XIAFLEX

Endo Advantage Patient Guide: How to Get XIAFLEX at Low or No Cost

About XIAFLEX

XIAFLEX (collagenase clostridium histolyticum) is a prescription medication used to treat Peyronie's disease, a condition characterized by curved or bent penis due to scar tissue buildup. XIAFLEX works by breaking down the collagen in scar tissue, helping to straighten the penis and improve function. Because XIAFLEX carries specific safety risks, it is only available through a restricted program called the XIAFLEX REMS Program, which requires administration by a qualified healthcare provider.

Who Qualifies for Endo Advantage

Endo Advantage is the comprehensive support program offered by Endo Pharmaceuticals to help patients access XIAFLEX affordably. The program includes both a Copay Assistance Program for patients with commercial insurance and financial assistance for uninsured patients.

Income Eligibility

Endo Advantage does not publish specific income thresholds. Instead, eligibility is based on your insurance status:

• Uninsured patients: You may qualify for free or reduced-cost medication
• Commercially insured patients: You may qualify for copay assistance
• Medicare, Medicaid, VA, or federal/state program beneficiaries: You are not eligible for this program

Approximately 94% of eligible patients with commercial insurance should pay $0 out of pocket for XIAFLEX through the Copay Assistance Program.

Insurance Requirements

Other Eligibility Requirements

To qualify for Endo Advantage, you must:

• Be 18 years of age or older
• Be receiving or have received XIAFLEX for an approved indication (Peyronie's disease)
• Have paid or be obligated to pay out-of-pocket costs for XIAFLEX
• Not have used this program within the last 30 days (for each dose)

How to Apply

Step 1: Gather Required Documents

Before contacting Endo Advantage, have the following information ready:

• Proof of insurance or documentation of uninsured status
• Explanation of Benefits (EOB) if you have commercial insurance
• Receipt for cash payments if you are uninsured
• Your prescription from your healthcare provider
• Your contact information and insurance details

Step 2: Contact Endo Advantage

Reach out to Endo Advantage directly:

• Phone: 1-800-743-2382 (voice)
• Fax: 1-800-939-3348

Endo Advantage staff will guide you through the application process and answer any questions about your eligibility.

Step 3: Verification Process

Endo Advantage will:

• Verify your insurance status and eligibility
• Conduct a benefits investigation to determine your out-of-pocket costs
• Contact your doctor to verify that you are receiving XIAFLEX for an approved indication and in the correct manner
• Confirm your eligibility for the program

Step 4: Receive Your Assistance

Once approved, your copay or medication cost assistance will be applied to your prescription. For copay assistance, eligible patients typically pay $0 out of pocket for the XIAFLEX vial itself.

Timeline and Delivery

Endo Advantage does not publish specific processing timelines. However, the program is designed to provide "single point of contact" support to streamline the process. Contact Endo Advantage at 1-800-743-2382 for information about how quickly your application can be processed.

XIAFLEX is dispensed through specialty pharmacies. Endo Advantage can assist with connecting you to the appropriate specialty pharmacy for prescription fulfillment.

Important Limitations

The Endo Advantage Copay Assistance Program covers only the cost of the XIAFLEX vial itself. It does not cover:

• Office visit copays or charges
• Injection or administration fees
• Other out-of-pocket costs associated with your treatment

Each treatment cycle consists of 2 vials of XIAFLEX. You may reapply for assistance for each dose, but you cannot use the program more than once within a 30-day period.

What If Your Application Is Denied

If you are denied assistance through Endo Advantage, contact the program directly at 1-800-743-2382 to understand the reason for denial. Common reasons include:

• Enrollment in Medicare, Medicaid, VA, or federal/state programs
• Having used the program within the last 30 days
• Not meeting age or eligibility requirements

Endo Advantage staff can discuss alternative financial assistance options that may be available to you.

Reauthorization

Because XIAFLEX treatment typically involves multiple injection cycles, you will need to reapply for assistance for each dose. You cannot use the program more than once within a 30-day period. Contact Endo Advantage to reapply when you are ready for your next treatment cycle.

Important Disclaimer

This guide provides general information about the Endo Advantage program based on publicly available information. Program details, eligibility requirements, and benefits may change at any time. For the most current and accurate information, contact Endo Advantage directly at 1-800-743-2382. Always consult with your healthcare provider about whether XIAFLEX is appropriate for your condition and to discuss any potential risks or side effects.