ONPATTRO

Indicated For

hATTR amyloidosis

About This Medication

# Alnylam Assist Patient Assistance Program (PAP) Patient Guide: How to Get ONPATTRO (patisiran) at Low or No Cost This guide explains the **Alnylam Assist Patient Assistance Program (PAP)** from Alnylam Pharmaceuticals, which provides **ONPATTRO (patisiran)** at no cost to eligible uninsured or underinsured patients. It covers eligibility, application steps, and support options in simple terms to help you access this important treatment for hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis with polyneuropathy). ## About ONPATTRO (patisiran) **ONPATTRO (patisiran)** is an intravenous infusion medication used to treat polyneuropathy (nerve damage) in adults with hereditary transthyretin-mediated (hATTR) amyloidosis. This rare genetic condition causes abnormal protein buildup that damages nerves, heart, and other organs, leading to symptoms like numbness, weakness, pain, and mobility issues. ONPATTRO works by reducing the production of faulty transthyretin (TTR) protein through RNA interference (RNAi) technology, helping slow disease progression, improve quality of life, and preserve motor function in early to mid-stage disease (stages 1 or 2).[9][1] ONPATTRO is given every 3 weeks (0.3 mg per kg of body weight for most patients; 30 mg fixed dose for those 100 kg or more) by a healthcare professional in a clinic or outpatient setting, as it's billed under Medicare Part B or medical benefits.[9] Without assistance, costs can exceed $450,000 annually, making programs like Alnylam Assist PAP essential for many patients.[5] ## Who Qualifies for the Program? The **Alnylam Assist PAP** is designed for patients who cannot afford ONPATTRO due to financial or insurance barriers. Primarily for uninsured patients, it also helps certain underinsured individuals. Key requirements include: - U.S. residency and age 18 or older.[4][9] - Diagnosis of hATTR amyloidosis with polyneuropathy, confirmed by genetic testing for TTR mutation.[9] - Meeting income limits (detailed below). - Uninsured, functionally uninsured, or meeting specific underinsured criteria.[1][2][5] **Income Eligibility Breakdown** Income limits are based on household size and federal poverty level (FPL) guidelines, though exact FPL percentage isn't specified. The program uses a strict cap for individuals. | Household Size | Annual Income Limit | Notes | |---------------|---------------------|-------| | **Individual** | **$75,300** | Primary threshold; higher for larger households (contact program for details) |[5] | Couple | Contact program | May qualify if underinsured or meeting criteria | | Family of 3 | Contact program | Assessed case-by-case | | Family of 4+ | Contact program | Scaled by FPL; proof required |[5] *Notes: Medicare Part B/D patients may qualify; private insurance covering <50% of costs allows underinsured status. Full Medicaid often disqualifies.*[5] ## Insurance Requirements Insurance status is crucial: - **Uninsured**: Primary qualifiers; get ONPATTRO free if income-eligible.[1][2][7] - **Medicare Part B or D**: Eligible—unlike many programs, Alnylam reviews these cases (Part B covers infusions).[5][6] - **Private insurance**: Qualify as underinsured if it covers <50% of costs.[5] - **Medicaid**: Full coverage usually disqualifies; partial may allow bridge help.[5] - **Functionally uninsured**: Denied coverage or high out-of-pocket qualifies.[7] An Alnylam Case Manager assesses after Start Form submission.[1][2] ## Step-by-Step Application Process Applying is straightforward with your doctor's help. Multiple methods available.[5] 1. **Talk to your doctor**: They complete clinical sections of the **Patient Start Form** (download from Alnylam Assist site or request via case manager).[1][3][5] 2. **Gather documents**: - Signed Patient Start Form (patient + prescriber).[5] - Proof of income (tax return, W-2, pay stubs).[5] - Insurance info (cards, denial letters if applicable).[5] - Valid ONPATTRO prescription.[5] 3. **Submit**: Doctor faxes to (833) 256-2747 or uses online portal/HCP tools. Case Manager proactively reviews.[1][2][5] 4. **Follow up**: Expect contact from Case Manager for questions.[1] ## Timeline and Delivery - **Processing**: 7-10 business days after complete submission.[5] - **Delivery**: Shipped free to your prescriber's office or infusion center—not directly to home.[5] - **Start treatment**: Once approved, infusions begin promptly. ## If Denied or Need Alternatives - **Appeal**: Contact Case Manager for review; provide more docs.[1] - **Bridge Program**: Free meds during coverage delays/changes.[2] - **Copay Program**: For commercial insurance; auto-enrolls or self-enroll online.[1][2] - **Independent foundations**: Dashboards on Alnylam site list 501(c)(3) options for uninsured/underinsured.[1][2] - **Other Alnylam programs**: Check for ONPATTRO-specific support.[8] - No biosimilars available currently.[] ## Important Disclaimer This guide is for informational purposes based on available program details as of 2026. Eligibility, terms, and income limits can change—always verify with Alnylam Assist (contact via Start Form or HCP site). Not medical/financial advice; consult your doctor and advisor. Alnylam not liable for application outcomes. Program may exclude certain states or have other restrictions.[1][5]

Program information last verified: March 30, 2026