call soon after submission. Refills follow prescription schedule—no reauthorization details listed, but ongoing eligibility applies.[1] ## Alternatives if Denied - **IncyteCARES Savings Program**: If commercially insured (as low as $15).[1] - **Independent Foundations**: IncyteCARES provides referrals for copay help, travel, lodging, or counseling (e.g., CancerCare, Patient Access Network).[1][2] - **Other Resources**: Oncology social workers, support groups via CancerCare or Skin Cancer Foundation.[2] - **Clinical Trials**: Check clinicaltrials.gov for ZYNYZ studies. ## Disclaimer This guide summarizes publicly available info as of program details. **Eligibility, terms, and availability can change**—always verify with IncyteCARES at (855) 452-5234 or your HCP. PAP doesn't guarantee approval; it's not health insurance. Does **not cover infusion costs**. Consult your doctor before starting ZYNYZ. Incyte Corporation reserves rights to modify/amend/terminate. Not for government-insured patients.

Program information last verified: March 25, 2026