RYSTIGGO

Indicated For

Generalized myasthenia gravis (gMG)

About This Medication

# ONWARD Patient Assistance Program Patient Guide: How to Get RYSTIGGO (rozanolixizumab-noli) at Low or No Cost RYSTIGGO (rozanolixizumab-noli) is an FDA-approved subcutaneous infusion treatment for adults with generalized myasthenia gravis (gMG), a chronic autoimmune neuromuscular disease causing muscle weakness.[1][2][3] The **ONWARD Patient Assistance Program** from UCB Pharma helps eligible patients access RYSTIGGO at low or no cost through copay assistance for commercially insured patients and free medication for uninsured or underinsured individuals.[1][2][4][8] ## About RYSTIGGO and Generalized Myasthenia Gravis (gMG) **RYSTIGGO** is a monoclonal antibody that targets and reduces IgG antibodies causing muscle weakness in gMG.[3] Administered via weekly or biweekly subcutaneous infusions (under the skin) at a healthcare site or potentially at home under supervision, it helps improve daily activities like chewing, swallowing, breathing, and limb strength.[2][5] Clinical trials showed significant improvements in muscle strength and quality of life within weeks.[3] gMG affects about 20 per 100,000 people, more commonly women under 40 and men over 60. Symptoms fluctuate but can disrupt life profoundly. Always consult your doctor for personalized advice—ONWARD Care Coordinators provide support, not medical advice.[2][3][10] ## Who Qualifies for ONWARD Assistance? ONWARD offers **personalized support** including **Patient Assistance Program (PAP)** for free RYSTIGGO (up to 12 months for eligible patients) and copay help.[1][4][8] It's for US residents (including Puerto Rico) with a valid prescription from a licensed US provider.[4] - **Uninsured or underinsured**: Primary candidates for PAP—free medication if you meet financial need.[2][4][8] - **Commercially insured**: Copay assistance to lower out-of-pocket costs.[1][9] **Not eligible**: Medicare Part D, Medigap, Medicaid, state programs, TRICARE, VA, or DoD patients.[1] Traditional Medicare often has open access (100% no prior auth), with Medigap covering 0 out-of-pocket; Medicare Advantage >98% access.[3] ## Income Eligibility Breakdown Specific income thresholds aren't publicly detailed—eligibility is **needs-based** and evaluated individually by ONWARD.[1][4][7] Contact (844) 669-2731 for your situation. Here's a general guide based on similar UCB programs (confirm with ONWARD): | Household Size | Annual Income Limit (300% FPL example)* | Notes | |---------------|---------------------------------------|-------| | 1 | ~$45,000 | Flexible; proof required | | 2 | ~$61,000 | Uninsured/underinsured priority | | 3 | ~$77,000 | Individual assessment | | 4 | ~$93,000 | Add ~$16,000 per person | *Federal Poverty Level (FPL) approximate for 2026; actuals vary. No income docs listed, but expect paystubs/tax returns.[1][4] ## Insurance Requirements - **Commercial insurance**: >97% have access; copay cards reduce costs (submit EOB for claims).[3][9] - **Uninsured/underinsured**: PAP provides free drug.[8] - **Government insurance**: Excluded from assistance; good Medicare access noted.[1][3] ONWARD's Care Coordinator investigates benefits first.[2][5][10] ## Step-by-Step Application Process 1. **Discuss with your doctor**: Ask about ONWARD during your visit.[1][6] 2. **Download/complete Start Form**: Get from ucbONWARD.com/RYSTIGGO or doctor. Fill patient info, sign authorizations (email/text consent optional), check services like PAP.[1][2] 3. **Doctor completes/signs**: Includes prescription, services requested (e.g., Benefit Investigation, PAP).[1][6] 4. **Submit**: Doctor faxes to 1-833-329-8221 or e-enrolls online.[1][6] 5. **Alternative: Call ONWARD**: Dial (844) 669-2731 to start—mention RYSTIGGO.[2][10] 6. **Expect call**: ONWARD Care Coordinator contacts you (caller ID: "ONWARD") to discuss coverage, finances, schedule.[1][2][5] 7. **Enroll in PAP if eligible**: Coordinator guides financial review.[4][8] You're assigned a dedicated, medically trained **Care Coordinator** for ongoing help: insurance navigation, symptom tracking, infusion setup.[2][3][10] ## Timeline and Delivery - **Processing**: Varies; coordinator calls soon after submission. Benefits investigation quick.[5] - **Approval**: Individual; PAP up to 12 months free.[8] - **Delivery**: Shipped to patient or infusion site. First treatment scheduled post-coverage confirmation.[1][5] - **Refills**: **Reauthorization required**—reauth form similar process.[1] Prepare: Confirm costs, locate infusion site, arrange transport.[5] ## Alternatives if Denied - **Appeal support**: ONWARD helps with PA/denials.[1] - **Copay program**: If commercial insurance qualifies.[9] - **Infusion center assistance**: Some sites offer sliding scales.[3] - **Other foundations**: NeedyMeds, PAN Foundation (check gMG funds). - **State programs**: If not excluded. - **Biosimilars**: None currently.[1] Contact coordinator for options.[2] ## Important Disclaimer This guide summarizes publicly available info as of 2026; programs change.[2] ONWARD may amend/cancel anytime; restrictions apply.[2][3] Not medical/financial advice—verify with ONWARD at (844) 669-2731 or doctor. Eligibility not guaranteed. UCB/RYSTIGGO trademarks of UCB Group.[1] (Word count: 942)

Program information last verified: March 30, 2026