Zemaira

Indicated For

Alpha-1 Antitrypsin (AAT) Deficiency, Emphysema

About This Medication

# Patient Assistance Program Patient Guide: How to Get Zemaira (alpha-1 antitrypsin human) at Low or No Cost Zemaira (alpha-1 antitrypsin human) is a vital treatment for adults with alpha-1 proteinase inhibitor (A1-PI) deficiency who have evidence of emphysema. The **Patient Assistance Program** from **CSL Behring LLC** provides free Zemaira to eligible uninsured or underinsured patients, helping ensure access to this life-sustaining therapy without financial burden.[1][2][3] ## About Zemaira and Alpha-1 Antitrypsin Deficiency **Zemaira** is an alpha-1 proteinase inhibitor derived from human plasma, used for chronic augmentation and maintenance therapy. It helps raise alpha-1 antitrypsin (A1-PI) levels in the blood, potentially slowing the progression of emphysema in patients with genetic A1-PI deficiency—a condition where the body doesn't produce enough of this protective protein, leading to lung tissue damage.[3] Alpha-1 lung disease affects about 100,000 Americans, often causing shortness of breath, chronic cough, and emphysema at a young age. Early diagnosis via blood tests (serum A1AT levels and genotype) and lung imaging is crucial. Zemaira is infused weekly or biweekly, typically at home after training. Always consult your doctor to confirm if Zemaira is right for you.[3][5] ## Who Qualifies for the Patient Assistance Program? This program supports **uninsured and underinsured patients** who cannot afford Zemaira. Eligibility is confirmed upon enrollment—no strict income thresholds like Federal Poverty Level (FPL) percentages are publicly listed. Instead, CSL Behring reviews your situation individually during the application process.[2][3] Key qualifiers include: - Diagnosis of A1-PI deficiency with clinical evidence of emphysema. - Lack of ability to pay for medication due to no insurance or insufficient coverage. - **Not enrolled in state- or federally funded insurance** (e.g., Medicare, Medicaid, VA benefits).[3] The program is part of **ZEMAIRA Connect**, a comprehensive support hub offering case managers for personalized guidance on insurance, finances, and therapy start.[2][6] ## Income Eligibility Breakdown Specific income limits (e.g., for individuals, couples, or families) are **not publicly detailed**—eligibility is determined case-by-case upon enrollment. This flexible approach assesses overall financial need.[2] | Household Size | Income Threshold | FPL % | Notes | |---------------|------------------|-------|-------| | Individual | Not specified | N/A | Confirmed at enrollment[2] | | Couple | Not specified | N/A | Support for uninsured/underinsured[1][3] | | Family of 3 | Not specified | N/A | Case-by-case review[2] | | Family of 4 | Not specified | N/A | No fixed FPL limit listed[1] | **Tip:** Even if your income is above typical PAP limits, apply—many factors like medical expenses and assets are considered.[7] ## Insurance Requirements - **Uninsured patients** qualify directly. - **Underinsured patients** (high copays/deductibles) may receive support. - **Exclusions:** State- or federally funded programs like Medicare, Medicaid, or TRICARE disqualify you from this PAP. Private commercial insurance lapses can use the separate CSL Behring Assurance Program.[1][3][9] ZEMAIRA Connect case managers verify coverage and connect you to the right aid, including copay programs for insured patients (ZEMAIRA Signature Savings Co-pay Program).[2][3] ## Step-by-Step Application Process Applying is simple and phone-based—no online form required. 1. **Gather Info:** Have your doctor's diagnosis, A1-PI lab results (serum levels, genotype), recent physical exam, lung imaging, smoking history/cessation proof, allergies, and current meds ready. Your doctor may submit a referral form.[5] 2. **Call to Enroll:** Dial **(866) 936-2472** (1-866-ZEMAIRA), available 8AM-8PM ET, Mon-Fri. Speak to a dedicated **Case Manager** who guides you 1:1.[2][6] 3. **Provide Details:** Share income, insurance status, and household info. Consent to share medical data for eligibility and enrollment in support services.[5] 4. **Doctor Involvement:** Your prescriber may need to complete a referral form, confirming medical necessity and attaching docs like history, labs, and imaging.[5] 5. **Eligibility Review:** Confirmed upon enrollment—often quick, within 24-72 hours for access info.[3] 6. **Approval:** If eligible, receive Zemaira at no cost. Case manager sends a welcome kit and coordinates delivery.[3] **Pro Tip:** Mention ZEMAIRA QuickAccess for up to 4 weeks of free product while processing.[3] ## Timeline and Delivery - **Processing:** Eligibility confirmed at enrollment; access info within ~72 hours of completed referral. Case managers call within 24 hours.[3] - **Delivery:** Free product shipped directly (details via case manager). Up to 4 weeks free initially for eligible patients.[3] - **Ongoing:** Continuous supply while eligible; re-verification may apply. Exact timelines vary—call for your case.[2] ## Alternatives if Denied or Ineligible - **CSL Behring Assurance Program:** Free Zemaira during private insurance lapses (earn points for up to 12 months coverage).[1][9] - **Copay Program:** Covers out-of-pocket for commercial insurance (ZEMAIRA Signature Savings).[1][3] - **Free Trial:** Up to 4 weeks free for new patients via QuickAccess.[3] - **Other Resources:** AlphaNet for peer support; independent foundations like PAN Foundation or RxAssist.org.[3][7] - **State Programs:** Check local aid if federally funded insurance applies. Enroll in ZEMAIRA Connect anyway for navigation help.[2] ## Additional Support - **Nurse Training:** In-home or phone guidance for self-infusion.[1] - **AlphaNet:** Peer counseling from others with alpha-1.[3] - **Stay Connected:** Case managers handle refills, insurance changes.[2] ## Disclaimer This guide is for informational purposes only and based on publicly available data as of program details provided. Eligibility, terms, and availability can change—CSL Behring reserves the right to amend/revoke programs without notice. Always verify directly with (866) 936-2472. Not medical advice; consult your healthcare provider. Program excludes government insurance. Word count: 1028.

Program information last verified: March 30, 2026