ISTURISA

Indicated For

Cushing's syndrome, Cushing's disease

About This Medication

# R.A.R.E. Patient Support Program Patient Guide: How to Get ISTURISA (osilodrostat) at Low or No Cost ## About ISTURISA (osilodrostat) **ISTURISA (osilodrostat)** is a prescription medication approved by the FDA to treat adults with Cushing's syndrome who have high cortisol levels (endogenous hypercortisolemia). It works by blocking an enzyme that helps produce cortisol, helping to lower these elevated levels when surgery is not an option or has not cured the condition.[6] Cushing's syndrome can cause symptoms like weight gain, high blood pressure, fatigue, and mood changes due to excess cortisol. ISTURISA offers a targeted treatment for those who cannot undergo or have not benefited from pituitary surgery.[1][6] This guide explains the **R.A.R.E. Patient Support Program** from Recordati Rare Diseases, which provides financial assistance, access support, and education for ISTURISA patients. Enrollment happens automatically with your prescription, but opting in unlocks extra benefits like a dedicated Patient Liaison.[1][2] ## Who Qualifies for the R.A.R.E. Program? The program targets **uninsured or underinsured patients** facing financial hardship. It offers **needs-based assistance** for those who meet specific financial requirements, though exact income limits are not publicly detailed and are evaluated case-by-case.[4] Ideal candidates include: - Adults with Cushing's syndrome prescribed ISTURISA. - Patients without insurance or with insurance that doesn't fully cover the high-cost specialty drug. - Those demonstrating financial need through income proof. **Key perks include:** free or low-cost medication, copay help (as low as $20/month for commercially insured), 24/7 pharmacist access, Nurse Educators, and shipment tracking.[1][4] ## Income Eligibility Breakdown Specific Federal Poverty Level (FPL) thresholds like 400% or 500% are not publicly listed; eligibility is **needs-based** with individualized review. Contact the program for a pre-screening.[1][4] | Household Size | Estimated Threshold | Notes | |---------------|---------------------|-------| | Individual | Case-by-case | Proof of income required; no fixed public limit. | | Couple | Case-by-case | Evaluated based on total household income. | | Family of 3 | Case-by-case | Financial hardship prioritized for uninsured/underinsured. | | Family of 4+ | Case-by-case | Recent pay stubs, tax returns often needed. | *Table based on program notes; call (888) 855-7273 for personalized assessment.*[1][4] ## Insurance Requirements - **Uninsured**: Full patient assistance possible. - **Underinsured**: Copay assistance or free drug if out-of-pocket costs are high.[1][4] - **Commercially insured**: R.A.R.E. Copay Program may reduce costs to $20/month.[4] - **Medicare/Medicaid**: Limited; explore foundations like HealthWell (up to $10,000/year for Cushing's).[4][8] The program includes **Insurance Specialists** to help with prior authorizations, appeals, and coverage optimization. Letters of Medical Necessity templates are available.[1][9] ## Step-by-Step Application Process 1. **Get Prescribed**: Ask your doctor for ISTURISA. They complete the **Patient Prescription Form** (includes dosing, ICD-10 code, allergies).[3] 2. **Enroll Automatically**: Prescription enrollment in R.A.R.E. occurs via fax to Anovo Specialty Pharmacy (855-813-2039).[1][3] 3. **Opt-In for Full Support**: Complete the online **Program Enrollment Opt-In Form** for Patient Liaison, education, and financial help.[1][2] 4. **Submit Documents**: Provide proof of income (pay stubs, tax returns), residency (utility bill), insurance info, and prescription.[1] 5. **Call for Help**: Dial (888) 855-RARE (7273) for reimbursement team support, 24/7 pharmacists, or Nurse Educators.[1][3] 6. **Application Methods**: Phone, fax via prescriber, or online opt-in (multiple options).[1][3] Your Patient Liaison (PL) will guide you, answer questions, and connect resources at no extra cost.[2] ## Timeline and Delivery - **Processing**: Varies; prior authorizations may take 30 days (or 72 hours expedited).[8] Reauthorization required periodically.[1] - **Delivery**: Shipped directly via **Anovo Specialty Pharmacy** after approval.[1][3] - **Refills**: Handled through reauthorization; your PL tracks adherence.[1][2] Expect support every step, including shipment tracking.[1] ## Alternatives if Denied - **Appeal**: Use program-provided Letter of Medical Necessity templates.[9] - **Other Funds**: HealthWell Foundation (Cushing's, up to $10,000/year), Chronic Disease Fund.[4][8] - **Copay Cards**: R.A.R.E. Copay Program for commercial insurance ($20/month).[4] - **State Programs**: Check Ohio or your state's pharmaceutical assistance.[8] - **No Biosimilars**: ISTURISA has none listed.[1] ## Disclaimer This guide is for informational purposes based on publicly available data as of 2026. Eligibility, terms, and availability can change; always verify with Recordati Rare Diseases at (888) 855-7273 or your healthcare provider. Not medical advice. ISTURISA has risks; discuss with your doctor. Program not guaranteed; individual results vary. Word count: 950.

Program information last verified: March 30, 2026