Symproic

Indicated For

opioid-induced constipation

About This Medication

# Symproic Savings Program Patient Guide: How to Get Symproic (naldemedine) at Low or No Cost Symproic (naldemedine) is a prescription medication used to treat **opioid-induced constipation (OIC)** in adults taking opioid pain medicines for chronic non-cancer pain. This guide explains the **Symproic Savings Program**, a copay assistance offer from manufacturer Shionogi (in partnership with Collegium Pharmaceutical), helping eligible commercially insured patients pay as little as **$0** per prescription, with up to $150 savings per fill.[1][2][3][4] ## About Symproic (naldemedine) Symproic is a once-daily tablet (0.2 mg) that works as a **peripherally-acting mu-opioid receptor antagonist (PAMORA)**. It blocks opioid effects in the gut to relieve constipation without affecting pain relief in the brain. It's approved for adults with OIC who have been on opioids for at least 4 weeks.[1][8][10] **Key facts:** - Take one tablet daily, with or without food. - Stop Symproic if you stop opioids to avoid risks like opioid withdrawal. - Common side effects: stomach pain, diarrhea, nausea. Tell your doctor about any symptoms.[1][8] - It's a Schedule II controlled substance due to structural similarity to naltrexone.[10] Symproic provides relief for the millions affected by OIC, a common issue with long-term opioid use for pain management.[10] ## Who Qualifies for the Symproic Savings Program? This is a **copay savings card program**, not a free drug patient assistance program (PAP) for uninsured or low-income patients. It's designed for **commercially insured patients** (private insurance, not government programs).[1][2][3][4] **Eligibility requirements:** - Valid U.S. prescription for Symproic (20 tablets or more per fill). - Commercial health insurance covering Symproic. - Not enrolled in Medicaid, Medicare Part D, Tricare, VA, DOD, Medigap, or any federal/state healthcare program. - Not using cash-pay discounts or non-insurance plans as primary coverage. - Not in states with 'all payor' anti-kickback laws if insurance pays full cost. - Agree to report card use to any third-party payers and not count savings toward out-of-pocket maximums (e.g., TrOOP for Medicare).[2][4] **Savings details:** - Pay as little as **$0** per 30-day supply. - Up to **$150** off copay/out-of-pocket costs per prescription. - Valid for **up to 13 uses per calendar year**. - Patient covers any amount over $150.[2][4] **Note:** Cash-paying or uninsured patients do not qualify. Contact manufacturer for potential PAP inquiries, though none is detailed here.[5] ## Income Eligibility The Symproic Savings Program has **no income requirements** or Federal Poverty Level (FPL) thresholds. Eligibility is based on insurance type, not finances. This makes it accessible for commercially insured patients regardless of income.[1][2][4] | Household Size | Income Threshold | FPL % | Notes | |---------------|------------------|-------|-------| | Individual | None | None | No income limits; commercial insurance required. | | Couple | None | None | Same as above. | | Family of 3 | None | None | Same as above. | | Family of 4 | None | None | Same as above. | For low-income patients, explore **Medicare Extra Help** (if on Part D): covers premiums, deductibles, and sets low copays (<$12 for Symproic). Income/assets must be below limits.[6][9] ## Insurance Requirements **Must have commercial insurance**; government programs disqualify you.[2][4] - Present savings card at pharmacy with prescription. - Pharmacist processes via BIN: 019158, PCN: CNRX, GRP: AC55907001, ID#: 59933150709.[2] - Invalid with other discounts or if insurance pays 100%. - **Medicare patients:** Cannot use; check Extra Help instead.[2][4][6][9] ## Step-by-Step Application Process 1. **Ask your doctor:** Confirm Symproic prescription (include prescriber ID).[2] 2. **Get the savings card:** Download from symproic.com or call **844-231-2396** to activate.[4] 3. **At the pharmacy:** Show card with prescription. Pharmacist handles processing through Change Healthcare (reimbursement help: 1-800-433-4893).[2] 4. **Questions?** Call **844-SYMPROIC (844-796-7642)**, 8 AM–8 PM ET, Mon–Fri.[4] No online application or documents needed beyond prescription and insurance.[1][4] ## Timeline and Delivery **Instant at pharmacy:** Savings apply immediately upon processing. No waiting or shipping—pick up Symproic like any prescription.[2][4] - Valid up to 13 fills/year. - Program can change/revoke without notice.[4] ## Alternatives if Denied or Ineligible - **Government insurance:** Apply for **Medicare Extra Help** (ssa.gov) or state SPAPs.[5][6] - **Uninsured/low-income:** Inquire with Shionogi/Collegium about PAPs (call 844-SYMPROIC); third-party options like GoodRx or NeedyMeds.[5][6] - **Other savings:** Pharmacy discounts (not combinable), Medicare Payment Plan (spread 2025+ costs).[6] - **Clinical alternatives:** Discuss laxatives, other PAMORAs (e.g., Movantik), or lifestyle changes with your doctor. ## Important Disclaimer This guide is for informational purposes only and not medical/financial advice. Eligibility/terms can change; verify at symproic.com or by calling 844-SYMPROIC. Not valid where prohibited. Consult your healthcare provider before starting Symproic. Manufacturer reserves right to amend/revoke program.[1][2][4]

Program information last verified: March 25, 2026