Nexviazyme

Indicated For

late-onset Pompe disease

About This Medication

# CareConnect Patient Support Services Patient Guide: How to Get Nexviazyme (avalglucosidase alfa-ngpt) at Low or No Cost Nexviazyme (avalglucosidase alfa-ngpt) is an enzyme replacement therapy used to treat Pompe disease, a rare genetic disorder that causes muscle weakness and breathing problems due to a deficiency in the enzyme acid alpha-glucosidase. **CareConnect Patient Support Services**, sponsored by **Sanofi**, offers the Patient Assistance Program to provide Nexviazyme at no cost to eligible uninsured patients or those unable to access it through their insurance.[5] This guide explains eligibility, application steps, and support options in simple terms to help you get started on your treatment journey. ## About Nexviazyme and Pompe Disease Pompe disease affects about 1 in 40,000 people and can appear in infancy (classic form) or later in life (non-classic form). Symptoms include progressive muscle weakness, fatigue, difficulty breathing, and heart problems in severe cases. **Nexviazyme** replaces the missing enzyme, helping break down glycogen buildup in muscles and improving strength and respiratory function. It's given as an intravenous (IV) infusion every two weeks, typically in a clinic or hospital.[1][5] Clinical studies show it can improve walking distance and lung function compared to other treatments. Always consult your doctor to see if it's right for you. ## Who Qualifies for CareConnect Patient Assistance Program? The program targets patients with rare diseases like Pompe who face barriers to treatment. Key requirements include: - U.S. residency (including territories). - Under the care of a licensed healthcare provider (HCP). - **No health insurance coverage, or unable to access Nexviazyme under your insurance terms** (e.g., denied coverage or non-covered).[5][1] **Income eligibility**: No specific income thresholds or Federal Poverty Level (FPL) limits are listed. Qualification focuses on insurance status rather than finances, making it accessible for uninsured patients regardless of income.[1] This is a temporary bridge until insurance coverage is secured.[5] ### Income Eligibility Breakdown | Household Size | Income Threshold | FPL % | Notes | |---------------|------------------|-------|-------| | Individual | None specified | None | Focus on lack of insurance access[1] | | Couple | None specified | None | No income caps mentioned[1] | | Family of 3 | None specified | None | Insurance status primary criterion[5] | | Family of 4 | None specified | None | Temporary aid until coverage obtained[5] | This table reflects the program's emphasis on insurance gaps over strict income rules, unlike many programs with FPL caps.[1][5] ## Insurance Requirements **You must not have insurance coverage or be unable to obtain Nexviazyme through your plan.** This includes commercial, private, Medicare, or Medicaid patients denied access. Medicare patients are typically ineligible for free drug programs due to federal anti-kickback laws, but call to confirm if your plan denies coverage.[1][2][5] The program verifies this during enrollment. If insured, explore CareConnect's separate **Copay Program** for out-of-pocket costs like deductibles (up to a maximum).[3] ## Step-by-Step Application Process CareConnect offers **multiple application methods** for flexibility. Start by enrolling in CareConnect Personalized Support Services, then apply for assistance.[1][5] 1. **Enroll in CareConnect**: Visit the enrollment page or call **(888) 847-4877** (English: press 3; Spanish: press 7). Available Mon-Fri, 8AM-6PM EST. Select Nexviazyme as your product. Spanish speakers can toggle language online.[1] A dedicated Case Manager will guide you. 2. **Discuss with Your Doctor**: Your HCP must confirm your diagnosis, prescribe Nexviazyme, and complete application sections.[4][7] 3. **Submit Application**: - **Online**: Enroll at careconnectpss.com/enrollment and request Patient Assistance.[1] - **Phone**: Call (888) 847-4877 for help, paper forms, or if not on treatment yet.[1][9] - **Mail/Fax**: Download forms; mail to addresses like Sanofi Patient Connection PO Box 222138, Charlotte, NC 28222-2138 or fax 1-888-847-1797.[4][7] Provide patient details (name, DOB, address, phone), HCP signature, and HIPAA consent.[4] 4. **Case Manager Support**: They'll investigate benefits, explain options, and handle paperwork. No fees to enroll.[1][5] ## Timeline and Delivery Processing takes **5-7 business days** for complete applications; incomplete ones delay due to follow-ups.[7] Your Case Manager contacts you and your doctor within 1-2 business days of enrollment.[10] If approved, **Nexviazyme is shipped at no cost** to your doctor's office, infusion center, or pharmacy for administration. Delivery method isn't specified but coordinated by your team. Refills require reapplication or HCP reauthorization (details below).[4][5] ## Alternatives if Denied or Ineligible - **Copay Program**: For insured patients; covers copays, coinsurance, deductibles up to max. Apply online or call.[3] - **Appeal Denial**: Contact your Case Manager to review insurance denial or resubmit.[1] - **Other Resources**: State programs, nonprofits like Patient Access Network (PAN), or generic/biosimilar options (none currently for Nexviazyme).[1][5] - **Sanofi Patient Connection**: Separate program at (888) 847-4877.[7][9] No biosimilars listed for Nexviazyme.[1] ## Important Disclaimer This guide is for informational purposes based on publicly available program details as of March 2026. **Eligibility, terms, and availability can change.** Contact CareConnect at (888) 847-4877 or your Case Manager for personalized advice. Not legal/medical advice—consult your healthcare provider. Program excludes Medicare/Medicaid typically; federal laws apply. Sanofi reserves rights to modify/amend.[1][4][5][7] (Word count: 1028)

Program information last verified: March 30, 2026