Synribo
Generic: omacetaxine mepesuccinate
Manufacturer: Teva · Program:
Apply for assistanceFree to apply. Service from $40/month, payable only when your application is ready to submit.
Eligibility Criteria
Insurance Requirement
See program details
Residency
US residency required
Income Threshold
Up to 300% FPL
Individual Income Limit
$43,740/year
Income limits for generic drugs vary; call to verify
Program Information
Processing Time
2–3 weeks
Delivery Method
shipped to patient or physician office
Application Method
Multiple
Indicated for
Chronic Myeloid Leukemia (CML), TKI-resistant
About This Medication
Teva Cares Foundation Patient Assistance Program Guide: How to Get Synribo (omacetaxine mepesuccinate) at Low or No Cost
Synribo (omacetaxine mepesuccinate) is a prescription medication used to treat adults with chronic or accelerated phase chronic myeloid leukemia (CML) who have resistance or intolerance to two or more tyrosine kinase inhibitors (TKIs).[1][4][10] The Teva Cares Foundation Patient Assistance Program provides eligible patients with Teva medicines, including Synribo, at no cost if they meet specific U.S. residency, insurance, income, and prescription requirements.[2][3][6]
About Synribo
Synribo is injected subcutaneously and is FDA-approved for home administration after preparation by a healthcare professional.[1][4] It targets CML patients who no longer respond to or tolerate standard TKIs. Treatment involves cycles of twice-daily injections for 14 days followed by 28-day rest periods, with adjustments based on response.[10] Teva's SYNCare program complements assistance by offering home delivery of prepared doses via partners like Diplomat Pharmacy or Coram Specialty Pharmacy, supplies for self-administration, injection training, educational resources, and 24/7 support.[1][4][7]
Important safety note: Synribo must be prepared in a healthcare facility; patients or caregivers administer under guidance. Always follow your doctor's instructions and report side effects like low blood counts, infections, or bleeding.[1][10]
Who Qualifies for Teva Cares?
To qualify, you must:
- Reside in the U.S. or its territories.[6]
- Have a valid U.S. prescription for a covered Teva medicine like Synribo.[6]
- Meet income eligibility (specific Federal Poverty Level (FPL) thresholds not detailed publicly; program assesses household income).[2][6]
- Satisfy insurance criteria: uninsured, underinsured, or with coverage that doesn't cover the full cost. No participation in alternative funding programs that require Teva Cares enrollment.[2][6]
Patients with income below 150% FPL need proof of denial from Medicare's Low-Income Subsidy (LIS/Extra Help).[6] The program is free—no fees for application, enrollment, or delivery.[2]
Income Eligibility Breakdown
Teva Cares uses household income relative to FPL, but exact percentages (e.g., 400%, 500%) are not specified in public details—contact the program for your situation.[2][6] Here's a general guide based on 2026 FPL (adjusts annually; verify current levels):
| Household Size | 400% FPL Example (Annual Income) | 500% FPL Example (Annual Income) | Notes |
|---|---|---|---|
| 1 (Individual) | ~$60,320 | ~$75,400 | Proof of LIS denial if <150% FPL [6] |
| 2 (Couple) | ~$81,760 | ~$102,200 | Add ~$21,440 per extra person |
| 3 | ~$103,200 | ~$129,000 | Household income assessed |
| 4 | ~$124,640 | ~$155,800 | Contact for exact thresholds |
Examples approximate; program confirms eligibility. No employer/insurance ties to alternative programs allowed.[2]
Insurance Requirements
Provide details of any health insurance or prescription coverage.[6] Uninsured applicants qualify if other criteria met. Insured patients may be eligible if coverage gaps exist, but prior authorization denial letters are required for incomplete applications.[6] Medicare patients under 150% FPL must show LIS/Extra Help denial.[6] Teva Cares bridges gaps but excludes those in conflicting funding setups.[2]
Step-by-Step Application Process
- Verify eligibility: Review covered medicines on tevacares.org and check residency, insurance, income, prescription.[6]
- Gather documents: Prescription, proof of income (tax returns, pay stubs), insurance details, LIS denial if applicable.[6]
- Complete application: Online at tevacares.org or call 877-237-4881 (Mon-Fri, 9AM-8PM ET) / (844) 796-2273 for Synribo/SYNCare support.[2][6]
- Submit prescription: From U.S. licensed provider; include SYNRIBO Prescription and Services Request Form for SYNCare.[4]
- Healthcare provider role: Doctor may need to submit or coordinate with pharmacy partners like Coram.[4]
- Wait for approval: Program reviews; no processing time specified—call for status.[2]
No fees involved; avoid third-party services charging for help.[2]
Timeline and Delivery
Processing timelines not publicly detailed—expect several weeks; call 877-237-4881 for updates.[2] Once approved, Synribo ships free via SYNCare partners directly to your door with prepared doses and supplies.[1][4] Home administration supported with training and 24/7 hotline.[1] Refills handled through prescription renewals and Coram/Diplomat.[4]
Alternatives if Denied
- Other Teva programs: Call 888-TEVA USA (888-838-2872) for options.[3]
- SYNCare alone: For home support even if not fully free.[1][4]
- PAN Foundation or Good Days: Financial aid for Synribo.[8]
- State assistance or generic alternatives: Consult doctor; no biosimilars listed.[8][10]
- Reapply: Fix issues like missing docs and resubmit.[6]
Disclaimer
This guide is for informational purposes based on publicly available data as of 2026.[1][2][3][4][6] Eligibility, terms, and availability can change—always verify with Teva Cares at 877-237-4881 or tevacares.org. Not medical advice; consult your healthcare provider for treatment decisions. Teva Cares is independent; SYNCare is separate support. Program excludes certain insurances/funding conflicts.[2] Word count: 942.
Program information last verified: March 30, 2026
Ready to apply for Synribo assistance?
ProvisionRX manages the complete application process. Start your application in about 15 minutes.
Need help finding a program?