TAKHZYRO

Indicated For

Hereditary Angioedema (HAE)

About This Medication

# Takeda Patient Support Co-Pay Assistance Program Patient Guide: How to Get TAKHZYRO (lanadelumab-flyo) at Low or No Cost TAKHZYRO (lanadelumab-flyo) is a prescription medication used to prevent hereditary angioedema (HAE) attacks in patients 2 years and older. The **Takeda Patient Support Co-Pay Assistance Program** helps eligible, commercially insured patients reduce or eliminate out-of-pocket costs for TAKHZYRO, potentially covering up to 100% of co-pays.[1][2][5] ## About TAKHZYRO and Why Assistance Matters **TAKHZYRO** is a specialty injectable treatment administered subcutaneously every 2 or 4 weeks, depending on your doctor's recommendation. HAE is a rare genetic condition causing sudden, painful swelling episodes that can affect the face, hands, feet, throat, or abdomen. Without treatment, attacks can be debilitating and life-threatening if they block airways. TAKHZYRO works by inhibiting plasma kallikrein, a protein that contributes to bradykinin production—the substance responsible for swelling in HAE. Clinical studies showed it significantly reduced attack rates: patients had about 87% fewer attacks compared to placebo.[5] As a biologic, TAKHZYRO is expensive, often costing thousands per dose without assistance. This program bridges the gap for those facing high co-pays or deductibles.[1][2] ## Who Qualifies for the Program? This is a **co-pay assistance program** designed for **commercially insured patients only**. You must meet these key criteria: - Prescribed TAKHZYRO for an FDA-approved indication (prevention of HAE attacks).[2][7] - Have commercial (private) insurance, including Marketplace plans.[2] - Be a U.S. resident (or U.S. territory for some programs).[3][4] **Important exclusions**: The program cannot be used if you are a beneficiary of **Medicare, Medicare Advantage, Medicaid, TRICARE, state pharmaceutical assistance programs, Medicare Part D, or if your insurance already covers the entire prescription cost**.[1][2][7] Government-insured patients may qualify for Takeda's separate Help at Hand Patient Assistance Program if uninsured or underinsured with low income.[3][8] There are **no income thresholds** for this co-pay program, making it accessible regardless of earnings—as long as you have commercial insurance.[2] ## Income Eligibility Breakdown Since this is a co-pay program without income limits, eligibility hinges on insurance type rather than finances. Here's a clear table: | Insurance Type | Eligible for Co-Pay Program? | Notes / Alternatives | |-----------------------------|------------------------------|----------------------| | **Commercial/Private** | **Yes** | Up to 100% co-pay coverage. Includes employer plans, Marketplace.[2] | | **Medicare/Medicare Adv.** | **No** | Try Help at Hand PAP if income <150% FPL (after Extra Help denial).[8] | | **Medicaid** | **No** | Explore state programs.[3] | | **TRICARE** | **No** | Military-specific options.[2] | | **Uninsured/Underinsured** | **No** (for co-pay) | Help at Hand PAP for free meds if low income.[3] | | **Fully Covered by Ins.** | **No** | Program not needed.[1] | ## Insurance Requirements Your commercial insurance must cover TAKHZYRO, but high co-pays, deductibles, or coinsurance can qualify you for help. Takeda verifies benefits upon enrollment. Note: If enrolled in a co-pay maximizer (where insurer adjusts true out-of-pocket based on assistance), your benefit may vary to maximize value. Takeda may adjust or end support at discretion.[2] Prior authorization (PA) or letter of medical necessity may be needed—support specialists help with this.[7] ## Step-by-Step Application Process Enrollment is straightforward with **multiple methods**:[1][2] 1. **Call Takeda Patient Support**: Dial **(866) 888-0660** (Monday-Friday, extended hours). Specialists guide you, verify insurance, and enroll instantly.[1][2] 2. **Online Enrollment**: Visit **takedapatientsupport.com/HCP** (HCP portal, but patients can start via main site). Fill out the form in minutes; electronic approval follows.[2][5] 3. **Fax a Start Form**: Download from the website, complete with prescriber, and fax. Quick for offices.[2] 4. **Specialty Pharmacy Coordination**: TAKHZYRO ships via **specialty pharmacy** (e.g., Accredo or others partnered with Takeda). They'll handle delivery post-approval.[5] **Required Documents**: Typically none upfront for co-pay card—insurance verification suffices. Prescriber attestation confirms FDA-approved use and commercial coverage.[7] No proof of income needed.[2] Upon approval, receive a **co-pay card** (digital + mail) usable at pharmacy. Activate for refills.[4] ## Timeline and Delivery - **Processing**: Often instant via phone/online; fax may take days. Full verification (insurance/PA) varies but aims for quick start.[2][5] - **Delivery**: Specialty pharmacy ships directly to your home or doctor's office. Nursing support available for injection training.[5] - **Refills**: Card active 12 months; re-enroll annually online or by phone. Program tracks refills automatically.[4] Exact timelines depend on insurance; call for status. ## Alternatives if Denied or Ineligible - **Government Insured/Low Income**: Apply to **Takeda Help at Hand PAP** (1-800-830-9159). Needs proof of income, U.S. residency, prescription. Reviewed in 5-7 days; free meds if approved. Medicare patients below 150% FPL must deny Extra Help first.[3][8] - **Quick Start Program**: For new commercially insured patients; expedited access.[7] - **Other Resources**: PAN Foundation, NeedyMeds, or HAE-specific groups like USHAE. Takeda specialists explore options.[1] ## Disclaimer This guide is for informational purposes based on publicly available program details as of latest updates. Eligibility, benefits, and terms can change; Takeda reserves rights to amend/terminate.[2] Always verify with Takeda at (866) 888-0660 or takedapatientsupport.com. Not tax/financial advice. Consult your doctor/pharmacist. Program not health insurance. Void where prohibited.[1][2][4]

Program information last verified: March 30, 2026