RUXIENCE

Pfizer Oncology Together & enCompass Patient Guide: How to Get RUXIENCE (rituximab-pvvr) at Low or No Cost

RUXIENCE (rituximab-pvvr) is a biosimilar monoclonal antibody used to treat certain cancers and autoimmune conditions, and Pfizer offers support through programs like Pfizer Oncology Together Co-Pay Savings, Pfizer enCompass Co-Pay Assistance, and the Pfizer Patient Assistance Program (RxPathways) to help eligible patients reduce or eliminate costs.[1][2][5][7]

About RUXIENCE and Why Assistance Matters

RUXIENCE (rituximab-pvvr) is an injectable biosimilar to Rituxan, approved for FDA-indicated uses including:

• Non-Hodgkin’s Lymphoma (NHL): Relapsed or refractory low-grade or follicular CD20-positive B-cell NHL (as single agent), previously untreated follicular NHL (with chemotherapy), and more.[4]
• Rheumatoid Arthritis (RA): Combined with methotrexate for moderate-to-severe active RA after TNF antagonist failure.[4]
• Granulomatosis with Polyangiitis (GPA) and Microscopic Polyangiitis (MPA): With glucocorticoids.[4]

As an oncology and specialty injectable, RUXIENCE can be expensive without support. Pfizer's programs aim to make it accessible by covering co-pays for commercially insured patients or providing free medicine for uninsured/underinsured patients meeting income limits.[1][5][7]

Who Qualifies?

Pfizer has two main paths for RUXIENCE:

1. Co-Pay Programs (Pfizer Oncology Together & enCompass): For commercially insured patients (private insurance, not government-funded).[1][5]

   • Pay as low as $0 per treatment.
   • Annual cap: $25,000 savings per calendar year.[1][5]
   • Exclusions: Medicare, Medicaid, TRICARE, VA, cash-pay patients, or pemphigus vulgaris indication.[1]

2. Pfizer Patient Assistance Program (RxPathways): For uninsured or government underinsured patients.[7]

   • Free medicine if eligible.
   • Income up to 500%-600% FPL for oncology/specialty products like RUXIENCE (varies by household size).[7]
   • Must have valid US prescription, outpatient treatment, FDA-approved indication.[7]

Note: Commercially insured patients use co-pay programs; uninsured/underinsured use RxPathways. Medicare patients generally ineligible for co-pay but may qualify for RxPathways if underinsured.[1][7]

Income Eligibility Breakdown

*FPL figures approximate for 2026; RxPathways uses 500-600% for oncology. Confirm current levels. Co-pay has no income eligibility.[1][7]

Insurance Requirements

• Co-Pay Programs: Must have commercial/private insurance covering RUXIENCE. Not for government insurance (Medicare, Medicaid, etc.) or cash-pay.[1][5]
• RxPathways: Uninsured or government underinsured (e.g., Medicare Part D with high costs). Commercially insured ineligible.[7]
• Not valid if insurance fully reimburses RUXIENCE.[1]

Step-by-Step Application Process

For Co-Pay Assistance (Commercial Insurance):

1. Confirm eligibility: Private insurance covering RUXIENCE, not government programs.[1]
2. Visit provider sites: Use Pfizer Oncology Together or Pfizer enCompass.[1][5]
3. Enroll: HCP completes Pfizer enCompass Enrollment Form (download PDF), faxes to 1-844-482-4482 or mails to Pfizer enCompass, 2730 S. Edmonds Lane Suite 300, Lewisville, TX 75067.[10]
4. Activate card: Get savings card at activation portal or call 1-844-722-6672 (Mon-Fri 8am-8pm ET).[5][10]
5. Use at infusion: Present card at treatment site for $0 co-pay (up to $25,000/year).[1]

For Free Medicine (RxPathways, Uninsured/Underinsured):

1. Check pfizerrxpathways.com or call program.[7]
2. HCP submits enrollment form with prescription.[7]
3. Provide proof of income: W2, tax return, paystub.[7]
4. May need to apply for other aid first.[7]
5. Medicine shipped to doctor’s office or home.[7]

Call 1-844-722-6672 for both programs to start.[5][10]

Timeline and Delivery

• Co-Pay: Instant activation; use immediately at infusion center. Annual cap applies.[1]
• RxPathways: Processing varies (days to weeks); delivery to HCP office or home.[7]
• enCompass: HCP portal tracks status; counselors assist.[5]

Contact 1-844-722-6672 for updates (Mon-Fri 8am-8pm ET).[5]

Alternatives if Denied or Ineligible

• Switch programs: Commercial → RxPathways if uninsured.[7]
• Pfizer Institutional Program: Free via clinics/health centers for ≤300% FPL uninsured.[7]
• Other resources: Pfizer Oncology Together connects to external aid.[2][4]
• Biosimilars: No specific alternatives listed; discuss with HCP.[ ]
• Appeal: Contact 1-844-722-6672 for review.[5]

Disclaimer

This guide summarizes publicly available info as of 2026. Eligibility, terms, FPL levels change; confirm with Pfizer at 1-844-722-6672 or websites. Not medical/financial advice. Consult HCP/insurer. Programs may end; limits apply. Pfizer not liable for errors.[1][5][7]