Onpattro

Indicated For

polyneuropathy of hereditary transthyretin-mediated (hATTR) amyloidosis

About This Medication

# Alnylam Assist Patient Guide: How to Get Onpattro at Low or No Cost ## About This Program The **Alnylam Assist Patient Assistance Program (PAP)** helps patients who cannot afford Onpattro (patisiran) get access to this life-changing medication at reduced or no cost. Onpattro is an FDA-approved treatment for polyneuropathy caused by hereditary transthyretin-mediated (hATTR) amyloidosis, a rare genetic disorder affecting the nerves and other organs. If you have been prescribed Onpattro and worry about the cost, this guide will help you understand how to apply for financial assistance. ## What Is Onpattro? Onpattro is an innovative RNA interference (RNAi) therapy that works by silencing the gene responsible for producing abnormal transthyretin protein. This protein builds up in the body and damages nerves and organs in hATTR amyloidosis. By reducing this protein, Onpattro can help slow or improve nerve damage and improve quality of life. This is a specialty medication delivered by infusion, typically at a clinic or at home through a specialty pharmacy. ## Who Can Apply? You may qualify for the Alnylam Assist program if you: - Have been prescribed Onpattro by your doctor - Are a U.S. resident - Meet the income eligibility requirements (see table below) - Are **uninsured**, or - Have insurance but face gaps in coverage (delays, denials, or temporary coverage lapses) ### Income Eligibility Guidelines The following table shows approximate maximum household income limits for eligibility. These thresholds are based on federal poverty guidelines and may vary. Contact Alnylam Assist directly to confirm your exact eligibility. | Household Size | Maximum Income (approx.) | |---|---| | 1 person | Varies by state | | 2 people | Varies by state | | 3 people | Varies by state | | 4 people | Varies by state | | 5 people | Varies by state | | 6+ people | Contact program | **Note:** Income limits vary based on state of residence. The program also considers medical expenses, debt, and other financial hardships. Even if your income exceeds these guidelines, you may still qualify based on medical necessity. ## Insurance Requirements The Alnylam Assist program serves two main groups: 1. **Uninsured Patients:** If you have no health insurance and cannot afford Onpattro, you can apply directly to the PAP. 2. **Insured Patients with Coverage Gaps:** If you have insurance but face: - Claim denials - Prior authorization delays - Temporary coverage changes - High copays or deductibles The **Alnylam Assist Bridge Program** may help you bridge the gap while your insurance claim is being processed or resolved. ## How to Apply: Step-by-Step Instructions ### Step 1: Gather Required Documents Before you apply, collect the following: - Your **Alnylam Assist Start Form** (provided by your doctor's office or available from the program website) - Proof of income (recent pay stubs, tax return, or benefit statements) - Proof of residency (utility bill or lease) - Insurance card (if insured) - Photo ID - Current medication list - Your doctor's prescription for Onpattro ### Step 2: Complete the Application You can apply using **multiple methods**: - **Online:** Visit https://www.alnylamassist.com/onpattro/financial-assistance and complete the application through the secure portal - **By Mail:** Print the Alnylam Assist Start Form and mail it with supporting documents to the address listed on the form - **By Phone or Email:** Contact the program through their website for assistance ### Step 3: Submit Your Application Ensure all required documents are included with your completed application. Incomplete applications may delay processing. ### Step 4: Wait for Approval Once submitted, the program typically reviews your application within **4-8 weeks**. You will be notified of the decision by mail or phone. ### Step 5: Receive Your Medication If approved, Onpattro will be shipped directly to your infusion clinic or home address through a specialty pharmacy network (such as US Bioservices). Your doctor and pharmacy will coordinate your infusion schedule. ## Copay Assistance: Alnylam Assist Copay Program Even if you have insurance, you may qualify for the **Alnylam Assist Copay Program**, which helps reduce your out-of-pocket costs. You can self-enroll on the program website. This is separate from the full PAP and may provide immediate assistance while you wait for a full PAP decision. ## Timeline and Delivery - **Application Processing:** 4-8 weeks typical - **Delivery Method:** Shipped via specialty pharmacy to your infusion center or home - **Treatment Schedule:** Your doctor will establish an infusion schedule (typically monthly) ## What If Your Application Is Denied? If you are denied, you have options: 1. **Ask Why:** Request a written explanation of the denial 2. **Appeal:** Many denials can be appealed with additional information or changed circumstances 3. **Reapply:** If your financial situation improves or changes, you may reapply 4. **Seek Help:** Contact your healthcare provider, social worker, or a patient advocacy organization for support ## Other Financial Resources If you do not qualify for the Alnylam Assist PAP or need additional help, consider: - **State Pharmaceutical Assistance Programs:** Many states offer their own assistance programs - **Patient Advocacy Organizations:** Organizations focused on amyloidosis or rare diseases may offer grants or resources - **Clinical Trials:** Ask your doctor if you qualify for clinical trials, which provide free medication - **Hospital Financial Assistance:** Your treatment center may have additional programs ## Privacy and Confidentiality All information you provide to Alnylam Assist is kept confidential and protected under privacy laws. Your medical and financial information will not be shared with outside parties without your consent. ## Important Legal Disclaimer This guide provides general information about the Alnylam Assist Patient Assistance Program. Program eligibility, requirements, and benefits are subject to change. This information is not a guarantee of approval or assistance. For the most current and accurate information, visit https://www.alnylamassist.com/onpattro/financial-assistance or contact the program directly. Always consult with your healthcare provider and the PAP administrator regarding your specific situation. ## Next Steps 1. Talk to your doctor or nurse about your financial concerns 2. Ask your healthcare team for the Alnylam Assist Start Form 3. Visit https://www.alnylamassist.com/onpattro/financial-assistance to learn more 4. Begin gathering required documents 5. Submit your application 6. Follow up on your application status You don't have to navigate this alone. Your healthcare team, the Alnylam Assist program, and patient advocates are here to help.

Program information last verified: March 25, 2026