Kyprolis

Indicated For

Relapsed or refractory multiple myeloma

About This Medication

# Getting Kyprolis (Carfilzomib) at No Cost Through the Amgen Safety Net Foundation ## Who Qualifies for the Amgen Safety Net Foundation? If you have been prescribed Kyprolis (carfilzomib) for multiple myeloma and cannot afford it, the **Amgen Safety Net Foundation** may be able to provide it to you at no cost. This program is designed specifically for patients who are uninsured, underinsured, or whose insurance does not cover Kyprolis. To give you a quick sense of the income guidelines: a single-person household may qualify with an annual income up to **$75,300**. Your insurance status matters too — patients with Medicare Part D may qualify only if they meet specific hardship criteria, while those with no insurance or inadequate coverage are generally eligible to apply. --- ## About Kyprolis (Carfilzomib) Kyprolis (carfilzomib) is an injectable prescription medication made by Amgen. It is FDA-approved to treat adults with **relapsed or refractory multiple myeloma**, a type of blood cancer that has returned or stopped responding to prior treatment. Kyprolis belongs to a class of drugs called proteasome inhibitors, which work by interfering with the way cancer cells break down proteins. Because it is a specialty biologic administered in a clinical setting, Kyprolis carries a very high list price — often tens of thousands of dollars per treatment cycle — placing it out of reach for many patients without financial assistance. --- ## Income Eligibility: Full Breakdown The Amgen Safety Net Foundation uses income thresholds based on **500% of the Federal Poverty Level (FPL)**, which is the standard Amgen uses for its oncology assistance programs. The limits by household size are: | Household Size | Maximum Annual Income | |---|---| | 1 person | $75,300 | | 2 persons | $102,200 | | 3 persons | $129,100 | | 4 persons | $156,000 | Income is typically verified using your **most recent federal tax return** or **three months of recent pay stubs**. If your income has changed significantly since your last tax return — for example, due to job loss or a medical leave — you may be able to use current pay stubs instead. If your income is above these limits, you may still have options. Some applicants just over the threshold are reviewed on a case-by-case basis. You can also ask the program directly whether any hardship exceptions apply to your situation. See the "Alternatives If You Don't Qualify" section below for additional resources. --- ## Insurance Requirements Explained - **If you are uninsured:** You are a strong candidate for this program. Patients with no health insurance are among the primary groups the Amgen Safety Net Foundation was designed to help. You may apply directly and will need to confirm your uninsured status on the application. - **If you have Medicare Part D:** You may still qualify, but only if you meet **specific financial hardship criteria** set by the program. Medicare Part D patients are not automatically excluded, but approval is not guaranteed. Contact the program at **(866) 264-2778** to discuss your situation before applying. - **If you have private insurance that covers less than 50% of costs (or does not cover Kyprolis at all):** You may qualify as an underinsured patient. The program considers patients whose commercial insurance provides little or no coverage for this specific drug to be eligible. - **If you have Medicaid:** Patients covered by Medicaid are generally not eligible for manufacturer patient assistance programs, as Medicaid is considered active drug coverage. Contact your state Medicaid office or a patient navigator for alternative support. --- ## Step-by-Step: How to Apply **Step 1: Gather your documents.** Before starting, collect the following: a completed application form signed by both you and your prescriber, proof of income (your most recent federal tax return, W-2, or three months of pay stubs), and a valid prescription for Kyprolis. **Step 2: Download or request the application.** Visit **https://www.amgensafetynetfoundation.com** to access the online application or to download a paper form. You can also call **(866) 264-2778** to have a form mailed or faxed to you. **Step 3: Have your doctor complete their portion.** Your prescriber must sign the application. Many offices handle this routinely — ask your oncology clinic's financial navigator or medical assistant to assist with this step. **Step 4: Submit your application.** You may submit your completed application in one of three ways: - **Online:** through the application portal at https://www.amgensafetynetfoundation.com - **Phone:** by calling **(866) 264-2778** - **Fax:** by sending all documents to **(866) 218-4777** **Step 5: Wait for your decision.** The program typically completes its review within **2 business days** of receiving a complete application. **Step 6: Confirm next steps with your care team.** Once approved, your prescriber's office will be notified. You do not need to take additional action for pickup — medication is shipped directly to your prescriber or treatment facility. --- ## What to Expect: Timeline and Delivery After submitting a complete application, you can typically expect a decision within **2 business days**. Approval notification is sent to your prescriber. Kyprolis will be **shipped directly to your prescriber's office or infusion center** — you do not need to pick it up at a pharmacy or take any additional steps at the point of care. Your enrollment is valid for **one year**. Before your approval period ends, you will need to submit a **reauthorization** to continue receiving the medication. Your care team or a program representative will typically notify you when renewal is due. Keep your income documents updated so the process goes smoothly. --- ## Alternatives If You Don't Qualify **Biosimilars:** There are currently **no FDA-approved biosimilar alternatives** to Kyprolis. This means the Amgen Safety Net Foundation program is the primary manufacturer-based option for cost relief. **Savings card for insured patients:** If you have commercial (private) insurance and do not qualify for the free drug program, Amgen offers a **copay support card** through Amgen SupportPlus. This card may reduce your out-of-pocket costs. Visit **https://www.amgensupportplus.com/copay** to learn more. **State Pharmaceutical Assistance Programs (SPAPs):** Many states offer programs that help residents cover the cost of prescription drugs. Eligibility and benefits vary by state. Ask your oncology social worker or contact your state health department for details. **NeedyMeds.org:** This free, nonprofit database lists hundreds of assistance programs, including disease-specific funds and state programs. Visit **https://www.needymeds.org** to search by drug name or condition at no cost. --- > *This guide is for informational purposes only and does not constitute medical or legal advice. Eligibility determinations are made solely by Amgen. Program terms may change — verify current requirements at [https://www.kyprolis.com/support](https://www.kyprolis.com/support) before applying.* ---

Program information last verified: February 27, 2026