Vyleesi

Indicated For

Hypoactive Sexual Desire Disorder (HSDD)

About This Medication

# Vyleesi Copay Program Patient Guide: How to Get Vyleesi at Low or No Cost Vyleesi (bremelanotide) is an FDA-approved injectable treatment for premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD), helping to increase sexual desire when used as needed.[1][5][7] This guide explains the **Vyleesi Copay Program** from manufacturer Cosette, which can make Vyleesi **free or low-cost** for eligible patients with commercial insurance.[1][2] ## About Vyleesi **Vyleesi** is a melanocortin receptor agonist administered via subcutaneous autoinjector, typically 45 minutes before anticipated sexual activity.[1][3][4] Each prescription includes **4 single-use autoinjectors** (one pack), with a wholesale acquisition cost (WAC) around $899 without assistance.[1][3] It activates brain receptors to boost sexual desire and lasts 8-10 hours, differing from oral options like Addyi.[3][4] **Key facts**: - For **premenopausal women** with HSDD lasting at least 6 months, not due to medical issues, relationships, medications, or depression.[7] - **Maximum use**: 1 dose (1.75 mg) per day, no more than 8 doses per month.[8] - **Common side effect**: Nausea (40% of patients), often improving after the first dose; may need anti-nausea medication.[1] - Available **only through specialty pharmacy BlinkRx** in Boise, Idaho.[1] Vyleesi is **not a daily pill**—it's on-demand, self-injected in the thigh or abdomen.[4] ## Who Qualifies for the Vyleesi Copay Program This is a **copay assistance program**, not a full free-drug program for uninsured patients.[1][2] Eligibility focuses on insurance and age: - **Age**: Must be **18 years or older**.[1] - **Insurance**: **Eligible commercial insurance** required; covers copay, coinsurance, or deductible (subject to plan rules).[1][2] - **Exclusions**: **Government insurance** like Medicaid, Medicare, TRICARE, or VA not eligible.[1] - **Usage limits**: Assistance applies to **2 fills every 30 days**; not retroactive.[1] - **No strict income limits** mentioned—evaluated individually.[1] Patients without coverage or cash-pay get **discounted pricing** (e.g., $99-$149 per fill depending on value).[1][3] ## Income Eligibility Breakdown The program has **no federal poverty level (FPL) thresholds** or household income caps listed, as it's insurance-based copay help.[1][2] Eligibility is determined case-by-case. Here's a summary table: | Household Size | Income Threshold | FPL % | Notes | |---------------|------------------|-------|-------| | Individual | None specified | N/A | Commercial insurance primary; individual review [1][2] | | Couple | None specified | N/A | Same as above | | Family of 3 | None specified | N/A | Focus on insurance, not income | | Family of 4 | None specified | N/A | Government insurance ineligible [1] | **Note**: Uninsured or non-covered get cash discounts, not full free medication.[1][3][4] ## Insurance Requirements - **Must have commercial/private insurance** that offers coverage (even if not fully).[1][2] - **Government programs ineligible**: Medicaid, Medicare, TRICARE, etc.[1] - Many plans require **prior authorization** (PA); over 50% of commercial/Medicaid plans need it, but step therapy rare (<1%).[4] - Program helps with **out-of-pocket costs** (copay/coinsurance/deductible), but insurer must cover the drug.[1] - **Medicare patients**: Not eligible.[1] ## Step-by-Step Application Process 1. **Get prescribed**: Your doctor e-prescribes to **BlinkRx (Boise, ID)** via EMR dropdown or faxes prescription + insurance card + BlinkRx form (download from vyleesipro.com).[1] 2. **Enroll in program**: Visit **vyleesipro.com** or use PrescriberPoint for copay card/enrollment forms.[1][2] Patient details auto-evaluated. 3. **Pharmacy handles**: BlinkRx verifies eligibility, processes insurance/PA if needed, applies copay assistance.[1] 4. **Pay at pickup**: **$0** for most eligible; up to $49/$99/$149 tiers based on coverage.[1][3] No separate application phone/URL specified beyond site and pharmacy fax.[1] ## Timeline and Delivery - **Processing**: Not specified; pharmacy handles post-prescription (expect standard 3-7 days + PA if required).[4][7] - **Delivery**: Via **BlinkRx specialty pharmacy**; enhanced auto-refill option available.[1][3] - **Initial approval** (if PA needed): Often 8 weeks; renewals 6-12 months.[7][8] - **Refills**: Up to 2 fills/30 days; program may require reauthorization.[1][8] Shipped directly; track via BlinkRx. ## Alternatives if Denied or Ineligible - **Discounted cash price**: $99-$149/fill or ~$290/injector via pharmacy.[1][3][4] - **GoodRx**: No specific discount listed for Vyleesi.[4] - **Other HSDD treatments**: Addyi (daily oral, but different warnings).[3][7] - **Appeal PA**: Doctor resubmits with criteria (e.g., 6-month HSDD history, no other causes).[7] - **No biosimilars** available.[provided] - Check insurer for coverage exceptions. ## Important Disclaimer This guide is for informational purposes based on available sources as of 2026.[1][2][3][4] Program details can **change or discontinue** anytime due to eligibility, laws, or availability.[1] **Consult your doctor** for medical advice; not a substitute. Cosette not liable for third-party info. Eligibility not guaranteed—verify at vyleesipro.com or with BlinkRx. **Side effects**: Seek help for severe nausea or other issues.[1] Word count: 1028.

Program information last verified: March 30, 2026