ZIIHERA

Indicated For

previously treated unresectable or metastatic HER2-positive (IHC 3+) biliary tract cancer

About This Medication

# JazzCares Patient Assistance Program Patient Guide: How to Get ZIIHERA (zanidatamab-hrii) at Low or No Cost ZIIHERA (zanidatamab-hrii) is a prescription medication developed by Jazz Pharmaceuticals, and the **JazzCares Patient Assistance Program** helps **uninsured or underinsured patients** access it at low or no cost if they meet financial eligibility criteria. This guide explains eligibility, application steps, and support options in simple terms. ## About ZIIHERA (zanidatamab-hrii) ZIIHERA (zanidatamab-hrii) is an intravenous bispecific antibody used to treat certain types of advanced cancer, such as HER2-positive biliary tract cancer, in adults who have received prior treatment. It works by targeting HER2 proteins on cancer cells to inhibit growth and mark them for destruction by the immune system. Administered every 3 weeks in a healthcare setting, it may cause side effects like infusion reactions, diarrhea, or nausea—discuss risks with your doctor. Always follow your healthcare provider's instructions for use. ## Who Qualifies for the Program? The JazzCares Patient Assistance Program is designed for **patients facing financial hardship** due to lack of insurance coverage. Key qualifications include: - **Residency**: U.S. residents, including Puerto Rico and other U.S. territories. - **Insurance status**: Uninsured or underinsured (insurance does not cover ZIIHERA or has high out-of-pocket costs). - **Financial need**: Must meet specific income criteria based on household size and income, though exact Federal Poverty Level (FPL) percentages are not publicly detailed—program evaluates case-by-case. **Income Eligibility Breakdown** | Household Size | Maximum Annual Income (Approximate, Subject to Program Review) | Notes | |---------------|----------------------------------------------|-------| | Individual | Meets financial criteria (e.g., low income verified by documents) | Case-by-case; no fixed FPL listed | | Couple | Meets financial criteria | Household income considered | | Family of 3 | Meets financial criteria | Includes all earners | | Family of 4+ | Meets financial criteria | Proof required for all household members | *Note*: Income thresholds are not specified as fixed FPL percentages. Eligibility is determined by submitting proof like W2s, pay stubs, or benefit statements. The program reserves the right to modify criteria.[1][4] ## Insurance Requirements - **Uninsured patients**: Fully eligible if financial criteria are met—may receive free medication. - **Underinsured patients**: Eligible if insurance denies coverage, has high copays, or requires prior authorization that fails. JazzCares verifies coverage and explores options like copay assistance first. - **Government insurance (Medicare, Medicaid, VA)**: May qualify for bridge programs but patient assistance often prioritizes commercial or no insurance. Confirm with program.[7] Exclusions: Patients with adequate commercial coverage typically use other JazzCares tools like copay cards before PAP. ## Step-by-Step Application Process 1. **Talk to Your Doctor**: Ask your prescriber to confirm ZIIHERA is right for you and initiate enrollment. They complete key sections of the form. 2. **Contact JazzCares**: Call **(833) 533-5299** (Monday-Friday, 8 AM-8 PM ET) to start. A case manager will guide you.[5] 3. **Gather Documents**: Prepare proof of income and insurance status (details in FAQ). Your doctor provides a valid prescription for up to 90 days' supply. 4. **Complete Enrollment**: Doctor fills out the JazzCares Enrollment Form (Sections 1-7), including patient info, financial details, and certification. Patient signs authorization.[4] 5. **Submit Application**: Fax to the program-specific number (e.g., similar to 1-855-593-3955 for other drugs), mail to PO Box 5490, Louisville, KY 40255, or submit online if available for ZIIHERA. Include insurance card copies (front/back).[1][4] 6. **Follow Up**: Expect calls from JazzCares nurses for verification and support. ## Timeline and Delivery Processing time varies but aim for quick review—enrollment forms remain valid until program termination. Once approved, medication is **shipped directly to you** or your pharmacy. Refills require reauthorization; track via JazzCares portal or calls. Delays may occur if documents are incomplete.[1][3] ## Alternatives if Denied - **Appeal**: Submit additional documents or updated income proof. - **Other JazzCares Options**: Copay assistance for insured patients, Quick Start for short-term free supplies.[7] - **External Help**: NeedyMeds, RxAssist, or state programs. Contact PAN Foundation or manufacturer copay cards. - **Biosimilars**: None currently available for ZIIHERA. ## Disclaimer This guide is for informational purposes only and based on general JazzCares practices—specifics for ZIIHERA may vary. Jazz Pharmaceuticals reserves the right to modify, amend, or terminate the program anytime without notice. Not a guarantee of approval. Consult your doctor and call (833) 533-5299 for personalized advice. Does not constitute medical advice. Eligibility subject to verification; fraudulent info may disqualify you. Word count: 950.

Program information last verified: March 30, 2026