GIVLAARI

Indicated For

Acute Hepatic Porphyria

About This Medication

# Alnylam Assist Patient Assistance Program: Your Guide to Affordable GIVLAARI ## What is GIVLAARI and Who Needs It? GIVLAARI (givosiran) is a prescription medication used to treat acute hepatic porphyria (AHP), a rare inherited blood disorder that causes sudden, severe abdominal pain, neurological symptoms, and other serious complications. GIVLAARI is an innovative RNA interference therapy that works by reducing the production of harmful substances in the liver that trigger these attacks. Because GIVLAARI is a specialty medication for a rare condition, it can be very expensive. The Alnylam Assist Patient Assistance Program exists to help eligible patients access this life-changing medication at little or no cost. ## About the Alnylam Assist Program Alnylam Pharmaceuticals, the manufacturer of GIVLAARI, offers the Alnylam Assist Patient Assistance Program to help uninsured and underinsured patients afford their medications. This program can provide GIVLAARI at no cost or reduced cost to qualifying patients, regardless of their ability to pay. ## Who Can Apply? You may be eligible for the Alnylam Assist program if you: - Have been prescribed GIVLAARI by your doctor for an on-label use (acute hepatic porphyria) - Are a U.S. resident - Are uninsured or "functionally uninsured" (your insurance doesn't cover GIVLAARI or your out-of-pocket costs are too high) - May be eligible if you have Medicare Part D (contact the program directly to confirm) - Meet the income eligibility requirements (see table below) **Note:** "Functionally uninsured" means you have insurance, but it doesn't provide adequate coverage for GIVLAARI, making the medication unaffordable for you. ## Income Eligibility Income limits vary based on your household size. The program uses federal poverty guidelines as a reference but may consider applications above these thresholds on a case-by-case basis. Contact Alnylam Assist directly or visit their website for current income limits, as they are updated annually. If your household income is above the standard threshold, don't automatically assume you're ineligible—the program reviews individual circumstances and may be able to help. ## Insurance Requirements - **Uninsured patients:** Fully eligible to apply - **Underinsured patients:** Eligible if GIVLAARI is not covered by your insurance or if your copay/coinsurance is too high to afford - **Medicare Part D patients:** May be eligible—contact the program to discuss your specific situation - **Medicaid patients:** Coverage varies by state; work with your healthcare provider or the program to understand your options ## Documents You'll Need Before you start your application, gather these documents: 1. **Proof of income** (last 2 months of pay stubs, tax return, Social Security statement, or unemployment benefits letter) 2. **Proof of residency** (utility bill, lease, or mortgage statement dated within the last 2 months) 3. **Proof of insurance status** (insurance card or letter stating you're uninsured; if you have coverage, documentation of your plan) 4. **Valid prescription** for GIVLAARI from your doctor 5. **Medical documentation** confirming your acute hepatic porphyria diagnosis (on-label use) ## How to Apply The Alnylam Assist program offers **multiple application methods** for your convenience: ### Method 1: Online Application Visit **https://www.alnylamassist.com/hcp/givlaari/financial-assistance** and complete the online application. You can upload your supporting documents directly through the secure portal. ### Method 2: Mail or Fax Contact Alnylam Assist to request a paper application form, then mail or fax it along with your documents. ### Method 3: Work with Your Healthcare Provider Your doctor's office, nurse, or patient advocate may be able to help you apply or submit the application on your behalf. ## Step-by-Step Application Process **Step 1: Gather your documents** (see list above) **Step 2: Choose your application method** (online, mail, or with your healthcare provider's help) **Step 3: Complete the application** with accurate personal, financial, and insurance information **Step 4: Submit your documents** along with your completed application **Step 5: Wait for benefit verification** — the program typically reviews applications within **2 business days** **Step 6: Receive approval notice** via mail or email **Step 7: Get your medication** — once approved, GIVLAARI will be shipped either to you directly or to your physician's office, usually within 1-2 weeks ## Timeline and Delivery - **Benefit verification:** 2 business days - **Approval decision:** Usually within 5-7 business days of submission - **Medication delivery:** Typically ships within 1-2 weeks after approval - **Delivery location:** Your home or your healthcare provider's office (your choice) ## What Happens After Approval? Once you're approved and receiving GIVLAARI through the assistance program: - Your medication will be shipped on a regular schedule (typically monthly or as prescribed) - You'll continue receiving GIVLAARI at no cost or reduced cost as long as you remain eligible - **Reauthorization is required annually** — you'll need to submit updated financial and insurance information each year to maintain your benefits - The program will contact you before your authorization expires to guide you through the renewal process ## Other Ways to Save on GIVLAARI If you don't qualify for the patient assistance program or want to explore additional savings options: - **Savings Card:** Check the Alnylam Pharmaceuticals website for any available manufacturer discount cards or coupons - **Insurance Appeals:** If your insurance denies coverage, ask your doctor about filing an appeal - **State Programs:** Some states offer pharmaceutical assistance programs for rare diseases - **Patient Advocacy Organizations:** Organizations focused on porphyria may have additional resources and information ## What If Your Application Is Denied? If you're denied assistance, don't give up. The program can explain why and may suggest next steps, such as: - Reapplying with updated financial information - Exploring other payment assistance options - Working with your healthcare provider to find alternatives - Contacting a patient advocacy organization for your condition You have the right to request a reconsideration of your application. ## Important Legal Information This guide provides general information about the Alnylam Assist Patient Assistance Program for GIVLAARI. Program eligibility, requirements, and benefits may change. Always verify current information directly with the program before applying. This guide is not medical advice and does not replace guidance from your healthcare provider. GIVLAARI should only be used under the supervision of a qualified physician who has diagnosed you with acute hepatic porphyria. ## Questions? For more information about the Alnylam Assist Program, visit: **https://www.alnylamassist.com/hcp/givlaari/financial-assistance** You can also contact the program through their website or ask your healthcare provider for assistance.

Program information last verified: March 25, 2026