Signifor

Indicated For

Cushing's disease

About This Medication

# R.A.R.E. Patient Support Program Patient Guide: How to Get Signifor (pasireotide) at Low or No Cost The **R.A.R.E. Patient Support Program** from **Novartis** helps eligible patients access **Signifor (pasireotide)**, a medication used to treat Cushing's disease in adults who cannot undergo pituitary surgery or for whom surgery was not successful. This guide explains eligibility, application steps, and support options in simple terms.[1][2] ## About Signifor (pasireotide) **Signifor (pasireotide)** is an injectable medication that works by reducing ACTH production from pituitary tumors, helping control symptoms of Cushing's disease like high cortisol levels. It's typically given twice daily via subcutaneous injection. Common side effects include diarrhea, nausea, headache, and increased blood sugar—discuss risks with your doctor. Always follow your healthcare provider's instructions for safe use.[1] ## Who Qualifies for the Program? The R.A.R.E. Patient Support Program targets patients with rare diseases facing financial barriers. Key requirements include: - Residing in the US or a US Territory. - Having a valid prescription for Signifor from a licensed US healthcare provider. - Receiving treatment on an outpatient basis. - Meeting **needs-based income guidelines** (specific thresholds not publicly listed; contact program for details). - Limited or no prescription insurance coverage (uninsured or underinsured qualify; coverage not required).[1][2][3] **Eligibility is determined case-by-case.** Restrictions, limitations, and other requirements apply. Visit www.PAP.Novartis.com or call (888) 855-7273 to check if you qualify.[2][3] ## Income Eligibility Breakdown This program uses **needs-based criteria** rather than fixed Federal Poverty Level (FPL) percentages. Exact thresholds for individuals, couples, or families are not specified publicly—you must contact the program.[1] Here's a summary table: | Household Type | Income Threshold | Notes | |---------------|------------------|-------| | Individual | Contact program | Needs-based; proof required (e.g., first 2 pages of 1040 tax return) | | Couple | Contact program | Household size from tax return (1040) | | Family of 3 | Contact program | If no tax filing required, call for alternatives | | Family of 4+ | Contact program | Submit most recent proof of income |[1][2] Provide accurate income documentation to avoid delays or denial. The program verifies information at its discretion.[3] ## Insurance Requirements - **Uninsured or underinsured** patients are eligible—no insurance required. - If insured, submit copies of **all insurance cards (front and back)**, including primary, secondary, prescription, Medicare (Red/White/Blue card), and any Part D/Advantage plans. - For insured patients needing **Prior Authorization (PA)**, include PA approval, denial, or appeal outcomes. - Government insurance like Medicare does not automatically disqualify you, but full details are needed.[1][2] The program coordinates with insurance but focuses on those with limited coverage.[3] ## Step-by-Step Application Process 1. **Check Eligibility**: Visit www.PAP.Novartis.com or call **(888) 855-7273** to confirm you may qualify.[3] 2. **Gather Documents**: - **Patient referral form** (completed Start Form from Novartis).[1] - Proof of income: First 2 pages of latest **1040 tax return** (or contact if not required).[1][2] - Insurance cards (front/back) if applicable. - Prescriber section: Doctor completes attestation, signs, and faxes separate prescription.[1][2] 3. **Complete Application**: Patient and healthcare provider (HCP) fill out sections. Sign patient authorization.[1] 4. **Submit**: - **Phone**: (888) 855-7273 for guidance.[1] - **Fax**: 1-855-817-2711 (complete form required).[1][2] - **Mail**: NPAF, PO Box 2529, Columbus, OH 43216 (or updated address).[1] Multiple methods available—choose what's easiest.[1] 5. **Follow Up**: Opt in for texts/calls. Incomplete apps delay processing.[1][3] Your doctor must authorize the therapy as medically necessary.[1] ## Timeline and Delivery - **Processing**: Expect a decision letter within **4 weeks**. Texts may notify of next steps if incomplete.[3] - If approved, medication is **shipped through specialty pharmacy network (Anovo Specialty Pharmacy)**. E-scribe directions provided to prescriber.[1] - No specific reauthorization details listed—contact program for refill process.[1] Stay in touch via provided mobile number for updates.[1] ## Alternatives if Denied - **Appeal**: Review denial letter; resubmit missing info or updated documents.[3] - **Other Novartis Programs**: Check Novartis Patient Support for co-pay help if commercially insured (not for government insurance).[4][9] - **General Resources**: State programs, NeedyMeds, or PAN Foundation. Search www.PAP.Novartis.com for other options.[2] - **Contact NPAF**: Call 800-277-2254 for guidance on next steps.[2][6] - No biosimilar alternatives for Signifor listed.[1] ## Important Disclaimer This guide is for informational purposes only and based on available program details as of latest updates. **Eligibility requirements, restrictions, and limitations apply.** Novartis or NPAF may change, verify, or discontinue the program at any time. It does not guarantee approval. Consult your healthcare provider and contact the program directly at (888) 855-7273 or www.PAP.Novartis.com for personalized advice. Not a substitute for medical or legal counsel. Program prohibits enrollment by health plans or agents—only patients/guardians.[1][2][3]

Program information last verified: March 29, 2026