Koselugo

Indicated For

neurofibromatosis type 1 (NF1) plexiform neurofibromas

About This Medication

# Alexion OneSource Koselugo CoPay Program Patient Guide: How to Get Koselugo at Low or No Cost Koselugo (selumetinib) is an FDA-approved oral medication used to treat pediatric patients age 2 years and older with **neurofibromatosis type 1 (NF1)** who have **symptomatic, inoperable plexiform neurofibromas (PN)**. The **Alexion OneSource Koselugo CoPay Program** helps eligible patients with commercial insurance reduce out-of-pocket costs for Koselugo to **as little as $0**, covering copays, coinsurance, and deductibles up to an **annual maximum benefit of $26,000** (terms apply).[1][3] ## About Koselugo **Koselugo** is a targeted therapy called a **MEK inhibitor** that works by blocking proteins that cause tumor growth in NF1-PN, a rare genetic condition causing painful, debilitating tumors along nerve sheaths. It's available as **capsules (10 mg and 25 mg)** and **oral granules (5 mg and 7.5 mg)** for easier dosing in young children. Treatment is taken **twice daily on an empty stomach**. Common side effects include vomiting, rash, abdominal pain, diarrhea, headache, and fatigue; serious risks involve heart issues, eye problems, and infections—discuss with your doctor.[2][9] OneSource, Alexion's free patient support program, provides education on Koselugo, side effect management, and community resources alongside financial help.[6][8] ## Who Qualifies? Eligibility is **not based on income**—no financial screening required. You qualify if you meet **ALL** these criteria: - Enrolled in **Alexion OneSource** patient support program. - Have **commercial health insurance** covering Koselugo (but not 100% of costs). - Prescribed Koselugo for an **FDA-approved indication** (NF1-PN). - Reside in the **US or territories** (including Puerto Rico). - Financially responsible person is **18+ years old**.[1][3][4] **Not eligible** if on Medicare, Medicaid, federal/state-funded programs, or government insurance.[1][10] ## Income Eligibility Breakdown This program has **no income limits**. Here's a clear overview: | Household Size | Income Threshold | Eligible? | |---------------|------------------|-----------| | Individual | None | Yes, if other criteria met | | Couple | None | Yes, if other criteria met | | Family of 3 | None | Yes, if other criteria met | | Family of 4 | None | Yes, if other criteria met | | Any Size | Up to any income (no FPL % limit) | Yes, if other criteria met | **Notes**: Focus is on insurance type, not finances. Annual benefit caps apply and vary.[1][3] ## Insurance Requirements **Commercial insurance only**—private plans like employer-sponsored or marketplace coverage (e.g., Blue Cross, UnitedHealthcare). Excludes: - Medicare (Parts A/B/D, Advantage) - Medicaid - VA, Tricare, or other federal/state programs - Prison healthcare Your plan must cover **some** Koselugo costs; the program assists with the rest.[1][2][10] ## Step-by-Step Application Process 1. **Enroll in OneSource** (required first step): - Call **1-888-765-4747** (M-F, 8:30 AM-8 PM ET) for help in any language. - Download form from AlexionOneSource.com/kos/get-started. - Complete, sign, and email to OneSource@Alexion.com or fax 1-800-420-5150. - OneSource calls within a few business days to confirm.[5][3] 2. **Get Your Prescription**: Doctor prescribes Koselugo for FDA-approved use. Sent to **Onco360 specialty pharmacy**.[4][9] 3. **Verify Insurance**: OneSource checks benefits, prior authorizations (PA). They handle appeals if needed.[4] 4. **Enroll in CoPay Program**: Automatic eligibility check post-OneSource enrollment. Use copay card at pharmacy or submit reimbursement claims.[1][7] 5. **Fill Prescription**: Onco360 coordinates; PA approval ships to patient or doctor's office.[4] **Multiple application methods**: Online enrollment, phone, fax, or mail.[3] ## Timeline and Delivery - **Enrollment**: OneSource contact in **2-3 business days**.[10] - **Insurance/PA**: Varies by plan (days to weeks); OneSource supports.[4] - **Approval/Delivery**: Once PA approved, Onco360 ships **directly to you or doctor's office** via standard mail (free).[4] - **Copay Assistance**: Immediate at pharmacy with card; reimbursements within **365 days** of service (submit EOB/proof).[1] **Reauthorization**: Yes, required periodically—OneSource handles renewals; auto-enroll if eligible.[3][1] ## Alternatives if Denied or Ineligible - **Appeal Denial**: OneSource Field Reimbursement Manager helps with insurance appeals.[4] - **Government Insurance**: OneSource connects to third-party charities (e.g., Patient Access Network, HealthWell Foundation).[10] - **Uninsured/Underinsured**: Explore Alexion OneSource resources or independent foundations. - **No Biosimilars**: Koselugo has none available.[4][10] Call OneSource for personalized options. ## Important Disclaimer This guide is for informational purposes only and not a guarantee of coverage or assistance. Eligibility, benefits, and terms can change; annual max applies ($26,000). Not valid where prohibited by law. Consult your doctor, insurer, and OneSource (1-888-765-4747) for latest details. Alexion reserves rights to modify/amend program. Not health/financial advice.[1][3]

Program information last verified: March 30, 2026