Kynamro

Indicated For

Homozygous Familial Hypercholesterolemia (HoFH)

About This Medication

# Kynamro Patient Guide: How to Get Kynamro at Low or No Cost Kynamro (mipomersen) is a specialized medication available only through a restricted Risk Evaluation and Mitigation Strategy (REMS) program due to risks like hepatotoxicity. This guide explains access options, including third-party assistance programs like Prescription Hope, state Medicaid prior authorizations, and Medicare support, as no direct manufacturer patient assistance program from Genzyme is detailed in current sources.[1][4][7] ## About Kynamro **Kynamro (mipomersen sodium)** is an injectable oligonucleotide that inhibits Apo B-100 synthesis, used as an adjunct to lipid-lowering medications and diet. It reduces LDL-cholesterol, apolipoprotein B, total cholesterol, and non-HDL cholesterol in patients with **homozygous familial hypercholesterolemia (HoFH)**, a rare genetic condition causing extremely high cholesterol levels.[4][5][7][8] Kynamro carries a **black box warning** for hepatotoxicity (liver damage), so it's only prescribed by certified healthcare providers enrolled in the **Kynamro REMS Program**. Prescriptions must use a specific **Prescription Authorization Form**, submitted via fax (877-778-9008) or email (updated options as of 2015), and dispensed only through certified pharmacies. Contact the REMS program at 877-596-2676 for help.[4][5] HoFH patients often need this alongside maximum statin therapy, but only after failure, intolerance, or contraindication to standard treatments.[6] ## Who Qualifies for Assistance Direct manufacturer assistance from Genzyme is not specified in available data; access relies on REMS compliance, third-party programs, insurance, or government aid.[1][4] - **Medical eligibility**: Confirmed HoFH diagnosis via clinical or lab tests, prescribed by a REMS-certified provider (often a lipid disorder specialist).[4][6][7] - **Prescription Hope**: Open to individuals/families earning under $200,000/year. Provides Kynamro for a flat $60-70/month fee, working with any insurance. No fee if they can't obtain it.[1] - **Medicare Part D**: Extra Help for low-income (income/assets below limits: no premiums/deductibles, low copays). 2025 updates include $2,000 out-of-pocket cap and Prescription Payment Plan to spread costs.[2] - **State Medicaid (e.g., PA)**: Prior authorization for HoFH patients with prior lipid therapy failure, prescribed by REMS-enrolled specialist. Initial 6 months, renewals up to 12 months.[3][6] ## Income Eligibility Breakdown | Household | Prescription Hope | Medicare Extra Help (2025 est.) | State Medicaid Varies | |-----------|-------------------|--------------------------------|----------------------| | Individual | < $200,000/year[1] | Income ~$22,590; Assets ~$17,550[2] | State-specific FPL (e.g., 138% in expansion states) | | Couple | < $200,000/year[1] | Income ~$30,660; Assets ~$35,000[2] | Varies by state | | Family of 3 | < $200,000/year[1] | Add ~$5,000 income per person[2] | Varies | | Family of 4 | < $200,000/year[1] | Add ~$5,000 income per person[2] | Varies | **Notes**: Prescription Hope has broad income limits; Medicare Extra Help is stricter. Check state programs like PA PACE/PACENET.[1][2] ## Insurance Requirements Kynamro works with **any insurance**, including Medicare Part D. Prescription Hope fills gaps, capping costs at $60/month regardless of tiers.[1] For Medicare: - Apply for **Extra Help** to eliminate most costs.[2] - Use **Prescription Payment Plan** (2025+) to spread payments.[2] Medicaid requires prior auth form (e.g., PA fax 1-866-327-0191).[3] REMS mandates certified prescribers/pharmacies; no dispensing without form.[4] ## Step-by-Step Application 1. **Confirm Diagnosis**: Get HoFH evaluation from lipid specialist.[6][7] 2. **Find REMS-Certified Prescriber**: Doctor enrolls via Kynamro REMS (review PI, complete training).[4] 3. **Complete Prescription Authorization Form**: Prescriber attests to HoFH, safe-use conditions. Fax/email to REMS (877-778-9008 or email).[4][5] 4. **Enroll in Assistance**: - **Prescription Hope**: Apply online/phone; provide income proof if needed. $60/month.[1] - **Medicare Extra Help**: Apply via SSA.gov or 1-800-MEDICARE.[2] - **Medicaid**: Submit PA form to state (e.g., PA 1-800-537-8862).[3][6] 5. **Pharmacy**: Certified network dispenses post-REMS approval.[4] 6. **Contact**: REMS 877-596-2676; Prescription Hope via their site.[1][4] ## Timeline and Delivery - **REMS Approval**: Varies; submit form promptly. Initial Medicaid: 6 months; renewal 12 months.[6] - **Prescription Hope**: Fastest-growing program; pre-qualify quickly, monthly delivery.[1] - **Medicare**: Extra Help processing ~2-4 weeks; Payment Plan immediate opt-in.[2] Delivery via certified pharmacies; subcutaneous injection at home/clinic.[7] ## Alternatives if Denied - **Appeal** via REMS/prescriber or program (e.g., Medicaid reviewer judgment).[6] - **Other Assistance**: GoodRx coupons, state programs (search Medicare tool).[2] - **Medications**: PCSK9 inhibitors (initial 2 months PA), statins, or Juxtapid (similar REMS).[6] - **No Biosimilars**: None listed for Kynamro.[7] ## Disclaimer This guide synthesizes public sources as of 2026; programs change. Consult healthcare provider, REMS (877-596-2676), or Prescription Hope for personalized advice. Not medical/financial advice. Verify eligibility; Kynamro risks hepatotoxicity—monitor liver enzymes.[1][2][4][7] (Word count: 942)

Program information last verified: March 30, 2026