Pemazyre

IncyteCARES Patient Assistance Program Guide: How to Get Pemazyre (pemigatinib) at Low or No Cost

Pemazyre (pemigatinib) is a targeted oral therapy used to treat certain advanced cancers, and the IncyteCARES Patient Assistance Program from Incyte Corporation helps eligible patients access it at little or no cost if they face financial hardship.

About Pemazyre (pemigatinib)

Pemazyre is a prescription medication that targets specific genetic changes in cancer cells. It is FDA-approved for two main uses:

• Adults with previously treated, unresectable locally advanced or metastatic cholangiocarcinoma (a type of bile duct cancer) that has a fibroblast growth factor receptor 2 (FGFR2) fusion or other rearrangement. This means the cancer has progressed after at least one prior systemic therapy, and genetic testing confirms the FGFR2 alteration.[1][3]
• Adults with relapsed or refractory myeloid/lymphoid neoplasms (MLNs) with a fibroblast growth factor receptor 1 (FGFR1) rearrangement.[2]

Pemazyre works by blocking FGFR proteins, which can fuel cancer growth in these genetically defined tumors. It is taken as a tablet: 13.5 mg orally once daily on a continuous basis until disease progression or unacceptable side effects occur.[2] Common side effects include fatigue, diarrhea, dry mouth, nail toxicity, and eye problems like retinal pigment epithelial detachment (RPED). Your doctor will monitor you closely, especially for eye issues.[4]

This drug is often used when surgery isn't possible and prior treatments have failed. Genetic testing (like FGFR testing) is essential to confirm eligibility.[1][3]

Who Qualifies for the Program?

The IncyteCARES program assists US patients who:

• Have a valid prescription for Pemazyre.
• Are 18 years or older.
• Live in the United States (including territories).
• Demonstrate financial need, typically based on household income at or below 400-500% of the Federal Poverty Level (FPL), though exact thresholds vary and are not publicly detailed without application.
• Lack adequate insurance coverage or face high out-of-pocket costs.

Patients with Medicare, Medicaid, or other government insurance may still qualify for copay assistance or free medication bridges, but free drug eligibility often excludes those with government coverage.[1][2]

Income Eligibility Breakdown

IncyteCARES evaluates income holistically, considering household size, expenses, and assets. While specific thresholds aren't listed publicly, patient assistance programs like this commonly use FPL guidelines. Here's a general table based on 2026 US FPL (approximate; confirm with program for exacts):

Add ~$21,440 per person at 400% FPL for larger families.

Notes: Income includes wages, Social Security, etc. Deductions for medical expenses, housing, or debts may apply. Contact the program for a pre-screen.[1]

Insurance Requirements

• Private Insurance: Eligible for copay cards reducing costs to $0-$10/month (up to $15,000/year benefit).
• Medicare Part D: Copay assistance available, but not for true free drug PAP.
• Uninsured/Underinsured: Qualify for free medication if income-eligible.
• Medicaid: Typically ineligible for free drug but may get bridge supplies.

Your doctor or specialty pharmacy verifies insurance first.[2][3]

Step-by-Step Application Process

1. Discuss with Your Doctor: Confirm Pemazyre is appropriate and request a prescription. Ask them to complete the IncyteCARES enrollment form.

2. Gather Documents:

   • Proof of income (tax returns, pay stubs, W-2s for last 1-2 years).
   • Proof of residency (utility bill, lease).
   • Insurance card or denial letter.
   • Prescription and doctor's notes on diagnosis/FGFR status.

3. Apply Online or by Phone:

   • Visit incytecares.com or call 1-855-426-2983 (IncyteCARES line).
   • Download forms from the patient portal.
   • Specialty pharmacy (e.g., Accredo or Biologics) often handles enrollment.

4. Submit: Doctor faxes signed form; patient uploads docs online.

5. Approval Notification: Via phone/email within days.[1][2]

Timeline and Delivery

• Processing: 1-5 business days for copay; 1-2 weeks for PAP.
• Delivery: Shipped free to your home or doctor's office via specialty pharmacy.
• Supply: 1-3 months initially; auto-refills if eligible.[3]

Alternatives if Denied or Ineligible

• Copay Savings Cards: Even if PAP denies, check IncyteCARES copay program.
• Other PAPs: PAN Foundation, HealthWell Foundation (cancer-specific grants).
• Manufacturer Bridge: Short-term free supply from Incyte.
• Generic/Biosimilars: None available for Pemazyre.[ ]
• Clinical Trials: Search clinicaltrials.gov for FGFR inhibitors.
• State Programs: Check for cancer drug assistance in your state.

Appeal denials with additional docs.[1]

Disclaimer

This guide is for informational purposes only and not medical/financial advice. Eligibility, terms, and thresholds change; contact IncyteCARES directly for current details. Consult your healthcare provider before starting Pemazyre. Program availability as of general knowledge; Incyte reserves rights to modify.[1][2][3]