Zynlonta

Indicated For

relapsed or refractory diffuse large B-cell lymphoma

About This Medication

# ADVANCING Patient Support Patient Assistance Program Patient Guide: How to Get Zynlonta at Low or No Cost Zynlonta (loncastuximab tesirine-lpyl) is a prescription medication used to treat adults with relapsed or refractory large B-cell lymphoma (LBCL) after at least two prior systemic therapies. The **ADVANCING Patient Support Patient Assistance Program** from **ADC Therapeutics** helps **uninsured or underinsured** U.S. residents, including Puerto Rico, access Zynlonta **for free** if they meet income guidelines and other criteria.[1][2] ## About Zynlonta **Zynlonta** is an antibody-drug conjugate (ADC) approved by the FDA for treating certain types of non-Hodgkin lymphoma, specifically relapsed or refractory diffuse large B-cell lymphoma (DLBCL) not otherwise specified, high-grade B-cell lymphoma, or primary mediastinal large B-cell lymphoma. It works by targeting CD19 on cancer cells and delivering a toxin to kill them. It's given as an intravenous infusion every 3 weeks in cycles, typically in a healthcare setting under medical supervision. Common side effects include low blood cell counts, fatigue, edema, and rash—discuss risks with your doctor.[3][5] This guide focuses on the free drug Patient Assistance Program (PAP) within ADVANCING Patient Support, separate from copay programs for commercially insured patients.[1][7] ## Who Qualifies? To qualify for free Zynlonta through this program: - Be a **U.S. resident** (including Puerto Rico). - Be **uninsured or underinsured** (limited or no prescription coverage). - Meet **program income guidelines** (exact thresholds not publicly disclosed; financial documentation required to verify).[1][2] - Have a valid prescription from a licensed U.S. healthcare provider (HCP). The program is **needs-based** and enrollment is required. It's not for patients with government insurance like Medicare, Medicaid, or VA benefits if they cover prescriptions—those may have separate copay options.[2][3] ## Income Eligibility Breakdown Specific income limits are **not published** publicly, unlike many programs tied to Federal Poverty Level (FPL). You must submit financial documents for case-by-case review. Here's a general overview: | Household Size | Estimated Threshold | Notes | |---------------|---------------------|-------| | Individual | Not published | Based on program guidelines; proof like tax returns needed. | | Couple (2) | Not published | Household income considered. | | Family of 3 | Not published | Includes dependents. | | Family of 4+ | Not published | Contact program for details. | **Tip**: Call (855) 690-0340 to discuss your situation before applying—case managers can provide guidance without full disclosure of limits.[1][2] ## Insurance Requirements - **Uninsured**: No prescription drug coverage at all. - **Underinsured**: Coverage exists but doesn't adequately cover Zynlonta (e.g., high copays, denials, or gaps). Patients on **federal/state programs** (Medicare Part D, Medicaid, Medicare Advantage, VA, DOD, TRICARE) are generally **ineligible** for this free drug PAP but may qualify for other ADVANCING support like copay cards (up to $25,000/year for commercial plans). Full cash-pay patients are excluded from copay aid but may qualify here if income-eligible.[3][4][5] ## Step-by-Step Application Process 1. **Talk to Your Doctor**: Your oncologist or HCP must prescribe Zynlonta and initiate enrollment—they handle most paperwork.[1] 2. **Contact ADVANCING Patient Support**: Call **(855) 690-0340** (Mon-Fri, 8AM-8PM ET) for a dedicated case manager. They'll guide you and start benefits investigation.[1][3] 3. **Complete Enrollment**: HCP submits via: - **Online**: At advancingpatientsupport.com (patient also signs authorization and consent forms).[1] - **Fax**: (855) 915-3005. - **Email**: support@ADVANCINGPatientSupport.com.[1][2] 4. **Gather Required Documents**: - **Financial proof** (e.g., tax returns, pay stubs, bank statements). - **Physician info**: DEA number, NPI, signature. - Patient authorization form.[1][2][7] 5. **Submit and Wait**: HCP faxes/emails the form. Program reviews eligibility.[2] Applications are **multiple methods**—flexible for providers.[1] ## Timeline and Delivery - **Processing time**: Not published; typically weeks—call for status updates.[2] - Approved Zynlonta is **shipped free to your provider's office/clinic**, not home.[1][2] - Quantity varies by prescription; refills/reauthorization details not specified—your HCP handles ongoing needs.[2] Expect a case manager for support throughout treatment, including nursing help.[3] ## Alternatives if Denied - **Appeal**: Ask your case manager for reasons and resubmit updated docs.[1] - **Other ADC Therapeutics Programs**: Copay assistance for commercial insurance ($0/dose possible, max $25,000/year).[5] - **General Resources**: NeedyMeds, RxAssist.org, or PAN Foundation for lymphoma aid. - **Manufacturer Expanded Access**: For eligible 3L+ DLBCL patients.[9] - **No biosimilars** available for Zynlonta.[1] ## Important Disclaimer This guide is for informational purposes only and based on publicly available data as of March 2026. Program details can change—**always verify with ADVANCING Patient Support at (855) 690-0340 or your HCP**. Not medical advice; consult professionals for treatment decisions. ADC Therapeutics or affiliates not liable for use of this info. Eligibility not guaranteed.[1][2]

Program information last verified: March 9, 2026