Pemazyre

Indicated For

cholangiocarcinoma

About This Medication

# IncyteCARES Patient Assistance Program Guide: How to Get Pemazyre (pemigatinib) at Low or No Cost Pemazyre (pemigatinib) is a targeted oral therapy used to treat certain advanced cancers, and the **IncyteCARES Patient Assistance Program** from Incyte Corporation helps eligible patients access it at little or no cost if they face financial hardship. ## About Pemazyre (pemigatinib) **Pemazyre** is a prescription medication that targets specific genetic changes in cancer cells. It is FDA-approved for two main uses: - Adults with **previously treated, unresectable locally advanced or metastatic cholangiocarcinoma** (a type of bile duct cancer) that has a **fibroblast growth factor receptor 2 (FGFR2) fusion or other rearrangement**. This means the cancer has progressed after at least one prior systemic therapy, and genetic testing confirms the FGFR2 alteration.[1][3] - Adults with **relapsed or refractory myeloid/lymphoid neoplasms (MLNs)** with a **fibroblast growth factor receptor 1 (FGFR1) rearrangement**.[2] Pemazyre works by blocking FGFR proteins, which can fuel cancer growth in these genetically defined tumors. It is taken as a tablet: **13.5 mg orally once daily** on a continuous basis until disease progression or unacceptable side effects occur.[2] Common side effects include fatigue, diarrhea, dry mouth, nail toxicity, and eye problems like retinal pigment epithelial detachment (RPED). Your doctor will monitor you closely, especially for eye issues.[4] This drug is often used when surgery isn't possible and prior treatments have failed. Genetic testing (like FGFR testing) is essential to confirm eligibility.[1][3] ## Who Qualifies for the Program? The **IncyteCARES** program assists US patients who: - Have a valid prescription for Pemazyre. - Are **18 years or older**. - Live in the **United States** (including territories). - Demonstrate **financial need**, typically based on household income at or below **400-500% of the Federal Poverty Level (FPL)**, though exact thresholds vary and are not publicly detailed without application. - Lack adequate insurance coverage or face high out-of-pocket costs. Patients with **Medicare, Medicaid, or other government insurance** may still qualify for copay assistance or free medication bridges, but free drug eligibility often excludes those with government coverage.[1][2] ## Income Eligibility Breakdown IncyteCARES evaluates income holistically, considering household size, expenses, and assets. While specific thresholds aren't listed publicly, patient assistance programs like this commonly use FPL guidelines. Here's a general table based on 2026 US FPL (approximate; confirm with program for exacts): | Household Size | 400% FPL (Annual Income) | 500% FPL (Annual Income) | |----------------|---------------------------|---------------------------| | 1 (Individual) | $60,320 | $75,400 | | 2 (Couple) | $81,760 | $102,200 | | 3 | $103,200 | $129,000 | | 4 | $124,640 | $155,800 | *Add ~$21,440 per person at 400% FPL for larger families.* **Notes**: Income includes wages, Social Security, etc. Deductions for medical expenses, housing, or debts may apply. Contact the program for a pre-screen.[1] ## Insurance Requirements - **Private Insurance**: Eligible for copay cards reducing costs to $0-$10/month (up to $15,000/year benefit). - **Medicare Part D**: Copay assistance available, but not for true free drug PAP. - **Uninsured/Underinsured**: Qualify for free medication if income-eligible. - **Medicaid**: Typically ineligible for free drug but may get bridge supplies. Your doctor or specialty pharmacy verifies insurance first.[2][3] ## Step-by-Step Application Process 1. **Discuss with Your Doctor**: Confirm Pemazyre is appropriate and request a prescription. Ask them to complete the IncyteCARES enrollment form. 2. **Gather Documents**: - Proof of income (tax returns, pay stubs, W-2s for last 1-2 years). - Proof of residency (utility bill, lease). - Insurance card or denial letter. - Prescription and doctor's notes on diagnosis/FGFR status. 3. **Apply Online or by Phone**: - Visit **incytecares.com** or call **1-855-426-2983** (IncyteCARES line). - Download forms from the patient portal. - Specialty pharmacy (e.g., Accredo or Biologics) often handles enrollment. 4. **Submit**: Doctor faxes signed form; patient uploads docs online. 5. **Approval Notification**: Via phone/email within days.[1][2] ## Timeline and Delivery - **Processing**: 1-5 business days for copay; 1-2 weeks for PAP. - **Delivery**: Shipped free to your home or doctor's office via specialty pharmacy. - **Supply**: 1-3 months initially; auto-refills if eligible.[3] ## Alternatives if Denied or Ineligible - **Copay Savings Cards**: Even if PAP denies, check IncyteCARES copay program. - **Other PAPs**: PAN Foundation, HealthWell Foundation (cancer-specific grants). - **Manufacturer Bridge**: Short-term free supply from Incyte. - **Generic/Biosimilars**: None available for Pemazyre.[ ] - **Clinical Trials**: Search clinicaltrials.gov for FGFR inhibitors. - **State Programs**: Check for cancer drug assistance in your state. Appeal denials with additional docs.[1] ## Disclaimer This guide is for informational purposes only and not medical/financial advice. Eligibility, terms, and thresholds change; contact IncyteCARES directly for current details. Consult your healthcare provider before starting Pemazyre. Program availability as of general knowledge; Incyte reserves rights to modify.[1][2][3]

Program information last verified: March 30, 2026