ZYNLONTA

Indicated For

relapsed or refractory large B-cell lymphoma, DLBCL

About This Medication

# ADVANCING Patient Support Patient Assistance Program Patient Guide: How to Get ZYNLONTA (loncastuximab tesirine-lpyl) at Low or No Cost ZYNLONTA (loncastuximab tesirine-lpyl) is a prescription medication used to treat certain types of relapsed or refractory B-cell lymphomas, such as diffuse large B-cell lymphoma (DLBCL), after at least two prior systemic therapies. The **ADVANCING Patient Support Patient Assistance Program** from **ADC Therapeutics** helps **uninsured or underinsured patients** get ZYNLONTA for **free** if they meet income and other eligibility criteria.[1][3][4] ## Who Qualifies for the Program? This program targets patients facing financial hardship due to lack of insurance coverage for ZYNLONTA. Key eligibility includes: - **Uninsured or underinsured** status, meaning no prescription drug coverage or high out-of-pocket costs.[1][3][4] - **U.S. residency** (including Puerto Rico); citizenship or legal residency typically required.[3][4] - Meeting **needs-based income guidelines**, which are not publicly disclosed but assessed case-by-case.[3] - **Not enrolled in federal or state programs** like Medicaid, Medicare Part D, Medicare Advantage, VA, DOD, or TRICARE for copay programs (though PAP is for uninsured/underinsured).[1][2] **Important**: Separate copay assistance exists for commercially insured patients (18+, up to $25,000/year), but this guide focuses on the Patient Assistance Program (PAP) for free drug.[1][2] ## About ZYNLONTA **ZYNLONTA** is an antibody-drug conjugate (ADC) approved for adults with relapsed or refractory large B-cell lymphoma after two or more lines of systemic therapy. It works by targeting CD19 on cancer cells, delivering a toxin to kill them. Administered intravenously by a healthcare provider every 3 weeks (two cycles: 0.15 mg/kg days 1-2, then 0.075 mg/kg days 1-2). Common side effects include low blood cell counts, fatigue, edema, and rash. Always discuss risks/benefits with your doctor.[5][6] The **ADVANCING Patient Support** program provides more than just free medicine: dedicated case managers offer personalized help, insurance navigation, nursing support, and treatment journey guidance.[1][2][7] ## Income Eligibility Breakdown Specific income thresholds (e.g., % of Federal Poverty Level) are **not published** publicly. Eligibility is **needs-based**, evaluated individually based on financial documentation. No deductions for medical expenses or Social Security details are specified.[3] | Household Size | Income Threshold | Notes | |---------------|------------------|-------| | Individual | Not Published | Case-by-case review[3] | | Couple | Not Published | Needs-based assessment[3] | | Family of 3 | Not Published | Financial docs required[3] | | Family of 4+ | Not Published | U.S. residency required[3][4] | Call **(855) 690-0340** for a preliminary eligibility check. Program staff will guide you without full application.[1][4] ## Insurance Requirements - **Primary focus**: **Uninsured** (no coverage) or **underinsured** (coverage exists but unaffordable copays/denials).[1][3][4] - **Exclusions**: Patients in government programs (Medicare, Medicaid, etc.) may not qualify for PAP; check copay program instead if commercially insured.[1][2] - Benefits investigation starts upon enrollment to confirm coverage gaps.[6] ## Step-by-Step Application Process Applications can be submitted **multiple ways** for flexibility. Work with your healthcare provider (HCP).[3][4][5] 1. **Contact Program**: Call **(855) 690-0340** (Mon-Fri, 8AM-8PM ET) to speak with a case manager. They'll assign a dedicated manager and start benefits check.[1][2][4][7] 2. **Gather Documents**: - **Financial documentation** (e.g., tax returns, pay stubs, bank statements).[3][4] - **Patient Authorization form** (patient consent for info sharing).[4][5] - **Patient Assistance Program Consent form**.[4] - **Physician info**: License, DEA, NPI.[3][5] 3. **Complete Enrollment**: - **Online**: Patient/HCP submits forms via advancingpatientsupport.com.[4] - **Fax**: To **(855) 915-3005**.[3][4] - **Email**: support@ADVANCINGPatientSupport.com.[4] - Download forms from zynlontahcp.com or rxassist.org.[3][5] 4. **HCP Signs**: Prescriber must sign; no electronic signature noted.[3] 5. **Submit**: HCP typically handles; patient authorizes release of info.[5] ## Timeline and Delivery - **Processing time**: Not published; case manager provides updates.[3] - **Delivery**: ZYNLONTA shipped **free to your provider's office** (not home).[3] - **Quantity**: Varies by prescription; refills per HCP orders (policy not published).[3] - Expect case manager contact within days of submission for status.[1][7] ## Alternatives if Denied - **Appeal**: Ask case manager for reasons and resubmit docs.[1] - **Copay Program**: If commercially insured (not government), up to $25,000/year savings.[1][2] - **Other PAPs**: Check rxassist.org for ADC Therapeutics or general lymphoma support.[3][10] - **State programs**, nonprofits (e.g., Patient Access Network), or hospital charity care. - **Clinical trials** or expanded access via ADC Therapeutics.[8] - No biosimilars available.[program details] ## Disclaimer This guide is for informational purposes only and based on publicly available data as of 2026. Program details can change; always verify with **(855) 690-0340** or advancingpatientsupport.com. Not medical advice—consult your doctor. ADC Therapeutics/ADVANCING Patient Support not liable for application outcomes. Eligibility not guaranteed.[1][3] *(Word count: 982)*

Program information last verified: March 9, 2026