SYMPROIC

Indicated For

Opioid-induced constipation

About This Medication

# SYMPROIC Savings Program Patient Guide: How to Get SYMPROIC (naldemedine) at Low or No Cost SYMPROIC (naldemedine) is a prescription medication used to treat opioid-induced constipation (OIC) in adults with chronic non-cancer pain, including those taking opioid pain relievers.[1] The **SYMPROIC Savings Program**, offered by manufacturers Shionogi, BioDelivery Sciences, and Collegium Pharmaceutical, helps **eligible commercially insured patients** pay as little as **$0** per 30-day supply, with up to **$150** off co-pays or out-of-pocket costs.[1][2][4] ## About SYMPROIC (naldemedine) **SYMPROIC** is a once-daily tablet that works as a peripherally acting mu-opioid receptor antagonist (PAMORA). It targets opioid receptors in the gut to relieve constipation caused by opioids, without affecting pain relief in the brain. Unlike some alternatives, it can be taken with or without food and does not require a fasting period.[3] Common side uses include abdominal pain, diarrhea, and nausea. Always consult your doctor for personalized advice, as SYMPROIC is not for everyone—especially those with bowel obstructions or severe liver issues.[1] This guide explains how to access the **SYMPROIC Savings Program** to make treatment more affordable. It's designed for patients new to the program or seeking clarity on eligibility and steps. ## Who Qualifies for the SYMPROIC Savings Program? The program is a **copay savings card** primarily for **commercially insured patients** (private insurance, not government programs). Key eligibility: - **Commercially insured** or underinsured individuals. - **U.S. residents** (void where prohibited by law). - **Not cash-paying patients**—insurance must be involved, but the card covers co-pays.[2][4] - Meet all terms; maximum savings is **$150 per prescription**.[1][4] **Important exclusions**: Cannot be used with federal/state programs like **Medicare, Medicaid, Medigap, VA, DOD, TRICARE, or Part D**. Also prohibited in states with 'all payor' anti-kickback laws or if insurance pays 100%.[2][3][4] ## Income Eligibility This is a **copay assistance program**, not a full patient assistance program (PAP) with strict income limits. No specific **Federal Poverty Level (FPL)** thresholds are publicly listed.[Program details] However, manufacturers may offer separate PAPs for uninsured/underinsured with income below undisclosed thresholds—contact (844) 231-2396 to inquire.[3][Program details] | Household Size | Income Threshold | Notes | |---------------|------------------|-------| | Individual | Not disclosed | Income below threshold required for any PAP; copay card has no income test. | | Couple | Not disclosed | Call for details. | | Family of 3 | Not disclosed | Exact limits vary; not for copay card. | | Family of 4 | Not disclosed | Check with manufacturer. | | FPL % | N/A | Copay program income-agnostic for eligible insured. |[Program details] ## Insurance Requirements - **Must have commercial insurance**; card reduces co-pay to **$0 minimum**.[1][2] - **No federal programs**: Explicitly excludes Medicare (including Part D), Medicaid, etc. Medicare patients should explore **Extra Help/LIS**, plan comparisons, or GoodRx discounts.[3][10] - Pharmacist processes primary insurance first, then card as secondary payer.[2] - Report card use to your insurer; do not count toward out-of-pocket maximums like TrOOP.[4] ## Step-by-Step Application Process Getting started is simple and **phone-based**—no online form or documents typically needed for the copay card.[4][9] 1. **Check eligibility**: Visit symproic.com/savings or call (844) 231-2396 (8 AM–8 PM ET, Mon–Fri) to confirm.[1][4][9] 2. **Download or request card**: Get it from symproic.com or your doctor's office.[3][6] 3. **Activate by phone**: Dial **(844) 231-2396**—provide your info to activate.[4][9] 4. **Fill prescription**: Present **activated card + prescription** at pharmacy. BIN: 019158, PCN: CNRX, GRP: AC55907001, ID: 59933150709.[2] 5. **Pharmacist handles rest**: They submit to insurance, then card for up to $150 savings. You pay **$0–$150** max.[1][2] No lengthy applications or mailed docs for standard copay use.[Program details] ## Timeline and Delivery - **Activation**: Instant via phone.[9] - **At pharmacy**: Savings apply **immediately** upon processing—no wait.[2] - **Per fill**: Up to 30-day supply; repeat for refills (no fixed end date listed).[1] - Delivery is standard pharmacy pickup; no special shipping.[Program details] - Program terms may change; call for updates.[4] ## Alternatives if Denied or Ineligible - **Medicare patients**: Apply for **Extra Help** (income/assets below thresholds), compare Part D plans Oct 15–Dec 7, or use pharmacy discounts like GoodRx/ScriptSave WellRx (up to 80% off, Medicare-compatible for non-covered meds).[5][10] - **Uninsured/low-income**: Ask manufacturer about PAPs requiring U.S. residency, no coverage, income screening—may need doctor signature.[3][Program details] - **Other savings**: WellRx, Super.com, or GoodRx coupons; check formulary for generics like naloxegol (Movantik).[5][7] - **Appeal denials**: For prior authorizations, request peer-to-peer review or medical necessity letter.[3] ## Disclaimer This guide is for informational purposes only and based on publicly available data as of 2026. Eligibility, terms, and savings can change—**always verify with (844) 231-2396 or symproic.com**.[1][4] Not medical advice; consult your healthcare provider. Program complies with anti-kickback laws; void where prohibited. Manufacturers reserve right to modify/revoke.[2][4] Word count: 942.

Program information last verified: March 30, 2026