Nuplazid

Indicated For

hallucinations and delusions associated with Parkinson's disease psychosis

About This Medication

# Acadia Connect Patient Guide: How to Get Nuplazid at Low or No Cost Nuplazid (pimavanserin) is a prescription medication approved to treat **hallucinations and delusions** associated with **Parkinson’s disease psychosis (PDP)**. The **Acadia Connect** program from Acadia Pharmaceuticals Inc. helps eligible patients access Nuplazid through financial assistance, co-pay support, and free medication options, potentially at $0 cost. ## About Nuplazid Nuplazid comes as **34 mg capsules** (standard dose) or **10 mg tablets** (for certain drug interactions). The recommended dose is **one 34 mg capsule taken orally once daily**, with or without food, without needing titration. It targets symptoms like hallucinations and delusions in PDP patients. **Important safety notes** include a **Boxed Warning** for increased mortality risk in elderly patients with dementia-related psychosis (Nuplazid is not approved for dementia psychosis unless linked to Parkinson’s). It can prolong the **QT interval**, so avoid if you have heart rhythm issues, certain medications, or risk factors like low potassium. Common side effects (≥2% more than placebo) are **peripheral edema (7%)**, **nausea (7%)**, **confusional state (6%)**, **hallucinations (5%)**, **constipation (4%)**, and **gait disturbance (2%)**. Contraindicated in hypersensitivity to pimavanserin. Drug interactions: Reduce dose to 10 mg with strong CYP3A4 inhibitors; avoid strong/moderate CYP3A4 inducers.[1][2][3] Always discuss with your doctor if Nuplazid fits your condition, as confirmation of PDP diagnosis is required. ## Who Qualifies for Acadia Connect? Acadia Connect offers support for **commercially insured**, **Medicare Part D**, **Medicaid**, **underinsured**, and **uninsured** patients. **Commercially insured patients** may get **$0 co-pay**. A **free 14-day supply** (with 1 refill) is available via RareMed Pharmacy for PDP patients, limited to facilities accepting free product. Financial assistance is available, but **specific income thresholds are not publicly detailed**—terms and conditions apply. Eligibility focuses on diagnosis, insurance status, and financial need, determined case-by-case. Your doctor must confirm PDP and provide a prescription.[1] ## Income Eligibility Breakdown Public details on exact income limits (e.g., Federal Poverty Level percentages) are unavailable, as Acadia does not publish them. Assistance is tailored; contact the program for personalized review. | Household Size | Income Threshold | Notes | |---------------|------------------|-------| | Individual | Not specified | Financial need assessed individually; terms apply. | | Couple | Not specified | Contact program for details. | | Family of 3 | Not specified | Eligibility not detailed publicly. | | Family of 4 | Not specified | Varies by insurance and situation. | Call **(844) 737-2223** or visit the enrollment page to check eligibility.[1] ## Insurance Requirements The program supports various coverages: - **Commercial insurance**: $0 co-pay for qualifying patients. - **Medicare Part D**: Reimbursement and coverage assistance. - **Medicaid**: Support available. - **Underinsured/uninsured**: Free or reduced-cost options, like the 14-day supply. Provide insurance details (e.g., plan number, group number, Medicare ID) on the form. Acadia verifies benefits and helps secure coverage. Patient authorization allows sharing PHI for reimbursement, co-pay help, and free product.[1][2] ## Step-by-Step Application Process 1. **Talk to your doctor**: Get a prescription for Nuplazid (34 mg capsule, 30-day supply or 14-day free trial). Confirm PDP diagnosis. 2. **Gather documents**: Need **Treatment & Service Request Form** and **Letter of Medical Necessity** from your prescriber. 3. **Submit application** (multiple methods): - **Online**: acadiaconnect.com/nuplazid/healthcare-providers/enrollment - **Phone**: (844) 737-2223 - **Fax**: 1-844-737-2224 - **Email**: acadiaconnect@acadia-pharm.com (note: may not be encrypted) 4. **Prescriber completes form**: Includes NPI, signature, patient info (DOB, address, insurance), sig (e.g., 34 mg once daily), refills, pharmacy preference (e.g., RareMed), allergies. 5. **Authorize sharing**: Sign to allow Acadia to handle PHI, benefits verification, and pharmacy transmission. 6. **Wait for approval**: Program reviews and coordinates with RareMed Pharmacy. Applications are processed quickly, though exact timelines vary.[1] ## Timeline and Delivery Processing time not specified publicly—call for updates. Once approved, Nuplazid ships **via specialty pharmacy like RareMed Pharmacy** directly to your home, assisted living, skilled nursing facility, or preferred location. E-prescriptions go to RareMed. Free 14-day supply (34 mg capsules) limited for PDP; full supplies for eligible patients. Refills require **reauthorization**.[1] ## Alternatives if Denied - **Appeal**: Contact Acadia Connect at (844) 737-2223 with additional info. - **Other assistance**: Check PAN Foundation, NeedyMeds, or Partnership for Prescription Assistance for PDP meds. - **Patient Access Network (PAN)**: May cover gaps for Parkinson’s treatments. - **Generic/biosimilars**: None available for pimavanserin. - **Discuss with doctor**: Dose adjustments, trials, or other PDP therapies (e.g., quetiapine off-label, but with risks). No biosimilar alternatives listed.[1] ## Reauthorization and Refills **Reauthorization is required**. For renewals, use nuplazidcopay.com/renew-info-search or resubmit forms. Prescriber may e-prescribe refills to RareMed. Track via Acadia Connect portal.[1][2] ## Disclaimer This guide is for informational purposes based on publicly available program details as of latest updates. Eligibility, benefits, and terms can change—**always verify with Acadia Connect at (844) 737-2223 or acadiaconnect.com**. Not medical advice; consult your healthcare provider. Acadia may contact you for more info. PHI shared per authorization for program support only. Read full Prescribing Information, including Boxed Warning, at NUPLAZIDhcp.com. Word count: 1028.

Program information last verified: March 25, 2026