Relyvrio

Indicated For

Amyotrophic Lateral Sclerosis (ALS)

About This Medication

# Patient Guide: How to Get RELYVRIO at Low or No Cost ## Important Notice About RELYVRIO Assistance RELYVRIO (sodium phenylbutyrate and taurursodiol) is a medication used to treat ALS (amyotrophic lateral sclerosis). While Amylyx Pharmaceuticals, the manufacturer, does not currently have an active prescription assistance program (PAP), there are several other ways to help reduce the cost of this medication. ## About RELYVRIO RELYVRIO is a fixed-dose combination therapy containing two active ingredients designed to help slow the progression of ALS. Because ALS is a serious and life-threatening condition, access to this medication is important for many patients. The typical cost of RELYVRIO can be significant, but multiple resources exist to help make it more affordable. ## Why There's No Active Manufacturer Program Right Now Amylyx Pharmaceuticals has not established an active patient assistance program for RELYVRIO at this time. This can change, so it's worth checking back periodically or contacting the manufacturer directly to ask about future program availability. However, this does NOT mean you're without options. ## Alternative Ways to Get Help Paying for RELYVRIO ### 1. Check Your Insurance Coverage Your health insurance may cover RELYVRIO, either through: - **Medicare Part D** (if you're eligible) - **Medicaid** (varies by state) - **Commercial insurance plans** - **VA benefits** (if you're a veteran) Contact your insurance company to: - Confirm if RELYVRIO is covered - Find out your copay, coinsurance, or deductible amount - Ask about prior authorization requirements - Inquire about any step therapy requirements ### 2. Patient Assistance Organizations Several nonprofit organizations help ALS patients access medications: **ALS Association** - Phone: 1-800-782-4747 - Website: www.als.org - Offers grants and resources for medication costs **ALS Therapy Development Institute** - Provides financial assistance information - Connects patients with available resources **NeedyMeds.org** - Free online database of patient assistance programs - Updated regularly with available programs - Search for RELYVRIO and your state for specific options ### 3. State Pharmaceutical Assistance Programs (SPAPs) Most states have programs that help residents afford prescription medications: - Income requirements vary by state - Typically available to people with incomes between 150-300% of federal poverty level - Provide free or reduced-cost medications - Search for your state's program on the National Association of State Pharmaceutical Assistance Programs (NASAP) website ### 4. Hospital and Clinic Resources If you receive care at an ALS clinic or major medical center: - Ask your healthcare team about assistance programs - Speak with a social worker or financial counselor - They may know of local or regional resources - Some hospitals have their own charity care programs ### 5. Specialty Pharmacy Programs RELYVRIO is distributed through specialty pharmacies. These pharmacies often have: - Patient support services - Financial assistance coordinators - Connections to manufacturer rebate programs (if they become available) - Knowledge of insurance coverage options ## Income Eligibility and Financial Assistance While specific manufacturer programs aren't currently active, most alternative resources use income guidelines. Here's a general reference for 2024 federal poverty levels: | Household Size | Federal Poverty Level | 150% of FPL | 200% of FPL | 300% of FPL | |---|---|---|---|---| | 1 person | $14,580 | $21,870 | $29,160 | $43,740 | | 2 people | $19,720 | $29,580 | $39,440 | $59,160 | | 3 people | $24,860 | $37,290 | $49,720 | $74,580 | | 4 people | $30,000 | $45,000 | $60,000 | $90,000 | | 5 people | $35,140 | $52,710 | $70,280 | $105,420 | *Note: These are guidelines. Actual eligibility varies by program and state. Some programs have no income limits.* ## Steps to Access Affordable RELYVRIO ### Step 1: Gather Your Information Collect the following before contacting programs: - Your household income (recent tax return or pay stubs) - Household size and composition - Current insurance information (if you have it) - Your doctor's prescription for RELYVRIO - Insurance denial letters (if applicable) ### Step 2: Contact Your Insurance Company Start here first: - Ask if RELYVRIO is covered - Request information about your cost-sharing - Ask about prior authorization or step therapy - Get the decision in writing ### Step 3: Reach Out to Assistance Organizations - Contact the ALS Association (1-800-782-4747) - Search NeedyMeds.org for programs in your state - Ask your healthcare provider's social worker for referrals ### Step 4: Apply to State Programs - Visit your state health department website - Look for pharmaceutical assistance program information - Complete applications as directed - Provide required income documentation ### Step 5: Contact Specialty Pharmacy Support - Ask your pharmacy about patient support services - Inquire about any available rebates or discounts - Ask about alternative programs they know about ### Step 6: Follow Up Regularly - Check back with the manufacturer periodically - Ask about newly available programs - Reapply annually to state programs ## What to Expect: Timeline and Delivery **Processing Time:** Most assistance programs take 4-8 weeks to process applications, though this varies: - Some programs process faster (2-4 weeks) - Others may take longer (up to 12 weeks) - Emergency programs may be available for urgent situations **Medication Delivery:** - Specialty pharmacies typically mail medications to your home - Insurance coverage means picking up at your pharmacy - Some programs deliver directly to your doctor's office - Ask about expedited delivery if urgent ## What If You're Denied Assistance? If you don't qualify for one program: - Apply to other assistance programs (eligibility varies) - Ask your doctor about lower-cost alternatives - Inquire about extended payment plans with the pharmacy - Contact the manufacturer directly to ask about future program development - Work with an ALS organization that may provide grants ## Important Insurance Information **Medicare Part D Coverage:** - RELYVRIO may be covered, but check your specific plan - You may have copayments or need prior authorization - Contact your plan or call Medicare at 1-800-MEDICARE **Medicaid:** - Coverage varies significantly by state - Contact your state Medicaid office - Some states have special ALS programs **Commercial Insurance:** - Most plans cover ALS medications - Ask about your specific coverage and costs - Request appeals if the drug is denied ## Reauthorization and Ongoing Support - Assistance programs typically provide coverage for one year - You may need to reapply annually - Keep your application materials organized - Contact programs 30-60 days before your assistance expires - Stay in touch with patient organizations for ongoing support ## Legal Disclaimer This guide is for informational purposes only and is not medical advice. Program availability, eligibility requirements, and benefits change frequently. Always verify current information directly with programs and your healthcare provider. This guide does not constitute a guarantee of assistance or coverage. Consult with your healthcare provider regarding your medical care and medication needs. ## Questions? **ALS Association:** 1-800-782-4747 **Medicare:** 1-800-MEDICARE (1-800-633-4227) **Your State Medicaid Office:** Search online for your state's program **Your Healthcare Provider:** Ask about social work or financial counseling services Remember: You have options for accessing RELYVRIO. Don't give up—reach out to multiple resources and ask for help navigating the system.

Program information last verified: March 25, 2026