Tryvio

Indicated For

resistant hypertension

About This Medication

# TRYVIO Patient Guide: How to Get Tryvio at Low or No Cost TRYVIO (aprocitentan), made by Idorsia, is a prescription medicine approved by the FDA to treat high blood pressure (hypertension) in adults when other blood pressure medications alone are not enough.[1][4][6] This guide explains how to access TRYVIO through its patient support programs, including a free trial and savings card, dispensed exclusively via Walgreens Specialty Pharmacy.[1][2] ## About TRYVIO TRYVIO is the first endothelin receptor antagonist approved for hypertension in nearly 40 years. It works by blocking endothelin receptors to help lower blood pressure when added to other antihypertensive drugs.[4][6] The recommended dose is 12.5 mg taken once daily by mouth, with or without food.[5][7] **Important safety note:** TRYVIO is only available through the TRYVIO REMS (Risk Evaluation and Mitigation Strategy) program due to the risk of embryo-fetal toxicity. Prescribers must enroll once in the REMS; no patient enrollment is needed. People who can become pregnant must use effective birth control during treatment and for one month after stopping TRYVIO. Do not take if pregnant, trying to become pregnant, or allergic to aprocitentan.[4][5][6] TRYVIO became available in the US in November 2024.[5] It's for adults whose blood pressure remains high despite other treatments. Clinical trials showed it lowers systolic blood pressure effectively within two weeks, with consistent effects on diastolic pressure.[4] ## Who Qualifies for TRYVIO Support Programs Idorsia offers two main support options through TRYVIO Patient Support: - **30-Day Free Trial:** Eligible for your first TRYVIO prescription, regardless of insurance. Covers up to 30 tablets (one-time use). Ask your doctor about this.[1][2][8] - **TRYVIO Savings Program:** Commercially insured patients may pay as little as **$10 per month**. Not valid for Medicare, Medicaid, or other government programs. Must be 18+, US resident.[1][8] Walgreens Specialty Pharmacy handles everything automatically: they check insurance, apply support, and determine your cost.[1][2] No separate patient assistance program with income thresholds is detailed from Idorsia; support focuses on commercial insurance.[1][2][8] If you're uninsured or underinsured, explore third-party options like PAN Foundation or Patient Advocate Foundation (see Alternatives section).[3] ## Income Eligibility Breakdown Idorsia's programs do not list specific income thresholds; eligibility is based on commercial insurance status.[1][8] For reference, third-party copay programs often use Federal Poverty Level (FPL) guidelines. Here's a general 400% FPL table for 2026 (approximate; check HHS.gov for exact figures): | Household Size | Annual Income Limit (400% FPL) | |----------------|-------------------------------| | 1 (Individual) | $60,240 | | 2 (Couple) | $81,760 | | 3 | $103,280 | | 4 | $124,800 | *Add ~$21,520 per additional person. These are examples for copay relief programs like Patient Advocate Foundation (up to 400% FPL).[3] Idorsia programs have no FPL limits listed.[1]* ## Insurance Requirements - **Commercial Insurance:** Best fit for TRYVIO Savings Program ($10/month possible).[1][8] - **Medicare/Medicaid/Government Programs:** Ineligible for Idorsia savings card. Check state Medicaid or manufacturer for expanded access.[3][8] - **Uninsured:** Free trial may apply; otherwise, contact Walgreens or Idorsia.[1][10] Your doctor e-prescribes to Walgreens Specialty Pharmacy, who verifies coverage.[2] ## Step-by-Step Application Process No patient application needed for Idorsia programs—it's streamlined: 1. **Talk to Your Doctor:** Discuss if TRYVIO suits you. Mention the free trial or savings program. Your doctor enrolls in TRYVIO REMS (one-time).[1][5] 2. **Get Prescribed:** Doctor e-prescribes TRYVIO (with refills) to **Walgreens Specialty Pharmacy** via EHR.[1][2] 3. **Pharmacy Contacts You:** Walgreens calls to confirm insurance, shipping address, and applies support (free trial or $10 copay if eligible).[1] 4. **Receive Medication:** Shipped to your home or preferred spot in a few days.[1] For third-party aid (e.g., PAN, HealthWell, Patient Advocate): - Visit their sites, apply online/phone with proof of income, insurance, diagnosis.[3] ## Timeline and Delivery - **Prescription to Contact:** Immediate—Walgreens reaches out soon after doctor sends Rx.[1] - **Processing/Shipping:** Within a few days.[1] - **Delivery:** Free home shipment via Walgreens Specialty Pharmacy.[1] Refills: Doctor includes them in e-prescription; pharmacy manages.[2] ## Alternatives if Denied or Ineligible - **Free Trial:** One-time regardless of insurance.[1] - **Copay Cards:** NowPatient savings card (up to 90% off at 65,000+ pharmacies).[3] - **Foundations:** - Patient Access Network (PAN): For copays if insured, US resident.[3] - Patient Advocate Foundation Co-Pay Relief: Up to 400% FPL, insured, call 866-512-3861.[3] - HealthWell Foundation: Check if TRYVIO covered.[3] - **Medicaid:** Apply via state programs; may cover full cost.[3] - **Manufacturer:** Call Idorsia for other options if prescribed for FDA-approved use.[3][10] ## Disclaimer This guide is for informational purposes only and not medical or financial advice. Eligibility, terms, and availability can change; always verify with Walgreens Specialty Pharmacy, your doctor, or Idorsia. TRYVIO has serious risks (e.g., embryo-fetal toxicity, fluid retention); follow REMS and doctor guidance. Consult healthcare providers for personalized advice. Data current as of program details provided.[1][2][3][4][5][8]

Program information last verified: March 30, 2026