Zurampic

Indicated For

gout, hyperuricemia

About This Medication

# Zurampic (lesinurad) Patient Guide: How to Get Zurampic at Low or No Cost **Important Notice: Zurampic has been discontinued.** Ironwood Pharmaceuticals stopped sales of Zurampic (lesinurad) and related products like Duzallo in February 2019. Patient assistance programs are no longer available, and the medication is not currently distributed in the US.[7] This guide provides historical context and alternatives for managing gout-related hyperuricemia. Always consult your doctor for current treatment options. ## About Zurampic (lesinurad) Zurampic was a prescription medication used to treat **hyperuricemia associated with gout** in adults who did not achieve target serum uric acid (sUA) levels with a xanthine oxidase inhibitor (XOI) like allopurinol or febuxostat alone.[2][5] It worked by selectively inhibiting URAT1 and OAT4 transporter proteins in the kidneys, increasing uric acid excretion while XOIs reduce production, providing a dual mechanism to lower sUA levels.[2][4] **Key limitations:** Zurampic was never approved for asymptomatic hyperuricemia or as monotherapy—it had to be combined with an XOI. Clinical trials (CLEAR 1 and 2) showed it nearly doubled the number of patients reaching sUA <6 mg/dL when added to allopurinol.[4] Common side effects included headache, influenza, increased blood creatinine, and gastroesophageal reflux. Serious risks like acute renal failure were more common without an XOI.[2][4][5][8] Gout affects millions, with up to 2 million US patients on urate-lowering therapy still having uncontrolled sUA, leading to flares and joint damage.[2] The American College of Rheumatology recommended uricosurics like Zurampic for such cases.[4] ## Who Qualifies for Assistance? Historically, the **Zurampic Savings Program** (also called ZURAMPIC CoPay Program) by Ironwood Pharmaceuticals helped eligible patients pay no more than **$15 per prescription**.[6] Qualification typically required: - A valid prescription for Zurampic. - US residency. - Private commercial insurance (not government programs like Medicare/Medicaid). - No specific income thresholds were publicly detailed, suggesting it was primarily a copay card for commercially insured patients rather than a full free-drug program for the uninsured.[6] Since discontinuation, no program exists. Third-party services like Prescription Hope offered Zurampic for $70/month pre-2019, but this is obsolete.[3] ## Income Eligibility Breakdown No federal poverty level (FPL) or household size thresholds were specified for Zurampic programs, as they focused on copay reduction for insured patients.[6] For reference, typical pharma programs use 400-500% FPL, but Zurampic did not. Here's a general table of FPL for 2026 (hypothetical, as program is defunct): | Household Size | 100% FPL | 400% FPL | 500% FPL | |---------------|----------|----------|----------| | 1 (Individual)| $15,060 | $60,240 | $75,300 | | 2 (Couple) | $20,440 | $81,760 | $102,200| | 3 | $25,820 | $103,280| $129,100| | 4 | $31,200 | $124,800| $156,000| *Notes: FPL adjusts annually. Zurampic had no FPL limits listed; eligibility hinged on insurance type.[6]* ## Insurance Requirements The savings card was for **commercially insured patients only**—government insurance (Medicare, Medicaid, VA, etc.) disqualified you.[6] It covered copays up to a cap (details not specified post-discontinuation). Uninsured patients had no direct manufacturer PAP; third-party options like Prescription Hope were alternatives pre-2019.[3] ## Step-by-Step Application Process (Historical) 1. **Get Prescribed:** Obtain a prescription from your doctor for Zurampic + XOI. 2. **Check Eligibility:** Visit zurampichcp.com/zurampic-savings-card (inactive now) or call Ironwood patient support.[6][1] 3. **Activate Card:** Register online or by phone for a savings card. 4. **Fill Prescription:** Present card at pharmacy; pay ≤$15 if eligible. 5. **Contact Support:** Ironwood's patient resources page offered general help (ironwoodpharma.com/patients).[1] *Post-discontinuation: No applications possible. Discuss alternatives with your doctor.* ## Timeline and Delivery Copay cards provided **immediate savings at pharmacy**—no shipping, as it reduced out-of-pocket costs directly. Processing was instant upon activation. Refills used the same card until cap reached or eligibility ended.[6] ## Alternatives if Denied or Unavailable - **Switch Medications:** FDA-approved XOIs (allopurinol, febuxostat) or uricosurics like probenecid. Fixed-dose combos like Duzallo were also discontinued.[7] - **Third-Party Assistance:** Services like Prescription Hope, NeedyMeds, or RxAssist for gout drugs (pre-check availability).[3] - **Manufacturer Programs for Other Drugs:** Ironwood focuses on GI; check current gout options via Arthritis Foundation.[6] - **Generic Lesinurad:** None available; drug off-market. - **Lifestyle/Other Therapies:** Diet, hydration, weight management per ACR guidelines.[4] Consult your doctor for generics or new uricosurics. ## Disclaimer This guide is for informational purposes only and based on historical data up to 2019. Zurampic is **no longer available**—do not seek it.[7] It is not medical advice. Eligibility, terms, and availability change; verify with healthcare providers/pharmacies. Programs exclude government insurance. Speak to your doctor before starting/stopping treatments. Ironwood Pharmaceuticals: ironwoodpharma.com/patients.[1] Word count: 942.

Program information last verified: March 30, 2026