MAYZENT

Indicated For

Relapsing forms of multiple sclerosis (MS), clinically isolated syndrome, relapsing-remitting disease, active secondary progressive disease

About This Medication

# Novartis Patient Assistance Foundation (NPAF) Patient Guide: How to Get MAYZENT (siponimod) at Low or No Cost This guide explains how the **Novartis Patient Assistance Foundation (NPAF)** can help you access **MAYZENT (siponimod)**, a prescription medication used to treat relapsing forms of multiple sclerosis (MS), at little or no cost if you meet eligibility criteria. NPAF provides free medication to eligible patients who lack adequate insurance coverage and have limited income.[1][3][6] ## About MAYZENT (siponimod) **MAYZENT (siponimod)** is an oral medication approved for adults with relapsing-remitting multiple sclerosis (RRMS), active secondary progressive MS (SPMS), and certain other relapsing forms of MS. It works by modulating sphingosine-1-phosphate receptors in the body to reduce inflammation and prevent immune cells from attacking the protective covering of nerves in the brain and spinal cord. Common side effects may include headache, high blood pressure, and increased risk of infections; always consult your healthcare provider (HCP) for personalized advice on its use, dosage, and monitoring needs.[1][5] MAYZENT is typically taken once daily and requires careful starting dose titration to minimize heart-related risks. Your doctor will monitor your heart rate before and during treatment initiation. This program focuses on financial access, not medical advice—discuss MAYZENT's suitability with your HCP.[3] ## Who Qualifies for NPAF? To qualify for free MAYZENT through NPAF, you must meet these key requirements: - **Residency**: Live in the United States or a U.S. territory.[3][6] - **Prescription**: Have a valid prescription for MAYZENT from a licensed U.S. HCP treating you on an outpatient basis.[1][3] - **Insurance Status**: Be uninsured, underinsured, or have government insurance, but **cannot** have private insurance tied to alternate funding programs that base coverage on PAP enrollment. Submit copies of all insurance cards (front and back).[1][2][3] - **Income**: Meet program-specific income guidelines based on **Federal Poverty Level (FPL)**, which vary by household size and medication. Specific thresholds for MAYZENT are not publicly listed; check eligibility at www.PAP.Novartis.com or call 1-800-277-2254.[1][6] NPAF serves patients unable to afford their Novartis medications due to financial hardship. Health plans, specialty pharmacies, or their agents cannot enroll you—only you, your legal guardian, or caregiver may apply.[1][3] ## Income Eligibility Breakdown NPAF uses income guidelines tied to the **Federal Poverty Level (FPL)** on a sliding scale, adjusted for household size (as reported on your tax return). Exact percentages or dollar amounts for MAYZENT are not disclosed publicly and depend on the medication—contact NPAF for your situation.[1][6] Here's a general example of how FPL-based thresholds often work (hypothetical; verify with NPAF for MAYZENT specifics): | Household Size | Example 400% FPL Threshold (2026 est.) | |----------------|---------------------------------------| | 1 (Individual) | ~$60,000 annually | | 2 (Couple) | ~$81,000 annually | | 3 | ~$102,000 annually | | 4 | ~$123,000 annually | **Notes**: Provide proof like the first 2 pages of your most recent 1040 tax return (or 1040EZ), W-2s, 1099s, Social Security statements, or pay stubs if not filing taxes. Guidelines apply but are medication-specific—call 1-800-277-2254 to confirm.[2][6][8] ## Insurance Requirements - **Uninsured or Underinsured**: Ideal candidates have no prescription coverage or limited coverage that doesn't fully cover MAYZENT.[3][6] - **Government Insurance**: Medicare or Medicaid patients may qualify if they meet income rules and provide evidence of Extra Help denial if required.[1][2] - **Private Insurance**: Submit prior authorization (PA) or appeal denial copies if your plan requires them. No coverage from programs conditioning on PAP apps.[1][2] - **All Cases**: Attach front/back copies of **all** insurance cards (primary, secondary, Rx).[2][3] Prohibited: Enrollment by insurers or pharmacies.[1] ## Step-by-Step Application Process 1. **Check Eligibility**: Visit www.PAP.Novartis.com or call **1-800-277-2254** (Mon-Fri, 9 AM-6 PM ET) to confirm MAYZENT qualifies you based on income/residency.[1][3][6] 2. **Download Form**: Get the application from pap.novartis.com (patient and HCP sections).[2][3] 3. **Gather Documents**: - Proof of income (e.g., tax return pages 1-2).[2][6][8] - Insurance cards (front/back).[2][3] - Evidence of Extra Help denial (if needed).[1] - Valid MAYZENT prescription.[3][8] 4. **Complete Sections**: Fill patient info, income, insurance, and sign authorizations. Your HCP completes their section, prescription, and authorization.[2][3][4] 5. **Submit**: Fax to **1-855-817-2711** or mail to NPAF, PO Box 2529, Columbus, OH 43216 (or current address from site).[2][6] **Tip**: Incomplete apps delay or deny processing—double-check everything.[1][2][3] ## Timeline and Delivery Expect a decision letter within **4 weeks** of submission; texts if opted in.[1][6] If approved, medication ships **directly to you** (your home or specified address).[1] Processing may take longer if docs are missing—you'll get a letter with next steps.[1] Refills/reauthorization details not specified; contact NPAF post-approval.[1] ## Alternatives if Denied - **Review Denial Letter**: Follow instructions for resubmission (e.g., missing docs).[1] - **Call NPAF**: 1-800-277-2254 for guidance.[1][6] - **Other Programs**: Check Novartis co-pay assistance (if insured), Simplefill, or RxHope for matches.[5][9] - **Extra Help**: Apply for Medicare Low-Income Subsidy if eligible.[1] - **State Assistance**: Local MS societies or generic options via your HCP.[7] ## Disclaimer This guide is for informational purposes based on available NPAF details as of 2026 and is not medical, legal, or financial advice. Eligibility, guidelines, and processes can change—verify at www.PAP.Novartis.com or 1-800-277-2254. NPAF reserves rights to modify/discontinue. Consult your HCP for treatment; program availability not guaranteed. Word count: ~950.

Program information last verified: March 30, 2026