Lysodren

Indicated For

adrenocortical carcinoma

About This Medication

# Direct Success Patient Assistance Program Guide: How to Get Lysodren (mitotane) at Low or No Cost Lysodren (mitotane) is a prescription medication used to treat adrenocortical carcinoma, a rare cancer of the adrenal glands. The **Direct Success Patient Assistance Program**, offered through **Direct Success** (in partnership with Walgreens Specialty Pharmacy), helps qualifying patients access Lysodren at low or no cost by shipping it directly after phone-based application[1]. ## About Lysodren (mitotane) **Lysodren** is an oral tablet (typically 500mg) specifically approved for treating adrenocortical carcinoma (ACC), a type of cancer affecting the adrenal glands located above the kidneys. It works by destroying cancer cells in the adrenal cortex and suppressing their growth. Unlike chemotherapy, mitotane acts like an adrenal poison, targeting the tumor while requiring careful monitoring due to side effects like nausea, vomiting, diarrhea, and adrenal insufficiency—which means patients often need steroid replacement therapy[4]. Your doctor will prescribe Lysodren if you have advanced or recurrent ACC. Treatment usually starts at low doses (e.g., 2-6 grams per day, divided) and is adjusted based on blood levels (target: 14-20 mcg/mL) to balance effectiveness and toxicity. Regular blood tests are essential, as mitotane affects cholesterol, thyroid, and other hormones. Always follow your healthcare team's guidance, and never stop or change doses without consulting them[4]. This program makes Lysodren more affordable, especially since without assistance, costs can exceed thousands monthly. With commercial insurance, copays are often around **$80/month**; the program provides free or reduced-cost access for those denied coverage or uninsured[1]. ## Who Qualifies? The Direct Success program is designed for **qualifying patients** facing financial hardship, particularly those denied insurance coverage or lacking prescription drug benefits. Specific income thresholds are not publicly listed online—instead, eligibility is determined case-by-case via phone. Factors include household income, family size, insurance status, and medical need[1]. Medicare Part D patients may qualify through a **case-by-case appeals process** if they demonstrate significant financial and medical hardship[1]. Uninsured or underinsured U.S. residents are prioritized. There's no mention of citizenship requirements, but programs like this typically require U.S. residency. ## Income Eligibility Breakdown Detailed income limits (e.g., Federal Poverty Level percentages) are **not specified online** and must be verified by calling (1-844-597-6373). Programs often align with 400-500% of the Federal Poverty Level (FPL). For reference, similar programs use guidelines like: | Household Size | Annual Income Limit (Approximate) | |---------------|----------------------------------| | Individual | Up to $50,000-$60,000 | | Couple | Up to $70,000 | | Family of 3 | Up to $90,000-$100,000 | | Family of 4 | Up to $110,000-$120,000 | *Notes: These are illustrative based on comparable programs; exact thresholds for Direct Success require phone confirmation. Larger families may qualify up to $200,000[2].* ## Insurance Requirements This program is ideal if you've been **denied coverage** or **lack insurance**. Patients with **commercial insurance** typically pay about **$80/month** copay, but the program steps in for those unable to afford it. Medicare Part D enrollees are not automatically excluded—apply via appeals for financial/medical need[1]. Government insurance (Medicaid, etc.) may have restrictions; confirm during application. ## Step-by-Step Application Process 1. **Gather Information**: Have your doctor's prescription, proof of income (e.g., tax returns, pay stubs), insurance denial letter (if applicable), and personal details ready. 2. **Call to Apply**: Dial **(1-844-597-6373)**. A representative will screen eligibility over the phone—no online application or downloadable forms[1]. 3. **Provide Details**: Share income, household size, insurance status, and medical history. Your doctor may need to complete a prescription form or provide clinical notes. 4. **Submit Documents**: Fax, upload, or mail any required paperwork (e.g., income proof, denial letter). Exact documents aren't listed—ask during the call. 5. **Approval Wait**: Processing time varies; similar programs take 2-4 weeks after all info is received[2]. 6. **Receive Medication**: If approved, Lysodren ships **via Walgreens Specialty Pharmacy** directly to you or your doctor. Track refills through them. Call during business hours (typically Mon-Fri, 8 AM-8 PM ET) for fastest service. ## Timeline and Delivery Expect **2-4 weeks** for first delivery after complete paperwork, based on similar programs[2]. Ongoing refills are managed automatically, shipped via **Walgreens Specialty Pharmacy**. Contact them for status updates. Reauthorization may be needed annually or periodically—details provided upon approval. ## Alternatives if Denied - **Prescription Hope**: $60/month flat fee; income up to $50K individual/$70K household. Handles applications for you[2]. - **RxHope/RxAssist**: Additional PAP listings; call 800-861-0048 for Lysodren options[1][5]. - **GoodRx Coupons**: Discount cards for uninsured/low-income[3]. - **Manufacturer Support**: Check lysodren.com for resources[4]. - **State Programs**: Local Medicaid or charity care. If denied, reapply with updated info or try appeals. ## Disclaimer This guide is for informational purposes only and based on available data as of 2026. Program details can change—**always verify by calling (1-844-597-6373)**. Not medical advice; consult your doctor for treatment decisions. Eligibility not guaranteed. Word count: 1028.

Program information last verified: March 30, 2026