Lamzede

Indicated For

Alpha-mannosidosis (non-central nervous system manifestations)

About This Medication

# Chiesi Total Care Patient Guide: How to Get Lamzede (velmanase alfa-tycv) at Low or No Cost Lamzede (velmanase alfa-tycv) is an enzyme replacement therapy approved by the FDA for treating non-central nervous system manifestations of alpha-mannosidosis, a rare genetic disorder. The **Chiesi Total Care** program from **Chiesi USA Inc.** helps eligible patients access Lamzede through copay assistance, non-financial support, and free medication for those who qualify under the Patient Assistance Program (PAP), making treatment more affordable regardless of insurance status in many cases. ## About Lamzede and Alpha-Mannosidosis **Lamzede** is a recombinant human alpha-mannosidase enzyme administered via intravenous infusion every two weeks. It works by replacing the deficient enzyme in patients with alpha-mannosidosis, helping to reduce the buildup of mannose-containing oligosaccharides in the body. This can improve symptoms like skeletal abnormalities, hearing loss, and mild cognitive issues, though it does not treat central nervous system manifestations. Alpha-mannosidosis is a rare lysosomal storage disorder caused by mutations in the MAN2B1 gene, affecting about 1 in 500,000 people worldwide. Early diagnosis and treatment are crucial for better outcomes. If you or a loved one has been prescribed Lamzede, Chiesi Total Care streamlines access, handling insurance navigation, infusions, and delivery to reduce your burden. ## Who Qualifies for Chiesi Total Care? Chiesi Total Care offers **tiered support** based on your insurance and financial situation: - **Commercial insurance**: Copay assistance can reduce costs to **as little as $0** for eligible patients. - **Government insurance** (Medicare, Medicaid, VA): Non-financial assistance like reimbursement support and education; financial aid unavailable. - **No insurance or underinsured**: Patient Assistance Program (PAP) provides **free medication** if you meet income and residency rules. **Key eligibility notes**: - Valid prescription for FDA-approved use. - U.S. resident (including territories like Puerto Rico). - For PAP: No federal/state-funded coverage; household income ≤500% Federal Poverty Level (FPL). ## Income Eligibility Breakdown The PAP targets low-income patients. While exact 2026 FPL figures depend on annual updates, here's a general table based on program guidelines (≤500% FPL). Check current FPL at healthcare.gov for precision. | Household Size | 100% FPL (approx.) | 500% FPL Threshold (approx.) | |---------------|---------------------|------------------------------| | 1 | $15,060 | $75,300 | | 2 | $20,440 | $102,200 | | 3 | $25,820 | $129,100 | | 4 | $31,200 | $156,000 | | +1 person | +$5,380 | +$26,900 | *Proof of income required: W-2s, pay stubs, or tax returns.* Commercial copay programs have no income limits but require private insurance. ## Insurance Requirements - **Commercial required for copay assistance**: Covers medication and potentially home infusion costs (as low as $0). Government plans ineligible for financial support. - **Non-financial aid available to all**: Includes prior auth help, appeals, nursing support, and pharmacist access—regardless of coverage. - **Medicare/Medicaid/VA**: Get education, delivery coordination, but no copay or free drug aid. - **Uninsured/underinsured**: PAP for free Lamzede if income-qualified. Chiesi's team of pharmacists, coordinators, reimbursement specialists, and nurses handles benefits verification. ## Step-by-Step Application Process 1. **Get your prescription**: Ensure your doctor prescribes Lamzede for an FDA-approved indication. 2. **Contact Chiesi Total Care**: Call **(888) 661-9260** (or 855-282-4883 per some resources) Mon-Fri, 7 AM-6 PM CT. They'll send the **Chiesi Total Care Enrollment Form**. 3. **Complete enrollment**: Fill out with your doctor. Include: - Valid Lamzede prescription. - Proof of income (for PAP). - Insurance details. Fax to 1-855-929-2828 if needed. 4. **Submit documents**: Enrollment form + prescription. HCP may fax on your behalf. 5. **Benefits investigation**: Team verifies coverage, handles prior auth/appeals. 6. **Approval & start**: Once approved, medication ships via home infusion or directly to you. **Multiple application methods**: Phone, fax, or online enrollment (scan QR where available). ## Timeline and Delivery Processing varies but similar Chiesi programs average **18 days** from Rx to first dose. Expect: - Enrollment: 1-3 days. - Insurance review/prior auth: 5-14 days. - Delivery: **Home infusion** or shipped to patient; worry-free refills with 24/7 pharmacist access. Infusion support ensures proper administration, storage, and disposal guidance. ## Alternatives if Denied - **Appeal denial**: Chiesi reimbursement specialists assist with insurance appeals. - **Foundation funding**: Team applies to additional foundations on your behalf. - **Switch programs**: Explore independent PAPs like PAN Foundation or NeedyMeds for alpha-mannosidosis. - **Discuss with doctor**: Alternative therapies or clinical trials via clinicaltrials.gov. - **State assistance**: Check Medicaid expansions or rare disease programs. ## Disclaimer This guide is for informational purposes only and based on publicly available Chiesi Total Care details as of 2026. Eligibility, benefits, and terms can change; **commercial/government insurance restrictions apply**. Not a substitute for medical/financial advice. Contact Chiesi at (888) 661-9260 for personalized help. Program may not cover all costs; patients in MA/RI may have home infusion limits. See full terms at chiesitotalcare.com.

Program information last verified: March 30, 2026