XPOVIO

Indicated For

Multiple Myeloma, Diffuse Large B-Cell Lymphoma (DLBCL)

About This Medication

# KaryForward Patient Support Program Patient Guide: How to Get XPOVIO (selinexor) at Low or No Cost XPOVIO (selinexor) is a prescription medication used to treat certain types of cancer, such as relapsed or refractory multiple myeloma and diffuse large B-cell lymphoma (DLBCL), in patients who have received prior treatments. The **KaryForward Patient Support Program**, offered by **Karyopharm Therapeutics Inc.**, helps eligible patients access XPOVIO at low or no cost through options like the Patient Assistance Program (PAP) for uninsured/underinsured patients and a Copay Program for those with commercial insurance. ## About XPOVIO (selinexor) XPOVIO is an oral tablet taken in combination with other medications, such as dexamethasone or rituximab, depending on your cancer type and treatment history. It works by blocking a protein called XPO1, which helps cancer cells grow and survive, thereby slowing cancer progression. Your doctor will determine if XPOVIO is right for you based on your medical history and previous treatments. Common side effects include nausea, fatigue, decreased appetite, and low blood cell counts—discuss these with your healthcare provider. KaryForward provides comprehensive support beyond cost assistance, including nurse case managers for education and emotional support, insurance navigation, and referrals for transportation or other resources. ## Who Qualifies for KaryForward? KaryForward serves **uninsured, underinsured, and commercially insured patients**. Eligibility varies by program: - **Patient Assistance Program (PAP)**: For uninsured or underinsured U.S. residents (including Puerto Rico and U.S. territories) lacking coverage for XPOVIO. Patients may receive XPOVIO at **no cost** if approved. - **Copay Program**: For patients with **commercial (private) insurance** covering XPOVIO. Eligible patients pay as little as **$5 per prescription** (maximum benefits apply; check program terms). - **QuickStart and Bridge Programs**: Free medication during insurance delays or interruptions for patient safety. All patients must be under the care of a U.S.-licensed healthcare professional and reside in the U.S. or its territories. No specific income thresholds are listed, but PAP is needs-based with financial verification. ## Income Eligibility Breakdown KaryForward does not publish fixed income thresholds publicly; eligibility for PAP is determined case-by-case based on financial information provided during enrollment. Here's a general overview: | Program | Insurance Type | Income Consideration | Expected Benefit | |---------|----------------|------------------------|------------------| | **Patient Assistance Program (PAP)** | Uninsured/Underinsured | Needs-based (financial docs verified) | XPOVIO at **no cost** | | **Copay Program** | Commercial/Private | None specified | As low as **$5** per Rx | | **QuickStart/Bridge** | Any (delays) | None | Free supply during gaps | Contact KaryForward at **1-877-527-9493** for personalized eligibility assessment. ## Insurance Requirements - **Uninsured/Underinsured**: Eligible for PAP; provide proof of lack of coverage. - **Commercially Insured**: Eligible for Copay Program if insurance covers XPOVIO. - **Medicare/Medicaid**: Not explicitly eligible for Copay Program (typically commercial only); explore PAP or other assistance. Include insurance cards if applicable. KaryForward offers **insurance verification**, prior authorization help, appeals, and claims support to maximize coverage. ## Step-by-Step Application Process 1. **Discuss with Your Doctor**: Confirm XPOVIO is prescribed and ask them to initiate enrollment. 2. **Sign Patient Consent**: Complete the electronic consent at [KaryForward.com](https://www.karyforward.com) or on the enrollment form. This allows verification of insurance, finances, and eligibility. 3. **Complete Enrollment Form**: Your doctor fills out the **KaryForward Enrollment Form** (online via DocuSign at [KaryForward.com/HCP](https://www.karyforward.com/hcp) or download/fax). Select services like Insurance Verification, PAP, or Copay. 4. **Gather Documents**: - KaryForward Enrollment Form (signed by prescriber in Section 10, patient in Section 11; PAP signature in Section 12 if applying). - Patient Consent. - Insurance verification (both sides of cards if insured). 5. **Submit**: Fax to **1-833-589-1603** or enroll online. Call **1-877-527-9493** (Mon-Fri, 8 AM-8 PM ET) for help, including translation services. 6. **Follow Up**: KaryForward contacts you with status. ## Timeline and Delivery Processing times vary; expect initial review within days, but full approval may take 1-2 weeks depending on verification. Once approved: - Medication ships via specialty pharmacy. - Copay card downloadable for pharmacy use. - Nurse support available ongoing. Refills require prescriber re-enrollment or coordination; reauthorization may be needed periodically. ## Alternatives if Denied - **Appeal Insurance Denial**: KaryForward provides appeals assistance. - **QuickStart/Bridge**: Free supply during delays. - **Third-Party Foundations**: KaryForward can refer to independent funding sources. - **Other Programs**: Check RxAssist.org or PAN Foundation for similar myeloma/DLBCL aid. - **Retrial**: Update financials and reapply. ## Disclaimer This guide is for informational purposes only and based on publicly available program details as of the latest updates. Eligibility, benefits, and terms can change; always verify with KaryForward at 1-877-527-9493 or karyforward.com. Not a substitute for medical or financial advice—consult your doctor and advisor. Karyopharm reserves rights to modify/amend the program.

Program information last verified: March 30, 2026