RUXIENCE

Indicated For

Non-Hodgkin’s Lymphoma (NHL), Chronic Lymphocytic Leukemia (CLL), Rheumatoid Arthritis (RA), Granulomatosis with Polyangiitis (GPA), Microscopic Polyangiitis (MPA)

About This Medication

# Pfizer Oncology Together & enCompass Patient Guide: How to Get RUXIENCE (rituximab-pvvr) at Low or No Cost RUXIENCE (rituximab-pvvr) is a biosimilar monoclonal antibody used to treat certain cancers and autoimmune conditions, and Pfizer offers support through programs like **Pfizer Oncology Together Co-Pay Savings**, **Pfizer enCompass Co-Pay Assistance**, and the **Pfizer Patient Assistance Program (RxPathways)** to help eligible patients reduce or eliminate costs.[1][2][5][7] ## About RUXIENCE and Why Assistance Matters **RUXIENCE (rituximab-pvvr)** is an injectable biosimilar to Rituxan, approved for FDA-indicated uses including: - **Non-Hodgkin’s Lymphoma (NHL)**: Relapsed or refractory low-grade or follicular CD20-positive B-cell NHL (as single agent), previously untreated follicular NHL (with chemotherapy), and more.[4] - **Rheumatoid Arthritis (RA)**: Combined with methotrexate for moderate-to-severe active RA after TNF antagonist failure.[4] - **Granulomatosis with Polyangiitis (GPA) and Microscopic Polyangiitis (MPA)**: With glucocorticoids.[4] As an oncology and specialty injectable, RUXIENCE can be expensive without support. Pfizer's programs aim to make it accessible by covering co-pays for commercially insured patients or providing free medicine for uninsured/underinsured patients meeting income limits.[1][5][7] ## Who Qualifies? Pfizer has **two main paths** for RUXIENCE: 1. **Co-Pay Programs (Pfizer Oncology Together & enCompass)**: For **commercially insured** patients (private insurance, not government-funded).[1][5] - Pay **as low as $0 per treatment**. - Annual cap: **$25,000** savings per calendar year.[1][5] - **Exclusions**: Medicare, Medicaid, TRICARE, VA, cash-pay patients, or pemphigus vulgaris indication.[1] 2. **Pfizer Patient Assistance Program (RxPathways)**: For **uninsured or government underinsured** patients.[7] - Free medicine if eligible. - Income up to **500%-600% FPL** for oncology/specialty products like RUXIENCE (varies by household size).[7] - Must have valid US prescription, outpatient treatment, FDA-approved indication.[7] **Note**: Commercially insured patients use co-pay programs; uninsured/underinsured use RxPathways. Medicare patients generally ineligible for co-pay but may qualify for RxPathways if underinsured.[1][7] ## Income Eligibility Breakdown | Household Size | 100% FPL | Co-Pay Programs (No income limit) | RxPathways (Up to 500-600% FPL)* | |---------------|----------|-----------------------------------|----------------------------------| | 1 (Individual)| $15,060 | All eligible commercially insured | Up to $75,300-$90,360[7] | | 2 (Couple) | $20,440 | All eligible commercially insured | Up to $102,200-$122,640[7] | | 3 | $25,820 | All eligible commercially insured | Up to $129,100-$154,920[7] | | 4 | $31,200 | All eligible commercially insured | Up to $156,000-$187,200[7] | *FPL figures approximate for 2026; RxPathways uses 500-600% for oncology. Confirm current levels. Co-pay has **no income eligibility**.[1][7] ## Insurance Requirements - **Co-Pay Programs**: Must have **commercial/private insurance** covering RUXIENCE. Not for government insurance (Medicare, Medicaid, etc.) or cash-pay.[1][5] - **RxPathways**: **Uninsured** or **government underinsured** (e.g., Medicare Part D with high costs). Commercially insured ineligible.[7] - **Not valid** if insurance fully reimburses RUXIENCE.[1] ## Step-by-Step Application Process ### For Co-Pay Assistance (Commercial Insurance): 1. **Confirm eligibility**: Private insurance covering RUXIENCE, not government programs.[1] 2. **Visit provider sites**: Use [Pfizer Oncology Together](https://ruxience.pfizerpro.com/savings-support/co-pay-assistance) or [Pfizer enCompass](https://www.pfizerencompassresources.com).[1][5] 3. **Enroll**: HCP completes **Pfizer enCompass Enrollment Form** (download PDF), faxes to 1-844-482-4482 or mails to Pfizer enCompass, 2730 S. Edmonds Lane Suite 300, Lewisville, TX 75067.[10] 4. **Activate card**: Get savings card at activation portal or call **1-844-722-6672** (Mon-Fri 8am-8pm ET).[5][10] 5. **Use at infusion**: Present card at treatment site for $0 co-pay (up to $25,000/year).[1] ### For Free Medicine (RxPathways, Uninsured/Underinsured): 1. **Check pfizerrxpathways.com** or call program.[7] 2. **HCP submits enrollment form** with prescription.[7] 3. **Provide proof of income**: W2, tax return, paystub.[7] 4. **May need to apply for other aid first**.[7] 5. **Medicine shipped** to doctor’s office or home.[7] **Call 1-844-722-6672** for both programs to start.[5][10] ## Timeline and Delivery - **Co-Pay**: Instant activation; use immediately at infusion center. Annual cap applies.[1] - **RxPathways**: Processing varies (days to weeks); delivery to HCP office or home.[7] - **enCompass**: HCP portal tracks status; counselors assist.[5] Contact **1-844-722-6672** for updates (Mon-Fri 8am-8pm ET).[5] ## Alternatives if Denied or Ineligible - **Switch programs**: Commercial → RxPathways if uninsured.[7] - **Pfizer Institutional Program**: Free via clinics/health centers for ≤300% FPL uninsured.[7] - **Other resources**: Pfizer Oncology Together connects to external aid.[2][4] - **Biosimilars**: No specific alternatives listed; discuss with HCP.[ ] - **Appeal**: Contact 1-844-722-6672 for review.[5] ## Disclaimer This guide summarizes publicly available info as of 2026. **Eligibility, terms, FPL levels change**; confirm with Pfizer at **1-844-722-6672** or websites. Not medical/financial advice. Consult HCP/insurer. Programs may end; limits apply. Pfizer not liable for errors.[1][5][7]

Program information last verified: March 30, 2026