Zymfentra

Indicated For

Crohn's disease, Ulcerative Colitis

About This Medication

# Celltrion CONNECT Patient Assistance Program Patient Guide: How to Get Zymfentra (infliximab-dyyb) at Low or No Cost Zymfentra (infliximab-dyyb) is a subcutaneous biosimilar to Remicade, used to treat conditions like Crohn's disease, ulcerative colitis, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and plaque psoriasis in adults. The **Celltrion CONNECT Patient Assistance Program (PAP)** offers this medication at no cost to eligible uninsured or functionally uninsured patients facing financial hardship.[1][2] ## About Zymfentra **Zymfentra** is an injectable biologic medication administered under the skin, typically every 2 to 6 weeks after initial doses, allowing home administration after training. As a biosimilar to infliximab (Remicade), it matches in efficacy, safety, and quality but may offer cost savings. It's FDA-approved for maintenance therapy in approved inflammatory conditions. Always consult your healthcare provider (HCP) for personalized advice.[1][10] ## Who Qualifies for the Program? The program targets patients in financial need who lack coverage for Zymfentra. Key criteria include: - Valid prescription for an on-label use from a licensed HCP. - **Uninsured** or **functionally uninsured** (insurance denies coverage for Zymfentra and its reference/generic/biosimilars like Remicade, Inflectra, or unbranded infliximab).[1][2] - No enrollment in government insurance (e.g., Medicare, Medicaid, TRICARE, Medicare Advantage).[1][5] - U.S. resident (including Puerto Rico).[5] - Financial hardship, verified via electronic income verification (eIV); proof required if mismatch (e.g., W-2s, tax returns, pay stubs).[3] **Income Eligibility**: While specific Zymfentra thresholds aren't detailed, Celltrion PAPs typically limit to **<400% Federal Poverty Level (FPL)** based on household size, with no asset test. Contact the program for your situation, as it's not strictly defined in Zymfentra materials.[3] | Household Size | 100% FPL (2026 est.) | 400% FPL Threshold | |----------------|----------------------|---------------------| | 1 (Individual) | ~$15,060 | ~$60,240 | | 2 (Couple) | ~$20,440 | ~$81,760 | | 3 | ~$25,820 | ~$103,280 | | 4 | ~$31,200 | ~$124,800 | *Add ~$5,380 per additional person for 100% FPL. Verify current FPL at HHS.gov; program uses adjusted annual household income.[3] ## Insurance Requirements You qualify if: - Completely **uninsured**.[1][2] - Insured but **plan excludes Zymfentra** and equivalents (you're responsible for 100% cost—functionally uninsured).[1][2] **Exclusions**: - Government programs: Medicare (Parts A/B/D/Advantage), Medicaid, TRICARE, CHAMPUS, Puerto Rico GHP, or similar.[1][5] - Cannot use program value toward FSA/HSA or seek reimbursement from any plan/foundation.[3] Program conducts **electronic benefits verification (eBV)** every 6 months; report changes promptly.[1][3] ## Step-by-Step Application Process 1. **Get a Prescription**: Ensure your HCP prescribes Zymfentra for an approved use. 2. **Gather Documents**: - Proof of income (if eIV fails: W-2s, 1040/1099, 3 months pay stubs).[3] - Proof of residency (e.g., utility bill).[Provided data] - Proof of insurance status/denial (insurance card copies or denial letter).[1][5] 3. **Download & Complete Form**: Get the application at [Celltrion CONNECT](https://www.celltrionconnect.com/static-assets/uploads/US-ZYM-24-00045_ZYM_PAP-App__DIGI_L04.pdf). Fill patient info, income, insurance details; HCP signs.[1] 4. **Submit**: - **Phone**: Call (877) 812-6662 (Mon-Fri 8AM-8PM ET) for help.[1] - **Fax**: 833-912-3707 or as listed.[1] - Multiple methods available.[Provided data] 5. **Verification**: Program reviews via eBV/eIV; may request more docs.[1][3] 6. **Approval**: Rolling 12-month enrollment from approval date.[1] **Tip**: Your HCP or Case Coordinator can assist with enrollment, benefits investigation, prior auth, or appeals.[6][10] ## Timeline and Delivery - **Processing Time**: Not specified; call for updates. eBV/eIV speeds verification.[1][3] - **Delivery**: Shipped free to your home or HCP's office.[Provided data] - **Refills**: Reauthorization required annually or on changes; every 6 months eBV checks coverage.[1][3] - Report insurance/financial changes within 30 days.[2] ## Alternatives if Denied - **Biosimilar Options**: Ask about **Inflectra (infliximab-dyyb, Pfizer)** or **Unbranded Infliximab (Janssen)**; program may cover if eligible.[Provided data] - **Other Assistance**: Celltrion CONNECT offers co-pay support for commercially insured (not govt), prior auth help, appeals.[5][10] - **Foundations**: Independent charities (e.g., PAN Foundation) after denial. - **Discuss with HCP**: Switch meds or appeal denial.[1] ## Important Disclaimer This guide summarizes publicly available info as of 2026; **program terms can change**. Contact Celltrion CONNECT at (877) 812-6662 or www.CelltrionConnect.com for latest details. Not medical/financial advice—consult your HCP/ advisor. Eligibility not guaranteed; fraudulent info disqualifies. Program prohibits resale/abuse of meds.[1][3] (Word count: 942)

Program information last verified: March 30, 2026