ZYNLONTA

Indicated For

relapsed or refractory large B-cell lymphoma, DLBCL

About This Medication

# ADVANCING Patient Support Patient Assistance Program Guide: How to Get ZYNLONTA (loncastuximab tesirine-lpyl) at Low or No Cost This patient-friendly guide explains the **ADVANCING Patient Support Patient Assistance Program** from **ADC Therapeutics**, the manufacturer of **ZYNLONTA (loncastuximab tesirine-lpyl)**. It helps uninsured or underinsured patients access this important treatment for relapsed or refractory large B-cell lymphoma without high costs. Whether you're newly diagnosed or seeking ongoing support, this program can cover your medication costs if you qualify.[1][2][6] ## About ZYNLONTA and Why Assistance Matters **ZYNLONTA (loncastuximab tesirine-lpyl)** is an FDA-approved antibody-drug conjugate used to treat adults with relapsed or refractory large B-cell lymphoma after two or more lines of systemic therapy. It works by targeting cancer cells with a toxin, helping to shrink tumors and extend remission. Treatment typically involves cycles every 3 weeks, administered by infusion in a doctor's office.[1][9] Cancer treatment can be expensive, especially infusion drugs like ZYNLONTA. Without insurance coverage, costs can reach tens of thousands per dose. The ADVANCING Patient Support program steps in for eligible patients, providing free medication shipped to your home or doctor's office. This reduces financial stress so you can focus on recovery.[1][2][6] ## Who Qualifies for the Program? The program targets **uninsured or underinsured patients** who meet specific criteria. Key requirements include: - Confirmed diagnosis of a condition treatable with ZYNLONTA (e.g., relapsed/refractory large B-cell lymphoma with ICD-10 code). - U.S. residency. - Ability to provide proof of income and insurance status. - **Exclusion from federal/state programs**: You cannot be enrolled in Medicaid, Medicare (including Part D or Advantage), VA, DOD, or TRICARE if they cover prescriptions.[1][2][5] **Income Eligibility Breakdown** Specific income thresholds (e.g., Federal Poverty Level percentages) are not publicly detailed; eligibility is assessed case-by-case based on household income, size, and financial hardship. Contact the program for a personalized review. Here's a general overview: | Household Size | Estimated Threshold | Notes | |---------------|---------------------|-------| | Individual | Case-by-case | Proof of income required; no fixed FPL % listed. | | Couple | Case-by-case | Assessed for underinsured status. | | Family of 3 | Case-by-case | Excludes government program participants. | | Family of 4+ | Case-by-case | Full financial review. | *Table based on program notes; call 1-855-690-0340 for exact qualification.*[1][5] ## Insurance Requirements - **Uninsured**: No prescription drug coverage at all. - **Underinsured**: Limited commercial coverage that doesn't fully cover ZYNLONTA. - **Strict exclusions**: No eligibility if on any government program with drug benefits (Medicaid, Medicare Parts B/D/Advantage, VA, DOD, TRICARE). Commercially insured patients may qualify for a separate copay program ($0/dose up to $25,000/year max), but Patient Assistance is for those without adequate coverage.[1][2][6] Your case manager will investigate benefits upon enrollment to confirm fit.[2][9] ## Step-by-Step Application Process Applying is straightforward with multiple options. Start with your doctor. 1. **Discuss with your doctor**: Ask them to initiate enrollment during your visit. They'll confirm your diagnosis and prescribe ZYNLONTA.[1][6][9] 2. **Gather documents**: - Patient enrollment form (download from advancingpatientsupport.com or get from doctor).[3][5] - Valid prescription for ZYNLONTA. - Diagnosis documentation with ICD-10 code. - Proof of income (e.g., tax returns, pay stubs) and insurance status (e.g., denial letter or insurance card showing no coverage).[1][3] 3. **Submit application** (multiple methods): - **Online**: Visit https://www.advancingpatientsupport.com and complete digitally.[1][9] - **Phone**: Call 1-855-690-0340 (Mon-Fri, 8 AM-8 PM ET) for help.[1][3] - **Fax**: Send to 1-855-915-3005 after doctor completes.[9] - Doctor can enroll you directly.[1][6] 4. **Welcome call**: Save 1-855-690-0340 in contacts. A dedicated case manager will call to guide you, investigate benefits, and assess eligibility.[1][6][9] 5. **Approval notification**: Doctor's office gets a fax with status.[2] ## Timeline and Delivery Processing time varies but aims for quick turnaround—often days to weeks after complete submission. Your case manager keeps you updated. Once approved, ZYNLONTA ships free to your home or physician's office for infusion. Reauthorization is required periodically; your doctor submits updates.[1][2][9] ## Alternatives if Denied or No Biosimilars No biosimilar alternatives exist for ZYNLONTA.[Provided data] If denied: - Appeal with additional documents via case manager.[9] - Explore copay program if commercially insured ($0/dose, max $25,000/year).[1][2] - Contact support organizations listed on advancingpatientsupport.com.[1] - Other resources: RxAssist.org or general cancer funds like CancerCare.[5][7] ## Reauthorization and Ongoing Support **Reauthorization is required**. Your doctor resubmits proof of continued need, diagnosis, and income/insurance status. Case managers provide nursing support, prior auth help, and appeals guidance throughout treatment.[1][2][9] ## Disclaimer This guide is for informational purposes based on publicly available program details as of latest updates. Eligibility, terms, and availability can change. Always verify with ADVANCING Patient Support at 1-855-690-0340 or https://www.advancingpatientsupport.com. Not affiliated with ADC Therapeutics. Consult your doctor for medical advice. Program excludes purchase requirements; all support is complimentary.[1][2][3][4]

Program information last verified: March 30, 2026