XIAFLEX

Indicated For

Peyronie's disease, Dupuytren's contracture

About This Medication

# XIAFLEX Copay Assistance Program Patient Guide: How to Get XIAFLEX at Low or No Cost XIAFLEX (collagenase clostridium histolyticum) is an injectable medication used to treat Dupuytren's contracture and Peyronie's disease by breaking down abnormal collagen buildup in the hand or penis. The **XIAFLEX Copay Assistance Program**, offered by **Endo Pharmaceuticals**, helps eligible patients reduce out-of-pocket costs for each vial up to **$1,200 per vial**, with about **94% of eligible patients paying $0** after assistance. ## About XIAFLEX **XIAFLEX** is administered by a healthcare professional in a doctor's office. For Dupuytren's contracture, it treats palpable cords causing finger bending. For Peyronie's disease, it reduces penile curvature. Each treatment cycle typically uses 2 vials. Note: XIAFLEX is only available through the **XIAFLEX REMS Program** due to risks like corporal rupture or penile hematoma—discuss with your doctor.[1] ## Who Qualifies? This program targets adults (18+) with a valid XIAFLEX prescription for an approved use. Key requirements: - Uninsured or covered by **commercial insurance** (not government programs). - Residing and treated in the US. - Not used the program in the last 30 days. - Obligated to pay out-of-pocket for XIAFLEX. **Important exclusions**: Medicare, Medicare Part D, Medicare Advantage, Medicaid, VA, or similar federal/state programs. Program not valid where prohibited by law.[3][2] ## Income Eligibility Breakdown This is a **copay assistance program**, not income-based. No specific income thresholds apply—eligibility focuses on insurance type and other criteria above. However, uninsured patients may qualify for free medication through Endo Advantage pathways.[5][8] Here's a simple table of scenarios: | Scenario | Out-of-Pocket Cost for 2 Vials | Program Pays | You Pay | |----------|-------------------------------|--------------|---------| | Low copay | $100 | $100 | **$0** [4]| | Average copay | $1,200 | $1,200 | **$0** [4]| | High copay | $2,650 | $2,400 | **$250** [4]| ~94% pay $0 with commercial insurance (based on 2022-2023 data).[3][7] ## Insurance Requirements - **Eligible**: Commercial/private insurance or uninsured. - **Ineligible**: Medicare (any part), Medicaid, VA, federal/state programs. For insured patients, attach your **Explanation of Benefits (EOB)** showing XIAFLEX costs. Uninsured/cash-pay patients need a payment receipt. Program covers **XIAFLEX vial costs only**—not office visits, injections, or other fees.[2][3] ## Step-by-Step Application Process 1. **Get Prescribed**: Your doctor prescribes XIAFLEX and administers it in-office. Vials come via specialty distributors.[1] 2. **Check Eligibility**: Call **Endo Advantage** at **1-800-743-2382** (voice) or **1-866-585-5591** (copay-specific). They handle benefits checks, prior authorizations, and assistance options.[1][2] 3. **Receive Treatment**: Pay your out-of-pocket at the office. 4. **Submit for Reimbursement**: - Download/print the **Copay Reimbursement Form** from XIAFLEX.com.[2] - Attach EOB (insured) or receipt (uninsured). - Submit via: - Mail: XIAFLEX® Copay Savings Program, PO Box 7017, Bedminster, NJ 07921 - Fax: 1-908-809-6249 - Email: (check form for current)[2] - Sign form authorizing payment to your provider. 5. **Get Reimbursed**: Funds go to your doctor's office, who credits you. Processing takes up to **15 business days**; EOBs may arrive in 1-3 months.[4] Endo may contact your doctor to verify details.[3] ## Timeline and Delivery - **Benefits/PA Support**: Quick via Endo Advantage.[1] - **EOB Wait**: Up to 3 months post-injection.[4] - **Processing**: 15 business days after submission.[4] - **Delivery**: **Medication vials provided at physician office**—never shipped home.[1][4] Call if you miss follow-ups.[4] ## Alternatives if Denied - **Endo Advantage Full Support**: Uninsured? Explore free medication options via 1-800-743-2382.[1][5][8] - **Other Assistance**: RxAssist.org lists Endo programs.[5] - **Appeal**: Resubmit with complete docs or call for review. - **No Biosimilars**: None available.[program details] Contact Endo for custom options.[6] ## Disclaimer This guide is for informational purposes based on available program details as of latest data. Eligibility, terms, and benefits can change—Endo reserves rights to amend/revoke. Not health advice. Consult your doctor/pharmacist. Program covers US-administered doses only; selling/trading offers prohibited. See full terms at XIAFLEX.com or call 1-800-743-2382. (Word count: 942)

Program information last verified: March 30, 2026