PYRUKYND

PYRUKYND Patient Assistance Program Guide: How to Get Mitapivat at Low or No Cost

About This Guide

If you've been prescribed PYRUKYND (mitapivat) to treat pyruvate kinase (PK) deficiency but are concerned about the cost, you're not alone. This guide explains how Agios Pharmaceuticals' Patient Assistance Program (PAP) can help you access PYRUKYND at little to no cost if you qualify.

What Is PYRUKYND?

PYRUKYND (mitapivat) is a prescription medication that activates pyruvate kinase, an enzyme deficient in patients with PK deficiency. This rare genetic blood disorder affects how red blood cells function and can cause anemia, fatigue, and other complications. PYRUKYND helps activate the remaining pyruvate kinase in your body, improving red blood cell survival and reducing anemia symptoms.

About the Agios Patient Assistance Program

Agios Pharmaceuticals offers a Patient Assistance Program (PAP) to help uninsured and underinsured patients afford PYRUKYND. Through this program, eligible patients may receive their medication at reduced cost or free of charge, depending on their financial situation.

Who Qualifies?

You may qualify for the Agios PAP if you meet these criteria:

Insurance Status:

• You are uninsured, OR
• You are underinsured (your insurance doesn't cover PYRUKYND or your out-of-pocket costs are too high)
• Note: Patients with government insurance (Medicare, Medicaid) are generally not eligible for this PAP but may qualify for other support programs

Other Requirements:

• You have a valid prescription for PYRUKYND from your doctor
• You meet the income requirements (see table below)
• You are a U.S. resident

Income Eligibility

Income limits for the PAP vary based on your household size. Contact the program directly at (877) 772-4467 for the most current income thresholds, as limits may change. Generally, the program serves patients with incomes up to 400-500% of the federal poverty level, but exact limits depend on individual circumstances.

What counts as income:

• Wages and salaries
• Self-employment income
• Social Security benefits
• Disability payments
• Pension and retirement income
• Child support or alimony
• Investment income

How to Apply: Step-by-Step Instructions

Step 1: Gather Required Documents

Before you call, have the following ready:

• Your current prescription for PYRUKYND (ask your doctor's office to provide this)
• Proof of income (recent pay stubs, tax returns, Social Security award letter, or benefits statement)
• Proof of U.S. residency (driver's license, state ID, or utility bill)
• Your insurance information (if applicable) or proof of being uninsured
• Your contact information and preferred pharmacy

Step 2: Call the PAP Program

Contact the Agios Patient Assistance Program by phone:

Phone: (877) 772-4467

A program representative will:

• Answer your questions about eligibility
• Walk you through the application process
• Help you submit required documents
• Explain what happens next

Tip: Call during business hours (typically Monday-Friday, 9 AM-5 PM EST). Have all documents available during your call.

Step 3: Submit Documentation

During your phone call, the program representative will explain how to submit:

• Income verification documents
• Your prescription
• Any other required paperwork

Documents may be submitted by phone, fax, mail, or online, depending on the program's current process. Ask the representative which method is fastest.

Step 4: Wait for Approval

The typical processing time is 4-8 weeks. The program will contact you by phone or mail once a decision is made. If approved, they'll explain your benefit level and next steps.

Step 5: Receive Your Medication

Once approved, PYRUKYND will be shipped to you through an exclusive specialty pharmacy. This pharmacy specializes in distributing expensive or complex medications and will handle shipping directly to your home or your doctor's office, depending on what works best for you.

What to Expect Timeline-Wise

Important Notes About Insurance and Government Programs

Medicare/Medicaid Patients: If you have Medicare or Medicaid, you are generally not eligible for this manufacturer PAP. However, you may qualify for other assistance programs:

• Contact your state Medicaid program about coverage
• Ask your doctor about patient support services
• Check www.needymeds.org for additional resources
• Your pharmacy may have other discount programs available

Underinsured Patients: If your insurance has high deductibles or doesn't cover PYRUKYND, the PAP may still help. Contact the program to discuss your situation.

Savings Card Option

In addition to the PAP, Agios offers a savings card that may reduce your out-of-pocket costs if you have commercial insurance. Check the manufacturer website at www.pyrukynd.com for details and eligibility.

What If Your Application Is Denied?

If you don't qualify for the PAP, you have other options:

1. Appeal: Ask if you can provide additional information or updated income documentation
2. Savings Card: Apply for the manufacturer's savings card if you have commercial insurance
3. Patient Advocacy Organizations: Contact PK Deficiency support groups for additional resources
4. Hospital Financial Assistance: Your hospital or treatment center may have financial aid programs
5. State Programs: Your state may have pharmaceutical assistance programs
6. NeedyMeds.org: Search this database for additional local and national programs

Reauthorization and Refills

Once approved, clarify with the program:

• How often you need to reapply or reauthorize
• How your ongoing prescriptions will be handled
• How to request refills
• Who to contact with questions about your benefits

Questions? Contact the Program

Agios Patient Assistance Program Phone: (877) 772-4467

Program staff are available to answer questions about:

• Eligibility requirements
• Application status
• Medication access
• Financial assistance options

Legal Disclaimer

This guide is for informational purposes only and is not a substitute for professional medical or legal advice. Eligibility requirements, income thresholds, and program details may change without notice. For the most current information, always contact the Agios Patient Assistance Program directly at (877) 772-4467 or visit www.pyrukynd.com. Your healthcare provider and the PAP program are your best resources for understanding your specific situation and options.