TAKHZYRO

Indicated For

Hereditary Angioedema (HAE)

About This Medication

# Takeda Patient Support Patient Guide: How to Get TAKHZYRO (lanadelumab-flyo) at Low or No Cost TAKHZYRO (lanadelumab-flyo) is a prescription medicine used to prevent hereditary angioedema (HAE) attacks in adults and children 12 years and older. Takeda's Patient Support program offers co-pay assistance for eligible commercially insured patients and free medication through Help at Hand for uninsured or underinsured U.S. residents.[1][2][5][8][10] ## About TAKHZYRO and Hereditary Angioedema (HAE) **Hereditary angioedema (HAE)** is a rare genetic condition causing sudden, painful swelling attacks in areas like the face, hands, feet, genitals, or throat, which can be life-threatening if they block airways. TAKHZYRO is a monoclonal antibody that inhibits plasma kallikrein, reducing HAE attack frequency by preventing bradykinin production, the key driver of swelling.[10] Administered as a subcutaneous injection every 2 weeks (300 mg/2 mL dose), it can be self-injected or given by a caregiver after training. Clinical studies show it significantly lowers attack rates, with many patients experiencing near-complete prevention. Always consult your doctor to confirm if TAKHZYRO is right for your FDA-approved indication.[2][10] Takeda Patient Support provides comprehensive help beyond the drug: insurance navigation, specialty pharmacy coordination, product training (including at-home nursing), and education resources like the 'New to TAKHZYRO' on-demand program for your first 30 days.[1][6][7] ## Who Qualifies for Takeda Patient Support? Takeda offers **two main assistance tracks**: 1. **Co-Pay Assistance Program**: Covers up to **100% of out-of-pocket co-pays**, potentially reducing costs to $5 per dose for eligible patients. Must have **commercial insurance** (including Marketplace plans) – **not Medicare, Medicaid, VA, TRICARE, or other government programs**. Cannot be used if insurance covers 100% or during Medicare Part D coverage gap. Excludes co-pay maximizer plans.[2][8] 2. **Help at Hand (Patient Assistance Program)**: Provides **TAKHZYRO free of charge** to uninsured patients, those awaiting insurance, or those without adequate coverage. Needs-based for U.S. residents (including Puerto Rico); annual reassessment required.[5][8] Support specialists assist everyone, including benefits investigation and appeals help.[1][4] ## Income Eligibility Breakdown Co-Pay Assistance has **no specific income limits** listed but requires commercial insurance and FDA-approved use.[2] Help at Hand is **needs-based** without published FPL thresholds; eligibility determined case-by-case via annual review.[5][8] | Household Size | Co-Pay Program | Help at Hand | |---------------|----------------|--------------| | Individual | Commercial insurance only; no income cap specified | Needs-based (contact for assessment) | | Couple | Commercial insurance only; no income cap specified | Needs-based (contact for assessment) | | Family of 3 | Commercial insurance only; no income cap specified | Needs-based (contact for assessment) | | Family of 4 | Commercial insurance only; no income cap specified | Needs-based (contact for assessment) | | % of FPL | Not applicable | Not specified; case-by-case | *Notes: Call 1-866-888-0660 (Mon-Fri, 8:30 AM-8:00 PM ET) for personalized eligibility check. Programs subject to change.[1][5]* ## Insurance Requirements - **Commercial/Private Insurance**: Eligible for co-pay help (up to 100% coverage).[2] - **Government Insurance (Medicare, Medicaid, etc.)**: Ineligible for co-pay program.[2] - **Uninsured/Underinsured**: Qualify for free drug via Help at Hand while seeking coverage or if none available.[5][8] Takeda helps find insurance plans and refers to nonprofits for premium assistance.[5] If prior authorization (PA) denied, use appeal templates (Formulary Exception, Letter of Intent to Treat, Statement of Medical Necessity).[4] ## Step-by-Step Application Process 1. **Get Prescribed**: Confirm with your doctor that TAKHZYRO is for FDA-approved HAE prophylaxis.[2] 2. **Contact Takeda**: Call **1-866-888-0660** (Mon-Fri, 8:30 AM-8 PM ET) or visit takhzyro.com/support. Specialists handle enrollment, benefits check, and pharmacy coordination.[1][2][5] 3. **Enroll Online or Fax**: - Use the **online portal** for fastest enrollment.[4] - Download/fax forms to **1-855-663-7284** (physician referral starts process).[4][5] 4. **Submit Documents**: Proof of residency, prescription, income (for needs-based), insurance details (if applicable). Exact list confirmed during call.[5] 5. **Specialty Pharmacy**: Takeda coordinates delivery from your designated pharmacy or site-of-care.[1] 6. **Training**: Free at-home administration training and education.[1][7] ## Timeline and Delivery Processing time varies (not specified; typically weeks pending insurance/benefits investigation).[1] Free medication provided while awaiting coverage.[5] Medication ships via specialty pharmacy; track with support team. Refills coordinated automatically; annual reassessment for Help at Hand.[5] ## Alternatives if Denied or Ineligible - **Appeal Denial**: Use Takeda templates and support for PA appeals.[4] - **Other Programs**: Accessia Health for HAE (private insurance).[5] - **Community Resources**: Takeda connects to education and support groups.[2][7] - **Biosimilars**: None currently available.[10] - **Discuss with Doctor**: Alternative HAE prophylactics like C1 inhibitors. ## Disclaimer This guide summarizes publicly available info as of latest data; programs change. Not medical/financial advice. Eligibility not guaranteed. Consult healthcare provider and call Takeda (1-866-888-0660) for current details. Takeda reserves rights to amend/terminate.[1][2][4][5]

Program information last verified: March 30, 2026