Kyprolis

Indicated For

relapsed or refractory multiple myeloma

About This Medication

# Amgen Safety Net Foundation Patient Guide: How to Get **Kyprolis** (carfilzomib) at Low or No Cost Kyprolis (carfilzomib) is a prescription medication used to treat multiple myeloma, a type of blood cancer, in adults, often in combination with other drugs like dexamethasone or daratumumab. This guide explains the **Amgen Safety Net Foundation** program, which provides **Kyprolis at no cost** to eligible uninsured or underinsured patients who meet income limits and other criteria.[1] ## Who Qualifies for the Program? The Amgen Safety Net Foundation helps U.S. residents (including Puerto Rico) who cannot afford their Amgen medications, like Kyprolis. You may qualify if you: - Have a household income at or below **400% of the Federal Poverty Level (FPL)**. - Are **uninsured** or **underinsured** (your insurance does not cover Kyprolis). - Are not eligible for Medicaid or Medicare's Low-Income Subsidy (Extra Help).[1] **Key exclusions**: Patients eligible for Medicaid, Medicare Extra Help, or those with other financial support options do not qualify. The program targets those facing financial hardship.[1] ## About Kyprolis (carfilzomib) **Kyprolis** is a targeted therapy called a proteasome inhibitor. It works by blocking enzymes that cancer cells need to survive, helping to slow or stop the growth of multiple myeloma cells. It's typically given as an intravenous (IV) infusion in a doctor's office or clinic, often weekly or twice weekly during treatment cycles. Common uses include: - Relapsed or refractory multiple myeloma (after other treatments). - In combination with other drugs for newly diagnosed cases. **Important safety note**: Kyprolis can cause serious side effects like heart problems, lung issues, low blood counts, and infusion reactions. Always discuss risks with your doctor and report symptoms promptly. This program provides the medicine but does not cover medical advice or monitoring.[2] ## Income Eligibility Breakdown Eligibility is based on **400% of the Federal Poverty Level (FPL)** or specific income caps, whichever is higher. For 2026, guidelines are: | Household Size | Maximum Annual Income | |---------------|-----------------------| | 1 (Individual) | $75,000 | | 2 (Couple) | $100,000 | | 3 | $125,000 | | 4 | $150,000 | *Add about $25,000 per additional family member. These are guidelines; exact FPL charts apply (400% FPL or less). Proof of income is required.*[1] ## Insurance Requirements - **Uninsured**: No prescription coverage at all.[1] - **Underinsured**: Insurance exists but excludes Kyprolis (or its generic/biosimilar). For **Medicare Part D** patients, you must: 1. Show you can't afford out-of-pocket costs. 2. Not qualify for Medicaid or Extra Help. 3. Meet your plan's prior authorization (PA) rules. 4. Have no other support options.[1] The program does **not** cover patients with full coverage or those eligible for government subsidies.[1] ## Step-by-Step Application Process 1. **Talk to your doctor**: They must prescribe Kyprolis and agree to receive shipments at their office. 2. **Contact Amgen Assist**: Call **(888) 447-3332** or **(866) 264-2778** (Mon-Fri, 9 a.m.-8 p.m. ET) to screen eligibility. New applicants start here.[1][3] 3. **Gather documents**: - Proof of income (tax returns, pay stubs, W-2s). - Proof of residency (utility bill, lease). - Proof of insurance status (denial letter or insurance card showing no Kyprolis coverage). - Valid prescription for Kyprolis.[1] 4. **Complete the form**: Download the Enrollment Form from the HCP portal or have your doctor submit via **https://www.amgensafetynetfoundation.com/hcp/apply-now**, fax (1-866-218-4777), or myAmgenPortal.com.[1][3] 5. **Submit**: Doctor's office handles final submission. Multiple methods available (online, phone, fax).[1] Your doctor or Amgen SupportPlus can guide you.[3] ## Timeline and Delivery - **Processing time**: Approximately **2-4 weeks** after complete submission.[1] - **Delivery**: Free Kyprolis shipped directly to your **physician's office** (not your home).[1] - **Start of benefits**: Once approved, medication begins upon doctor's request. ## Reauthorization and Refills **Reauthorization is required**. Currently enrolled patients get notifications from the Foundation to their healthcare provider (HCP) for renewal. You must continue meeting all criteria (income, insurance status). Contact Amgen Assist for refill steps.[1] ## Alternatives if Denied or No Coverage - **Amgen SupportPlus Co-Pay Program**: For commercially insured patients (not Medicare/Medicaid). Helps lower out-of-pocket costs. Enroll at AmgenSupportPlus.com or call (866) 264-2778.[3] - **KYPROLIS Patient Support**: Sign up for nurse navigators and referrals to other nonprofits.[2] - **Other options**: State programs, generic alternatives (none currently for Kyprolis), or nonprofits like PAN Foundation. No biosimilars available.[1] - **If denied**: Appeal with updated documents or explore why (e.g., income too high, insurance changes). Call for details.[1] ## Disclaimer This guide is for informational purposes only and based on 2026 program details, which may change. It does not guarantee approval—eligibility decided by Amgen Safety Net Foundation. Consult your healthcare provider for medical advice. Amgen provides referrals to independent programs as a courtesy; they control eligibility. Not affiliated with government programs. Verify current rules by calling **(888) 447-3332** or visiting the application site. Word count: 1028.

Program information last verified: March 30, 2026