IBTROZI

Indicated For

ROS1-positive NSCLC

About This Medication

# NuvationConnect Patient Assistance Program Patient Guide: How to Get IBTROZI (taletrectinib) at Low or No Cost IBTROZI (taletrectinib) is a targeted therapy for adults with locally advanced or metastatic ROS1-positive non-small cell lung cancer (NSCLC), either as initial treatment or after prior ROS1 inhibitor therapy. The **NuvationConnect Patient Assistance Program** from **Nuvation Bio** provides **free medication** to eligible patients who are uninsured or have inadequate insurance coverage, helping ensure access despite financial barriers[1][2][3]. ## About IBTROZI (taletrectinib) IBTROZI is an oral ROS1 tyrosine kinase inhibitor designed to block cancer cell growth in ROS1-positive NSCLC, a subtype affecting about 1-2% of NSCLC cases. It offers robust brain penetration, making it effective for patients with central nervous system metastases. Common side effects include edema, diarrhea, increased liver enzymes, fatigue, and dizziness—your doctor will monitor these closely. Always take as prescribed, typically 600 mg twice daily with food[2][3][4]. NuvationConnect supports your entire journey with financial aid, insurance navigation, nurse case managers, and educational resources. It's not just assistance; it's personalized help from diagnosis through treatment[1][2][4]. ## Who Qualifies? Eligibility focuses on financial need and insurance status rather than strict income caps. Key criteria include: - **U.S. residency** and a valid prescription from a licensed U.S. healthcare provider. - **Inadequate insurance coverage or uninsured**: This means no prescription insurance, or your plan doesn't cover IBTROZI (you're responsible for 100% cost—"functionally uninsured").[1][2][3] - **Income-based review**: While specific Federal Poverty Level (FPL) thresholds aren't publicly detailed, programs like this typically assist households below 400-500% FPL, evaluated case-by-case with proof of hardship. Expect verification of annual gross income (salary, Social Security, disability, etc.) against household size[5][6][7]. - **Outpatient treatment** (not inpatient). - No government assistance restrictions beyond Medicare eligibility checks. **Medicare patients**: May qualify if functionally uninsured for IBTROZI, but Extra Help denial proof might be needed[6][8]. ## Income Eligibility Breakdown NuvationConnect reviews income holistically, but here's a general table based on similar programs (e.g., <500% FPL). Contact them for your exact assessment—no fixed thresholds listed[5][6][7]. | Household Size | Estimated Max Annual Income (400% FPL) | Estimated Max (500% FPL) | |----------------|---------------------------------------|--------------------------| | 1 (Individual) | $60,240 | $75,300 | | 2 (Couple) | $81,760 | $102,200 | | 3 | $103,280 | $129,100 | | 4 | $124,800 | $156,000 | *Notes*: Add ~$21,520 per person for larger families (400% FPL). Provide tax returns, W-2s, pay stubs, or benefit statements. Adjustments for high medical costs possible[5][7]. ## Insurance Requirements You must have **inadequate insurance coverage or be uninsured** for IBTROZI. This includes: - No prescription drug coverage. - Coverage exists, but IBTROZI is excluded or prior authorization denied. - High out-of-pocket costs making it unaffordable. NuvationConnect starts with **Benefit Investigation** to confirm coverage gaps, plus **Quick Start** for payer delays[2]. Commercially insured patients may access copay help separately; this PAP is for uninsured/underserved[1][10]. ## Step-by-Step Application Process Applications use **multiple methods**—online, phone, or forms—for flexibility[1][3]. 1. **Discuss with your doctor**: Confirm IBTROZI prescription and NuvationConnect eligibility. 2. **Visit NuvationConnect.com** or call **1-877-NUV-CON1 (1-877-688-2661)** (Mon-Fri, typical business hours). Prescribers enroll via portal or phone[1][3]. 3. **Complete enrollment**: Provide patient info, income proof (tax return/W-2, pay stubs, SS/disability statements), insurance details (or proof of no coverage), and prescriber signature[5][6][7]. 4. **Submit**: Online portal, phone assist, fax/mail per instructions. Nurse case manager guides you[2][4]. 5. **Verification**: Program checks income, insurance via eBV (every 6 months)[5]. No app fee; third-party fees not required[6]. ## Timeline and Delivery Processing takes **2-4 weeks** typically, like similar programs—faster for urgent cases via Quick Start[2][8]. You'll get approval/denial letter. Once approved, medication is **shipped free to you via specialty pharmacies** (e.g., direct to home). Enrollment often 12 months, rolling or calendar-year for Medicare[5][6]. ## Alternatives if Denied - **Appeal**: Submit more docs or insurance updates. - **Copay programs**: For commercial insurance via NuvationConnect. - **Other PAPs**: State programs, NeedyMeds, RxAssist, or manufacturer copay cards. - **Quick Start**: Bridge therapy during delays[2]. - **Financial aid**: Nurse navigators connect to grants[1][4]. ## Disclaimer This guide is for informational purposes based on available data as of 2026. Eligibility, terms subject to change—Nuvation Bio reserves rights. Not medical/financial advice. Consult your doctor, call **1-877-688-2661**, or visit NuvationConnect.com for latest details. Program may end or modify without notice[1][3][8]. (Word count: 1028)

Program information last verified: March 30, 2026