Letairis

Indicated For

Pulmonary arterial hypertension (PAH)

About This Medication

# LEAP Patient Support Program Guide: How to Get Letairis at Low or No Cost ## About Letairis (Ambrisentan) Letairis is a prescription medication used to treat pulmonary arterial hypertension (PAH), a serious condition affecting blood vessels in the lungs. The drug helps improve exercise ability and delay disease progression in patients with PAH. Because Letairis carries risks of liver injury and birth defects, it is only available through a restricted distribution program called LEAP (Letairis Education and Access Program).[1][2] ## Who Qualifies for LEAP LEAP is available to **all patients prescribed Letairis**, regardless of insurance status.[2] The program serves two main groups: - **Uninsured or underinsured patients**: May receive Letairis at no cost if they meet needs-based eligibility criteria[6][8] - **Commercially insured patients**: May qualify for copay assistance, paying as little as $5 per month[3][6] - **Medicare Part D beneficiaries**: Can receive support identifying outside resources to help pay copays, coinsurance, and deductibles[6] ### Income Eligibility LEAP uses a needs-based assessment to determine eligibility for free medication. Specific income thresholds are not publicly disclosed; instead, LEAP evaluates your individual financial situation during the application process.[8] When you apply, be prepared to discuss your household income, expenses, and financial hardship. ### Special Requirements for Female Patients All female patients must enroll in the Letairis Risk Evaluation and Mitigation Strategy (REMS) Program before receiving Letairis due to the risk of serious birth defects.[2] This enrollment is separate from the main LEAP application but is required to receive the medication. ## Insurance Requirements | Insurance Type | LEAP Assistance Available | |---|---| | No insurance | Yes—may receive medication free | | Commercial insurance | Yes—copay card available (as low as $5/month) | | Medicare Part D | Yes—help identifying copay/deductible assistance | | Medicaid | No—copay program not available | | TriCare or DoD | No—copay program not available | If your insurance denies coverage, LEAP can help determine why and identify alternative funding sources, including the Patient Assistance Program for free medication.[9] ## How to Apply for LEAP ### Step 1: Get Your Prescription Your healthcare provider must prescribe Letairis and be registered with LEAP to dispense the medication.[10] ### Step 2: Complete Required Forms You and your healthcare provider must complete: - **Letairis Prescription and LEAP Patient Support Enrollment Form**[8] - **Patient Enrollment and Consent Form for the REMS Program** (required for all female patients)[8] These forms are available from your healthcare provider or by calling LEAP.[8] ### Step 3: Submit Your Application Fax completed forms to LEAP: - Main enrollment form: Fax to (888) 882-4035[8] - REMS enrollment form (females only): Fax to (866) 750-9802[8] Alternatively, contact LEAP directly at **(866) 664-5327** for assistance with the application process.[2][6] ### Step 4: Enrollment Confirmation Once approved, you will be enrolled in LEAP and can begin receiving your medication through a Certified Pharmacy.[2] ## Timeline and Medication Delivery LEAP does not publicly disclose specific processing timelines. However, once enrolled, your Certified Pharmacy will coordinate monthly shipments of Letairis to your home.[2] Contact LEAP at (866) 664-5327 to confirm your shipment schedule and address any delivery concerns. ## What Happens If Your Application Is Denied If you are denied coverage, LEAP can: - Explain the reason for denial - Help you understand your insurance benefits and out-of-pocket costs - Identify third-party support resources - Determine if you qualify for the Patient Assistance Program for free medication[9] Contact LEAP immediately if your application is denied to explore alternative options. ## Copay Assistance for Commercially Insured Patients If you have commercial insurance, you may be eligible for the Letairis Co-Pay Coupon Program. Eligible patients are enrolled automatically when prescribed branded Letairis and can pay as little as $5 per month.[6] This program is not available for Medicare, Medicaid, TriCare, or DoD beneficiaries.[3] ## Important Information - LEAP is available only to residents of the US and Puerto Rico[8] - All female patients must complete REMS enrollment before receiving Letairis[2] - Your healthcare provider and pharmacy must be registered with LEAP[10] - LEAP provides ongoing support, including help understanding insurance benefits and coordinating monthly medication shipments[2] ## Contact LEAP **Phone**: (866) 664-5327 (1-866-664-LEAP) **Website**: www.letairisrems.com LEAP representatives can answer questions about eligibility, help with applications, and provide support throughout your treatment. ## Disclaimer This guide provides general information about the LEAP Patient Support Program based on publicly available information as of March 2026. Program details, eligibility criteria, and benefits may change. For the most current and accurate information, contact LEAP directly at (866) 664-5327 or visit www.letairisrems.com. This guide is not a substitute for professional medical or financial advice. Consult your healthcare provider or LEAP representative regarding your specific situation.

Program information last verified: March 30, 2026