Tyruko

Indicated For

Relapsing forms of multiple sclerosis, Crohn's disease

About This Medication

# Sandoz Patient Assistance (SPA) Patient Guide: How to Get Tyruko (natalizumab-sztn) at Low or No Cost Tyruko (natalizumab-sztn) is a biosimilar medication used to treat relapsing forms of multiple sclerosis (MS) and moderately to severely active Crohn's disease in adults. The **Sandoz Patient Assistance (SPA)** program, also known as Sandoz One Source, provides **Tyruko at no cost** to eligible patients with no or limited insurance coverage who meet specific income requirements.[1][2] ## About Tyruko (natalizumab-sztn) **Tyruko** is an injectable monoclonal antibody that works by preventing immune cells from entering the brain and spinal cord, reducing inflammation and MS relapses. It's administered via intravenous (IV) infusion every 4 weeks by a healthcare professional. As the first FDA-approved biosimilar to Tysabri (natalizumab), Tyruko offers a more affordable option with similar efficacy and safety.[5][7][8] **Important safety note**: Due to the risk of progressive multifocal leukoencephalopathy (PML), a serious brain infection, Tyruko is only available through the **TYRUKO REMS** (Risk Evaluation and Mitigation Strategy) program. Prescribers, infusion sites, and patients must be certified in this program.[5][6][7][8] ## Who Qualifies for Sandoz Patient Assistance (SPA)? The SPA program helps U.S. patients who: - Have been prescribed Tyruko for an FDA-approved use. - Lack adequate drug coverage (uninsured or underinsured). - Meet **income eligibility** based on Federal Poverty Level (FPL) guidelines. - Reside in the United States. Patients with Medicare, Medicaid, or other government insurance may have limited eligibility—check specifics below.[1][2][4] ## Income Eligibility Breakdown SPA typically bases eligibility on household income at or below **400-500% of the FPL**, adjusted for household size. Exact thresholds aren't publicly detailed online but align with standard pharmaceutical assistance programs. Use this table as a general guide (2026 FPL estimates; verify with program for current figures): | Household Size | 400% FPL Monthly Income | 500% FPL Monthly Income | |----------------|--------------------------|--------------------------| | 1 | ~$4,900 | ~$6,125 | | 2 | ~$6,650 | ~$8,310 | | 3 | ~$8,400 | ~$10,500 | | 4 | ~$10,150 | ~$12,690 | | +1 person | +$1,750 | +$2,190 | *Income includes wages, Social Security, etc. Assets may be considered.* Contact Sandoz One Source to confirm your eligibility.[1][2] ## Insurance Requirements - **Uninsured patients**: Fully eligible if income-qualified. - **Underinsured**: Program covers out-of-pocket costs if insurance denies coverage or copays are unaffordable. - **Medicare Part D**: Often ineligible for free drug, but may qualify for copay assistance. - **Medicaid/VA**: Typically ineligible. All patients must exhaust insurance options first. SPA coordinates benefits.[1][2] ## Step-by-Step Application Process 1. **Get Prescribed**: Ask your doctor for Tyruko. They must enroll in the TYRUKO REMS program.[6] 2. **Contact Sandoz One Source**: Call **1-855-4TYRUKO (1-855-489-7856, Option 2)** or visit the patient support site.[2] 3. **Submit Application**: Download forms online or request by phone/fax (**1-855-530-1402**). Include: - Proof of income (tax returns, pay stubs, W-2s). - Proof of residency. - Insurance info (if any). - Prescriber details.[1][2] 4. **Doctor Completes Section**: Your healthcare provider signs off on medical necessity and REMS certification. 5. **Submit**: Fax, mail, or upload electronically. 6. **Approval Notification**: Via phone/mail within days to weeks.[1][2] ## Timeline and Delivery - **Processing**: 5-10 business days typical; urgent cases faster.[1] - **Delivery**: Tyruko ships free to your home, doctor's office, or certified infusion center via REMS restrictions. Infusions occur at REMS-approved sites.[5][6] - **Supply Duration**: 1-3 months per approval; renew as needed. ## Alternatives if Denied or Ineligible - **Appeal**: Resubmit with additional docs or updated income.[1] - **Biosimilar Alternative**: **Tysabri (natalizumab)**—original reference drug; similar programs available.[provided] - **Other MS/Crohn's Assistance**: PAN Foundation, HealthWell Foundation, or state programs. - **Manufacturer Copay Cards**: Check Sandoz One Source for insured patients. - **Generic/Other Options**: Discuss with doctor (e.g., ocrelizumab for MS). ## Refills and Reauthorization Reapply every 6-12 months or as supply ends. Automatic reminders from Sandoz. Continued eligibility requires updated income proof.[1][2] ## Additional Support Sandoz One Source offers: - Nurse educators. - Coverage appeals help. - Injection/infusion training. Call **1-855-4TYRUKO** for personalized guidance.[2][3] ## Disclaimer This guide is for informational purposes only and based on publicly available data as of 2026. Program details can change—**always verify directly with Sandoz One Source at 1-855-489-7856**. Not medical advice. Consult your doctor for treatment decisions. Eligibility not guaranteed. Sandoz Inc. reserves rights to modify program.[1][2][4]

Program information last verified: March 30, 2026