Soliris

Indicated For

Paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), generalized Myasthenia Gravis (gMG), Neuromyelitis Optica Spectrum Disorder (NMOSD)

About This Medication

# Soliris (Eculizumab) Patient Assistance Guide ## Alexion OneSource / AstraZeneca Patient Assistance Program --- ## Who Qualifies for the Alexion OneSource / AstraZeneca Patient Assistance Program? If you take Soliris (eculizumab) and are struggling to afford it, the **Alexion OneSource / AstraZeneca Patient Assistance Program** may be able to help you get your medication free or at a significantly reduced cost. Single-person households with an annual income at or below **$75,300** are typically eligible. Your insurance situation also plays a role: patients who are uninsured or underinsured may qualify for free drug, commercially insured patients may access co-pay assistance, and Medicare patients may be eligible if they meet specific financial hardship criteria. Income and insurance requirements are reviewed together, so even if you are unsure whether you qualify, it is worth applying. RX Advantages can help you navigate the process. --- ## About Soliris (Eculizumab) Soliris (eculizumab) is a prescription biologic medication manufactured by Alexion, an AstraZeneca rare disease company. It belongs to a drug class called complement inhibitors and works by targeting a specific protein in the immune system. Soliris is FDA-approved to treat four serious rare conditions: paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), generalized myasthenia gravis (gMG), and neuromyelitis optica spectrum disorder (NMOSD). Because it is a biologic drug requiring complex manufacturing and ongoing infusion administration, Soliris carries one of the highest list prices of any medication available. Without insurance or assistance, the annual cost can be financially devastating for most patients and families. --- ## Income Eligibility: Full Breakdown The Alexion OneSource program uses income thresholds based on approximately **500% of the Federal Poverty Level (FPL)**. The table below shows the maximum annual income allowed based on your household size: | Household Size | Max Annual Income | |---|---| | 1 person | $75,300 | | 2 persons | $102,200 | | 3 persons | $129,100 | | 4 persons | $156,000 | For households larger than four people, income limits increase with each additional member. Income is typically verified using your most recent federal tax return, a W-2, or a 1099 form. If your income has recently changed, some programs will accept three months of recent pay stubs instead. If your income is above these limits, do not assume you are automatically disqualified. Alexion conducts case-by-case reviews for patients with extraordinary medical expenses or financial hardship. It is still worth submitting an application or calling the program directly at **(888) 765-4747** to ask about exceptions. Program staff can often advise you on whether a review is appropriate for your situation. --- ## Insurance Requirements Explained Your insurance status determines which part of the Alexion OneSource program applies to you: - **If you are uninsured:** You may qualify for the free drug program. You will need to provide documentation confirming you do not have active prescription drug coverage. - **If you have Medicare Part D:** Most standard patient assistance programs exclude Medicare beneficiaries due to federal regulations. However, Alexion's rare disease program may make exceptions for Medicare patients who can demonstrate specific financial hardship. Call **(888) 765-4747** to discuss your eligibility directly. - **If you have private (commercial) insurance that leaves you with high out-of-pocket costs:** You may qualify for the co-pay assistance program rather than the free drug program. This can significantly reduce or eliminate your share of costs. Visit [https://alexiononesource.com/copay-assistance](https://alexiononesource.com/copay-assistance) for the savings card. - **If you have Medicaid:** Medicaid typically covers Soliris as a medically necessary drug. If Medicaid is covering your costs, you would generally not qualify for the free drug program, but you should contact the program to clarify your specific situation. --- ## Step-by-Step: How to Apply Follow these steps to apply for the Alexion OneSource / AstraZeneca Patient Assistance Program: 1. **Gather your documents before you start.** You will need: proof of income (most recent tax return, W-2, or 1099), your insurance card or a denial letter from your insurer, your prescriber's contact information and a current prescription for Soliris, and a signed patient consent form. 2. **Choose your application method.** You can apply online at [https://alexiononesource.com/](https://alexiononesource.com/), call the program at **(888) 765-4747** to apply by phone or request paper forms, or fax a completed application to **(800) 420-7557**. 3. **Complete the application fully.** Incomplete applications are a common reason for delays. Double-check that all fields are filled in and that your prescriber has signed where required. 4. **Submit your supporting documents** along with your application. If applying online, upload scanned or photographed copies. If faxing, send all documents together in one transmission. 5. **Confirm receipt.** After submitting, call **(888) 765-4747** to confirm your application was received and to ask about your case status. 6. **Your prescriber will be notified** of the approval decision. If approved, medication will be arranged for shipment directly to your prescriber's office. --- ## What to Expect: Timeline and Delivery After submitting a complete application, processing typically takes **7 to 10 business days**. Alexion OneSource will notify your prescriber of the approval decision. Soliris is shipped directly to your **prescriber's office or infusion center**, not to your home, since it is administered by a healthcare provider. You do not need to pick up or transport the medication yourself. Once approved, your enrollment is valid for **one year**, after which you must reauthorize. Alexion will typically send a reauthorization reminder before your approval expires, but it is a good idea to track your renewal date so there is no interruption in your treatment. --- ## Alternatives If You Don't Qualify If you do not meet the income or insurance requirements for the free drug program, you still have options: 1. **Biosimilar alternatives:** Two FDA-approved biosimilars to Soliris are available and may be covered at a lower cost — **Beksomy (eculizumab-aeeb)** and **Epysqli (eculizumab-aagh)**. Ask your prescriber if either may be appropriate for you. 2. **Co-pay savings card:** If you have commercial insurance, Alexion offers a savings card program that can reduce your out-of-pocket costs. Apply at [https://alexiononesource.com/copay-assistance](https://alexiononesource.com/copay-assistance). 3. **State Pharmaceutical Assistance Programs (SPAPs):** Many states offer additional drug assistance for residents who do not qualify for federal programs. Contact your state health department to ask what is available in your state. 4. **NeedyMeds.org:** This free, independent database lists hundreds of patient assistance programs, disease-specific funds, and drug discount options. It is a helpful starting point if you are exploring multiple avenues. --- > *This guide is for informational purposes only and does not constitute medical or legal advice. Eligibility determinations are made solely by Alexion / AstraZeneca. Program terms may change — verify current requirements at [https://www.alexion.com/patients/patient-assistance-programs](https://www.alexion.com/patients/patient-assistance-programs) before applying.* ---

Program information last verified: February 27, 2026