Lepodisiran siRNA Lp(a) quarterly SC CV risk

Indicated For

Cardiovascular disease, elevated lipoprotein(a)

About This Medication

# Lilly Cares Patient Guide: How to Get Lepodisiran at Low or No Cost **Important Note:** Lepodisiran is an investigational medication still in clinical trials and not yet FDA-approved as of March 2026. Lilly Cares typically assists with approved Eli Lilly medications, but check www.lillycares.com for updates on availability. This guide assumes potential future eligibility based on Lilly's patient assistance model.[1][3] ## About Lepodisiran Lepodisiran is an experimental **small interfering RNA (siRNA) therapy** developed by Eli Lilly and Company to treat elevated **lipoprotein(a) [Lp(a)]**, a genetically inherited risk factor for heart disease, heart attacks, and strokes. Lp(a) is a type of cholesterol that increases cardiovascular risk, especially in people with high levels (at least 175 nmol/L) who have established heart disease or risk factors like age over 55, narrowed arteries, or familial hypercholesterolemia.[2][4][6] In Phase 2 ALPACA trial results announced in March 2025, lepodisiran reduced Lp(a) levels by up to **93.9%** at the highest dose (400 mg) over 60-180 days, with effects lasting up to 1.5 years in some patients after two doses. It's administered subcutaneously (under the skin), typically twice initially (baseline and day 180). Phase 3 ACCLAIM-Lp(a) trials are ongoing to confirm its ability to reduce major cardiovascular events.[2][5][6][8] **Who might need it?** Adults with high Lp(a) levels, prior heart events (e.g., heart attack, stroke), or multiple risk factors. Always consult your doctor to see if you qualify for trials or future approved use.[4] ## Who Qualifies for Lilly Cares? Lilly Cares Foundation, Inc. is a nonprofit program providing **free Eli Lilly medications for up to 12 months** to U.S. patients (including Puerto Rico and U.S. Virgin Islands) facing financial hardship. Over 20 years, it has helped over 1 million patients.[1][3] Key requirements: - Prescribed qualifying Lilly medication (confirm lepodisiran eligibility directly). - Household income below program guidelines (typically **400% of the Federal Poverty Level (FPL)**, though exact thresholds vary yearly; see table below). - **Not enrolled in government programs** like Medicaid, full Low-Income Subsidy (LIS/Extra Help) for Medicare, or VA benefits.[3] - Permanent U.S. resident. ## Income Eligibility Breakdown Lilly Cares bases eligibility on **household size and income** at or below **400% FPL**. Use the table below for 2026 estimates (FPL updates annually; verify at application). For a household of 1, 400% FPL is about $60,320; add ~$20,000 per additional member. | Household Size | Max Annual Income (400% FPL, approx. 2026) | |----------------|--------------------------------------------| | 1 (Individual) | $60,320 | | 2 (Couple) | $81,760 | | 3 | $103,200 | | 4 | $124,640 | | 5+ | Add ~$21,440 per person | **Notes:** Income includes all household sources. Program may adjust for Alaska/Hawaii. Proof required (tax returns, pay stubs).[3] ## Insurance Requirements You **cannot** be enrolled in: - Medicaid - Full Medicare Extra Help (LIS) - VA Benefits Private insurance, Medicare Part D (without full LIS), or uninsured status is often okay. Lilly Cares may coordinate with your pharmacy/insurer to check coverage. Disclose all insurance for accurate processing.[3] ## Step-by-Step Application Process 1. **Confirm Prescription:** Get lepodisiran prescribed by your doctor. Discuss if it's available via Lilly Cares or trials.[1][3] 2. **Gather Documents:** Prepare proof of income (e.g., last 2 pay stubs, 2025 tax return), residency (ID/utility bill), prescription, and insurance status (card or denial letter).[3] 3. **Apply Online (Recommended):** Visit **www.lillycares.com** for the electronic application—faster and less paperwork. Download PDF if needed.[3] 4. **Phone Option:** Call Lilly Cares (number on site) for assistance.[1] 5. **Submit with Doctor's Help:** Your healthcare provider's office often submits. Include all details on meds, dosage, and need.[3] 6. **Track Status:** Use the patient portal or contact support. Expect notification within weeks.[3] ## Timeline and Delivery - **Processing:** 2-4 weeks typically, longer if docs incomplete.[3] - **Approval:** Free meds shipped for **up to 12 months**.[1] - **Delivery:** Direct to your **pharmacy or home** via mail. Track shipments.[3] - **Refills:** Reapply before 12 months end; reauthorization often needed.[1] ## Alternatives if Denied or Ineligible - **Clinical Trials:** Join Lilly's Phase 3 ACCLAIM-Lp(a) (NCT06292013) for high Lp(a) patients—free drug, monitoring. Search clinicaltrials.gov.[4][6] - **Other Assistance:** NeedyMeds.org, RxAssist.org, or manufacturer copay cards (if approved). - **Medicare Extra Help:** Apply if low-income (partial LIS possible).[3] - **Biosimilars/Generics:** None currently for lepodisiran (investigational).[ ] - **Doctor Samples or Compounding:** Limited for siRNA therapies. ## Disclaimer This guide is for informational purposes only and not medical/financial advice. Eligibility, availability, and rules change—**verify at www.lillycares.com**. Lepodisiran is **not FDA-approved**; assistance unlikely until approval. Consult your healthcare provider. Lilly Cares decisions final; no guarantees. Word count: ~950.

Program information last verified: March 30, 2026