Signifor LAR

Indicated For

acromegaly, Cushing's disease

About This Medication

# R.A.R.E. Patient Support Program Patient Guide: How to Get Signifor LAR at Low or No Cost Signifor LAR (pasireotide) is a prescription medication used to treat **acromegaly** and **Cushing’s disease** in adults for whom surgery has not worked well enough or who cannot have surgery. The **R.A.R.E. Patient Support Program** from Recordati Rare Diseases helps eligible uninsured or underinsured patients access Signifor LAR at low or no cost through financial assistance, while also offering support for insured patients via copay programs.[1][2][7] ## About Signifor LAR Signifor LAR is a **long-acting release (LAR)** injectable form of pasireotide, a somatostatin analog that helps control hormone levels. For **acromegaly**, it reduces excess growth hormone (GH) and insulin-like growth factor 1 (IGF-1). In **Cushing’s disease**, it lowers adrenocorticotropic hormone (ACTH) production from pituitary tumors, reducing cortisol levels to ease symptoms like weight gain, high blood pressure, and fatigue.[3][7] It is given as an **intramuscular injection** once every 4 weeks by a healthcare professional, unlike the daily subcutaneous version (Signifor). Common side effects include diarrhea, nausea, headache, abdominal pain, fatigue, and increased blood sugar levels. Serious risks involve **QT interval prolongation** (heart rhythm issues), **hyperglycemia** (high blood sugar), **liver function changes**, and **pituitary hormone deficiencies**. Your doctor will monitor you with blood tests before and during treatment.[7] Always discuss benefits and risks with your healthcare provider. This guide focuses on accessing the medication affordably, not medical advice. ## Who Qualifies for the R.A.R.E. Patient Support Program? The program targets **needs-based eligibility** for uninsured, underinsured, or indigent patients facing financial barriers to Signifor LAR. Commercially insured patients may qualify for a separate **copay assistance program** to lower out-of-pocket costs. Medicare or Medicaid patients should check specific eligibility, as restrictions apply.[1][2][8] **Key eligibility factors**: - Financial need (proof required; exact income thresholds not publicly specified—contact program for personalized assessment). - Residency in the US. - Valid prescription for Signifor LAR. - Willingness to provide documentation.[1][6] The program fills prescriptions through a **specialty pharmacy network (Anovo Specialty Pharmacy)** and offers additional support like insurance verification, prior authorization help, nurse education, and bridge programs during coverage gaps.[1][2][6] ## Income Eligibility Breakdown Income eligibility is **needs-based** without fixed Federal Poverty Level (FPL) percentages listed publicly. Patients must submit proof of income for review. Here's a general overview based on similar programs; call (888) 855-7273 for your situation: | Household Size | Estimated Max Income (as % of FPL) | Notes | |---------------|-----------------------------------|-------| | Individual | Contact program | Needs-based; varies by assets, expenses[1] | | Couple | Contact program | Proof of all income sources required | | Family of 3 | Contact program | Includes dependents; full financial picture assessed | | Family of 4+ | Contact program | Larger families may have flexibility | *Table is illustrative—**eligibility is determined case-by-case**. Independent foundations may assist if ineligible.[1][2] ## Insurance Requirements - **Uninsured or underinsured**: Primary candidates for free or low-cost medication via the Patient Assistance Program (PAP).[1][2] - **Commercially insured**: Eligible for **Copay Assistance Program** (restrictions apply; not for government insurance).[1][9] - **Medicare/Medicaid**: May not qualify for PAP or copay help; explore other options like state programs or Simplefill.[3][5] The program verifies benefits, handles prior authorizations, and provides financial bridge support during appeals or gaps.[2] ## Step-by-Step Application Process 1. **Get Prescribed**: Ask your doctor for Signifor LAR and discuss the R.A.R.E. program.[7] 2. **Download/Request Forms**: Use the **Patient Referral Form** (includes prescription, insurance details, clinical info). Available on signiforlar.com or via phone.[4][6][10] 3. **Gather Documents**: - **Proof of income** (tax returns, pay stubs, W-2s). - **Proof of insurance status** (insurance card copies or denial letters). - **Prescription** from your doctor. - **Patient Referral Form** completed by prescriber.[6] 4. **Submit**: Fax form directly from prescriber to AnovoRx at 855-813-2039 or call (888) 855-7273 (Mon-Fri, 9AM-6PM ET).[2][6] 5. **Program Review**: Case managers verify eligibility, handle insurance if needed.[1] 6. **Approval Notification**: You'll be contacted; medication shipped if approved.[1] **Pro Tip**: Specify home administration preference for nursing support or supplies (syringes, needles, sharps container).[6] ## Timeline and Delivery Processing time varies (not specified; typically 1-4 weeks based on similar programs). Expect benefits verification first, then approval/denial. Approved meds are **shipped via Anovo Specialty Pharmacy network**—direct to your home or doctor's office. Refills require **reauthorization**; your doctor resubmits periodically.[1][2][6] **Contact Hours**: Mon-Fri, 8AM-8PM ET (some sources say 9AM-6PM).[2][4] ## Alternatives if Denied - **Copay Program** (if commercially insured).[1] - **Independent charities** (program helps identify).[1][2] - **Simplefill** or other aggregators for additional PAPs.[3] - **Patient Access Network (PAN) Foundation** or state assistance. - **Appeal** denial or reapply with updated docs. - No **biosimilar alternatives** available for Signifor LAR.[3] Discuss with your doctor; they can leverage reimbursement support.[1] ## Disclaimer This guide is for informational purposes based on publicly available data as of 2026. **Eligibility, terms, and availability can change**—**always verify directly with R.A.R.E. at (888) 855-7273**. Not medical or legal advice. Consult your healthcare provider for treatment decisions. Program restrictions/limitations apply; not guaranteed.[1][2]

Program information last verified: March 30, 2026