Koselugo

Alexion OneSource Koselugo CoPay Program Patient Guide: How to Get Koselugo at Low or No Cost

Koselugo (selumetinib) is an FDA-approved oral medication used to treat pediatric patients age 2 years and older with neurofibromatosis type 1 (NF1) who have symptomatic, inoperable plexiform neurofibromas (PN). The Alexion OneSource Koselugo CoPay Program helps eligible patients with commercial insurance reduce out-of-pocket costs for Koselugo to as little as $0, covering copays, coinsurance, and deductibles up to an annual maximum benefit of $26,000 (terms apply).[1][3]

About Koselugo

Koselugo is a targeted therapy called a MEK inhibitor that works by blocking proteins that cause tumor growth in NF1-PN, a rare genetic condition causing painful, debilitating tumors along nerve sheaths. It's available as capsules (10 mg and 25 mg) and oral granules (5 mg and 7.5 mg) for easier dosing in young children. Treatment is taken twice daily on an empty stomach. Common side effects include vomiting, rash, abdominal pain, diarrhea, headache, and fatigue; serious risks involve heart issues, eye problems, and infections—discuss with your doctor.[2][9]

OneSource, Alexion's free patient support program, provides education on Koselugo, side effect management, and community resources alongside financial help.[6][8]

Who Qualifies?

Eligibility is not based on income—no financial screening required. You qualify if you meet ALL these criteria:

• Enrolled in Alexion OneSource patient support program.
• Have commercial health insurance covering Koselugo (but not 100% of costs).
• Prescribed Koselugo for an FDA-approved indication (NF1-PN).
• Reside in the US or territories (including Puerto Rico).
• Financially responsible person is 18+ years old.[1][3][4]

Not eligible if on Medicare, Medicaid, federal/state-funded programs, or government insurance.[1][10]

Income Eligibility Breakdown

This program has no income limits. Here's a clear overview:

Notes: Focus is on insurance type, not finances. Annual benefit caps apply and vary.[1][3]

Insurance Requirements

Commercial insurance only—private plans like employer-sponsored or marketplace coverage (e.g., Blue Cross, UnitedHealthcare). Excludes:

• Medicare (Parts A/B/D, Advantage)
• Medicaid
• VA, Tricare, or other federal/state programs
• Prison healthcare

Your plan must cover some Koselugo costs; the program assists with the rest.[1][2][10]

Step-by-Step Application Process

1. Enroll in OneSource (required first step):

   • Call 1-888-765-4747 (M-F, 8:30 AM-8 PM ET) for help in any language.
   • Download form from AlexionOneSource.com/kos/get-started.
   • Complete, sign, and email to OneSource@Alexion.com or fax 1-800-420-5150.
   • OneSource calls within a few business days to confirm.[5][3]

2. Get Your Prescription: Doctor prescribes Koselugo for FDA-approved use. Sent to Onco360 specialty pharmacy.[4][9]

3. Verify Insurance: OneSource checks benefits, prior authorizations (PA). They handle appeals if needed.[4]

4. Enroll in CoPay Program: Automatic eligibility check post-OneSource enrollment. Use copay card at pharmacy or submit reimbursement claims.[1][7]

5. Fill Prescription: Onco360 coordinates; PA approval ships to patient or doctor's office.[4]

Multiple application methods: Online enrollment, phone, fax, or mail.[3]

Timeline and Delivery

• Enrollment: OneSource contact in 2-3 business days.[10]
• Insurance/PA: Varies by plan (days to weeks); OneSource supports.[4]
• Approval/Delivery: Once PA approved, Onco360 ships directly to you or doctor's office via standard mail (free).[4]
• Copay Assistance: Immediate at pharmacy with card; reimbursements within 365 days of service (submit EOB/proof).[1]

Reauthorization: Yes, required periodically—OneSource handles renewals; auto-enroll if eligible.[3][1]

Alternatives if Denied or Ineligible

• Appeal Denial: OneSource Field Reimbursement Manager helps with insurance appeals.[4]
• Government Insurance: OneSource connects to third-party charities (e.g., Patient Access Network, HealthWell Foundation).[10]
• Uninsured/Underinsured: Explore Alexion OneSource resources or independent foundations.
• No Biosimilars: Koselugo has none available.[4][10]

Call OneSource for personalized options.

Important Disclaimer

This guide is for informational purposes only and not a guarantee of coverage or assistance. Eligibility, benefits, and terms can change; annual max applies ($26,000). Not valid where prohibited by law. Consult your doctor, insurer, and OneSource (1-888-765-4747) for latest details. Alexion reserves rights to modify/amend program. Not health/financial advice.[1][3]