LUMRYZ

Indicated For

narcolepsy

About This Medication

# RYZUP Patient Assistance Program Patient Guide: How to Get LUMRYZ at Low or No Cost LUMRYZ (sodium oxybate) is an extended-release oral suspension prescribed for adults and children 7 years and older with narcolepsy to treat excessive daytime sleepiness and cataplexy. The **RYZUP Patient Assistance Program (PAP)** from Avadel provides this medication **free of charge** to eligible uninsured or underinsured patients who meet specific criteria, helping reduce financial barriers to treatment.[1][2] ## About LUMRYZ and Narcolepsy **Narcolepsy** is a chronic neurological disorder that disrupts the brain's ability to regulate sleep-wake cycles, causing uncontrollable daytime sleepiness, sudden muscle weakness (cataplexy), sleep paralysis, and hallucinations. LUMRYZ, taken once nightly, helps improve nighttime sleep consolidation, reducing these symptoms and enhancing daily functioning.[2] **Key facts about LUMRYZ**: - **Once-nightly dosing**: Mix with water and take within a 2-hour window before bedtime; do not eat 2 hours before or after.[2] - **REMS program required**: Due to risks like respiratory depression when combined with CNS depressants (e.g., opioids, alcohol), LUMRYZ is only available through certified pharmacies in the **LUMRYZ REMS** program. Both you and your healthcare provider (HCP) must enroll at LUMRYZREMS.com.[1][2] - **Safety warnings**: Avoid activities requiring alertness (driving, operating machinery) for at least 6 hours after dosing. High sodium content may not suit those on salt-restricted diets, with hypertension, heart failure, or kidney issues.[2] Always follow your doctor's instructions and report side effects like nausea, dizziness, or bedwetting.[2] ## Who Qualifies for RYZUP PAP? The program targets **uninsured or underinsured patients** who lack adequate coverage for LUMRYZ and meet financial need criteria. You must have a valid prescription and be enrolled in LUMRYZ REMS.[1][2] **Eligibility basics**: - Medically necessary LUMRYZ prescribed by an enrolled HCP.[1] - U.S. resident (program administered by Avadel CNS Pharmaceuticals, LLC).[1] - Willing to provide authorization for Avadel to verify income, insurance, and medical info.[1][8] **Income Eligibility Breakdown** Specific income thresholds (e.g., Federal Poverty Level percentages) are **not publicly disclosed**; eligibility is evaluated **case-by-case** upon application review. Submit proof of income to determine qualification—approval is not guaranteed even with a complete application.[1] | Household Size | Estimated Threshold | Notes | |---------------|-------------------|-------| | Individual | Not specified | Case-by-case; typically low-income uninsured/underinsured[1] | | Couple | Not specified | Proof of combined income required[1] | | Family of 3 | Not specified | Household income verification needed[1] | | Family of 4+ | Not specified | Larger families may have adjusted limits; contact program[1] | *Table based on standard PAP structures; exact limits undisclosed. Avadel determines eligibility individually.*[1] ## Insurance Requirements **Uninsured or underinsured** patients qualify—meaning no prescription coverage or coverage insufficient for LUMRYZ (e.g., high copays, denials). Medicare Part D enrollees may qualify, but Avadel will notify CMS and your plan if approved.[1] - **Not for**: Patients with adequate commercial insurance (LUMRYZ covered for >90% of plans).[3] - **Related options**: If insured with delays, check **Temporary Assistance Program (TAP)** for up to 120 days free.[6] Enrollment in **RYZUP Support Services** (via ryzupsupport.iassist.com) connects you to a Nurse Care Navigator (NCN) for insurance navigation.[6][9] ## Step-by-Step Application Process 1. **Enroll in LUMRYZ REMS**: Visit LUMRYZREMS.com or call 1-877-453-1029. Sign Patient Authorization and Enrollment Forms (may be done in HCP office or via email).[1][6] 2. **Discuss with your HCP**: Get a prescription; they must enroll in REMS too.[1] 3. **Start RYZUP Support**: Go to https://ryzupsupport.iassist.com/welcome-patient. Complete: - Patient Authorization for RYZUP Support Services.[7][8] - PAP Application.[1][7] Multiple methods available (online, forms).[1] 4. **Gather Documents**: - **Proof of income** (e.g., tax returns, pay stubs).[1] - **Proof of insurance status** (e.g., denial letter, insurance card showing no coverage).[1] - **Prescription** from HCP.[1] - **Patient authorization** form.[1] 5. **Submit**: Upload via portal or mail. Avadel reviews case-by-case.[1][7] 6. **Contact Support**: Call NCN at 1-844-485-7636 (8 AM-8 PM ET, Mon-Fri) for help.[9] **Pro tip**: Work with your RYZUP NCN—they assist with forms, benefits checks, and submissions.[6][9] ## Timeline and Delivery Processing time varies; submit complete apps for fastest review—no fixed timeline disclosed. If approved, medication ships **directly to your home** via certified specialty pharmacy for the **remainder of the calendar year**.[1] - **Reauthorization required**: Annually or upon changes (e.g., income, insurance).[1] - NCN helps with renewals, refills, and check-ins.[9] Expect NCN outreach post-submission for status updates.[9] ## Alternatives if Denied - **Appeal**: Contact Avadel/NCN to discuss reasons and resubmit updated docs.[1] - **TAP**: Up to 120 days free if insurance delay.[6] - **Other Assistance**: RYZUP NCN explores copay cards, state programs, or generics (none currently).[3][6] - **HCP Support**: Ask about samples or payment plans.[5] - **No biosimilars** available for LUMRYZ.[ ] ## Disclaimer This guide summarizes publicly available info as of latest sources; eligibility/rules may change. **Consult Avadel, your HCP, or NCN for personalized advice**. Submission doesn't guarantee approval—Avadel decides case-by-case. Not legal/medical advice. For full terms, review official forms.[1][2] Always prioritize safety: follow REMS and dosing to avoid serious risks.[2] (Word count: 1028)

Program information last verified: March 30, 2026