Vyjuvek

Indicated For

dystrophic epidermolysis bullosa

About This Medication

# Krystal Connect Patient Assistance Program Guide: How to Get Vyjuvek (beremagene geperpavec-svdt) at Low or No Cost Vyjuvek (beremagene geperpavec-svdt) is a topical gene therapy applied weekly to wounds for patients with dystrophic epidermolysis bullosa (DEB), a rare genetic skin disorder causing fragile, blistering skin.[1][2] Krystal Biotech's **Krystal Connect** program offers personalized support, including the Patient Assistance Program (PAP) that provides Vyjuvek at **no cost** to eligible patients with financial need who are uninsured or functionally uninsured.[1][3] ## About Vyjuvek and DEB DEB leads to painful wounds that heal slowly. Vyjuvek delivers functional **COL7A1** genes directly to wounds using a modified herpes simplex virus, helping produce type VII collagen to strengthen skin attachments.[1] It's applied topically at home or in a clinic, weekly until wounds close, mixed with gel and covered with dressings.[2] Krystal partners with **Option Care Health** for home delivery, training by Clinical Nurse Educators, and supplies like gloves, scissors, hydrophobic dressings, and sharps containers.[2] ## Who Qualifies for Assistance? Krystal Connect helps all Vyjuvek patients but has targeted programs: - **Patient Assistance Program (PAP)**: Free Vyjuvek for uninsured, functionally uninsured (e.g., high deductibles), or those with **qualifying financial need**. Must be **U.S. citizens or residents for at least 6 months**, 18+ (or guardian), with a valid prescription. Assistance up to **12 months**, with annual reapplication; monthly insurance reviews.[3][6][7] - **$0 Copay Program**: For commercially insured, reduces out-of-pocket to **$0** up to **$15,000 annual max** (excludes medical services).[1][3][6] - **Quick Start Program**: Free 12-week supply (7-day increments) while awaiting insurance approval.[2][7] Patients on government programs (e.g., Medicare) may qualify for PAP if functionally uninsured.[7] ## Income Eligibility Breakdown Specific FPL thresholds aren't publicly detailed; eligibility requires **proof of financial need** via documents like recent U.S. tax returns.[7] "Qualifying financial need" is assessed case-by-case by Krystal Connect. | Household Size | Estimated Threshold | Notes | |---------------|-------------------|-------| | Individual | Case-by-case | Tax return required; uninsured or high costs[7] | | Couple | Case-by-case | US resident 6+ months[3][6] | | Family of 3 | Case-by-case | Annual reapplication[7] | | Family of 4+ | Case-by-case | Functionally uninsured OK[7] | Contact Krystal Connect for personalized review: **1-844-5-KRYSTAL (1-844-557-9782)**.[4][8] ## Insurance Requirements - **Commercially insured**: Use Copay Program for $0 costs (up to $15K/year). Krystal Connect aids prior authorizations and benefits investigation.[1][2] - **Uninsured/Functionally uninsured**: PAP provides free drug.[1][3] - **Government insurance (Medicare/Medicaid)**: May qualify for PAP if coverage doesn't include Vyjuvek; not eligible for Copay Program.[6][7] - All: Option Care Health handles authorizations and home delivery.[2] ## Step-by-Step Application Process 1. **Consult your doctor**: Confirm Vyjuvek suitability for your DEB wounds.[1] 2. **Complete Enrollment Form**: Doctor prescribes Vyjuvek (5 x 10^9 PFU/mL vials); fill patient/prescriber sections. Fax/mail to Krystal Connect.[4] 3. **Welcome Call**: Patient Access Liaison (PAL) contacts you to assess needs, insurance, and assistance options.[1] 4. **Benefits Investigation**: PAL verifies coverage, assists prior auth if needed.[1][2] 5. **Submit PAP Documents** (if applying): Tax returns, proof of residency, income verification. For Quick Start, minimal eligibility (U.S. resident, prescription).[7] 6. **Approval & Start**: Free Quick Start if pending insurance; PAP for up to 12 months. Option Care coordinates delivery/training.[2][7] Download forms at vyjuvek.com or call **1-844-557-9782**.[4][8] ## Timeline and Delivery - **Enrollment to Welcome**: Days.[1] - **Benefits/Approval**: Varies; Quick Start provides interim supply in 7-day shipments to doctor's site/home.[7] - **Delivery**: Weekly via Option Care Health to home; includes supplies and nurse training. Ongoing PAL check-ins.[1][2] - **Treatment**: Weekly applications until wounds heal.[1] ## Alternatives if Denied or Ineligible - **Copay Program** if commercially insured.[1] - **Quick Start** for insurance delays.[2] - Independent foundations (e.g., DEBRA) or state programs.[8] - **Biosimilars**: None available.[Provided data] - Appeal denial with updated documents; contact PAL for options.[1] ## Important Disclaimer This guide summarizes publicly available info as of 2026; eligibility/terms change. Not medical/financial advice. Consult your doctor and Krystal Connect (**1-844-557-9782**) for personalized details. Programs exclude cash-pay patients from Copay; max benefits apply. Full terms at krystalconnect.com.[3][6][7] (Word count: 912)

Program information last verified: March 30, 2026