XOLREMDI

Indicated For

WHIM syndrome

About This Medication

# Patient Assistance Program Patient Guide: How to Get XOLREMDI (mavorixafor) at Low or No Cost XOLREMDI (mavorixafor) is a prescription medication approved for adults and children 12 years and older with WHIM syndrome—a rare immune disorder causing warts, low antibodies, frequent infections, and bone marrow issues—to boost circulating neutrophils and lymphocytes.[1][3][5] The **Patient Assistance Program** from X4 Pharmaceuticals, part of the X4Connect support hub, offers this vital drug **at no cost** to eligible uninsured or underinsured patients, helping bridge gaps in access during treatment.[1][2] ## About XOLREMDI and WHIM Syndrome WHIM syndrome (warts, hypogammaglobulinemia, infections, myelokathexis) is a genetic condition linked to CXCR4 gene issues, trapping white blood cells in the bone marrow and weakening immunity.[3][6] Before XOLREMDI, approved by the FDA in 2024, treatments focused on managing symptoms like antibiotics for infections or wart removal, without targeting the root cause.[8][9] As a **CXC chemokine receptor 4 (CXCR4) antagonist**, XOLREMDI blocks this trapping, raising neutrophil and lymphocyte counts to fight infections better—clinical trials showed up to 60% fewer infections.[1][9] Taken orally once daily, it's a game-changer for patients tired of constant illness. X4Connect provides holistic support: care coordinators handle insurance hurdles, specialty pharmacists guide usage, and financial programs ensure affordability.[2][3] This guide zeroes in on the Patient Assistance Program (PAP), but enrollment unlocks copay help, quick starts, and bridges too.[1] ## Who Qualifies for the Patient Assistance Program? The PAP targets **uninsured or underinsured patients** with a valid XOLREMDI prescription for WHIM syndrome.[1][2] 'Uninsured' means no prescription coverage; 'underinsured' covers high deductibles, denials, or gaps leaving you unable to afford it.[1] You must be 12+ years old with a confirmed WHIM diagnosis, often needing specialist input like from immunologists or hematologists.[3][6] **No strict income thresholds** are published—unlike many programs capping at 400-500% Federal Poverty Level (FPL). Instead, eligibility hinges on financial need proven via household income, expenses, and insurance status. Terms and conditions apply, and X4 may adjust programs.[1] Prescribed by a qualified doctor? Facing coverage barriers? You're a prime candidate.[2] ## Income Eligibility Breakdown Specific income limits aren't detailed publicly, emphasizing case-by-case review for uninsured/underinsured.[1] Here's a general table based on similar programs (consult X4Connect for your situation): | Household Size | Estimated Max Income (400% FPL example)* | Notes | |---------------|-----------------------------------------|-------| | **Individual** | ~$60,000/year | Flexible; proof of need required[1] | | **Couple** | ~$81,000/year | Household income assessed[1] | | **Family of 3** | ~$102,000/year | Includes dependents[1] | | **Family of 4** | ~$123,000/year | Higher for larger families[1] | *Illustrative; actuals vary. Provide tax returns, pay stubs. Medicare/Medicaid often ineligible for PAP but may access other X4Connect options.[4] ## Insurance Requirements **Uninsured or underinsured only**—no commercial coverage, or it's inadequate (e.g., prior auth denied, coverage lapsed).[1][3] Medicare/Medicaid patients typically don't qualify for free PAP drug but can explore copay/bridge aid.[4] X4Connect coordinators verify benefits, appeal denials, and match you to the right program—like Quick Start for delays or Bridge for changes.[1][3] Enroll post-prescription; they'll navigate complexities.[2] ## Step-by-Step Application Process 1. **Get Prescribed**: See a specialist (immunologist, hematologist) confirming WHIM (ANC ≤400 cells/μL often key).[6] Obtain XOLREMDI script. 2. **Enroll in X4Connect**: Visit xolremdi.com/resources/x4connect or call 1-844-XX4-XXXX (Mon-Fri 8am-8pm ET).[1][2] Provide basics: name, contact, prescriber info. 3. **Submit PAP Request**: Select PAP during enrollment. Multiple methods—online form, phone, fax, HCP portal.[2] Include: - Proof of income (taxes, W-2s, pay stubs last 3 months). - Insurance details (denial letter if underinsured). - ID, prescription.[1] 4. **Review & Approval**: Team assesses eligibility. Full terms pre-enrollment.[1] 5. **Receive Meds**: Approved? Shipped free to your home via specialty pharmacy (e.g., PANTHERx).[8] X4Connect handles most paperwork—your coordinator guides you.[3] ## Timeline and Delivery Processing time varies (1-2 weeks typical for PAPs; call for updates).[2] Quick Start offers interim free supply during delays.[1] Meds ship directly to you, with pharmacist counseling on storage/dosing.[2] Refills auto-process if eligible; reauth may apply annually.[1] ## Alternatives if Denied - **Copay Assistance**: Commercial insurance? $0 copay up to annual cap.[1] - **Quick Start/Bridge**: Free temporary supply for delays/changes.[1][3] - **Appeals**: Submit more docs via coordinator.[3] - **Other Aid**: PAN Foundation, NeedyMeds, or state programs. Generic/biosimilar none yet.[1] - **HCP Samples**: Short-term bridge.[6] Discuss with your doctor—don't stop treatment.[9] ## Important Disclaimer This guide summarizes X4Connect PAP based on available info.[1][2] X4 Pharmaceuticals reserves rights to change/discontinue anytime; full terms pre-enrollment. Not medical/financial advice—consult your doctor, X4Connect. Eligibility not guaranteed; individual results vary. See full Prescribing Info for risks.[1][3] Word count: 1028.

Program information last verified: March 30, 2026