GAVRETO

Indicated For

RET fusion-positive NSCLC, RET fusion-positive or RET-mutant thyroid cancer

About This Medication

# RIGEL ONECARE Patient Guide: How to Get GAVRETO (pralsetinib) at Low or No Cost GAVRETO (pralsetinib) is a targeted therapy medication manufactured by Rigel Pharmaceuticals, used to treat certain types of advanced lung cancer and thyroid cancer with specific genetic mutations, such as RET fusion-positive non-small cell lung cancer (NSCLC) or RET-mutant medullary thyroid cancer (MTC).[2][4] The **RIGEL ONECARE** program helps eligible patients access GAVRETO through copay assistance, free drug supply options, and other support services, potentially reducing costs to as little as $0 per prescription.[2][4] ## About GAVRETO and Why Assistance Matters GAVRETO is an oral prescription medicine that targets RET gene alterations, helping to slow cancer growth in adults with specific RET-driven cancers.[2] Treatment often involves daily capsules, but its high list price can create financial barriers for many patients. **RIGEL ONECARE** bridges this gap by offering comprehensive support, including benefits investigation, nurse navigation, adherence reminders, and financial aid tailored to your insurance and income situation.[1][2][4] This program is fully trained to handle GAVRETO prescriptions, whether filled through specialty pharmacies or in-office dispensing.[4] Rigel Pharmaceuticals designs these services to make therapy accessible from diagnosis through ongoing treatment. Services include help with prior authorizations, appeals, product education, and phone support from dedicated nurses.[2][4] With costs potentially exceeding thousands per month without aid, RIGEL ONECARE ensures more patients can focus on health rather than bills.[8] ## Who Qualifies for RIGEL ONECARE? Eligibility varies by program component—copay assistance or free drug supply—but generally targets U.S. residents (including Puerto Rico) aged 18+ facing affordability challenges.[5][6][8] Key groups include: - Patients with **commercial insurance** seeking copay help. - **Uninsured or functionally uninsured** patients needing free medication.[8] - Those experiencing insurance delays or denials. **Programs are needs-based with restrictions; not all applicants qualify.** Government insurance like Medicare or Medicaid typically excludes copay aid but may allow other support like free drug for delays.[5] ## Income Eligibility Breakdown Specific Federal Poverty Level (FPL) thresholds are not publicly detailed, but the program is **needs-based** for uninsured/underinsured patients.[6][8] Copay assistance focuses on commercial insurance holders regardless of income (within benefit caps), while free drug supply emphasizes financial need.[5][8] Contact RIGEL ONECARE for personalized assessment, as criteria can change. | Household Size | Estimated Income Threshold | Notes | |---------------|----------------------------|-------| | Individual | Needs-based (call for details) | Uninsured/underinsured prioritized[8] | | Couple | Needs-based (call for details) | U.S. resident required[6] | | Family of 3 | Needs-based (call for details) | 18+ years old[5] | | Family of 4 | Needs-based (call for details) | Restrictions apply | Always verify with the program, as exact limits depend on current guidelines.[3] ## Insurance Requirements - **Commercial insurance**: Eligible for copay assistance (as low as $0 per fill, up to annual limits like $25,000 seen in similar programs).[2][4][5] - **Medicare/Medicaid/government insurance**: Ineligible for copay aid; may qualify for temporary free drug if coverage delayed >5 business days.[5] - **Uninsured**: Access free drug supply if needs-based criteria met.[8] RIGEL ONECARE starts with a benefits investigation to confirm coverage and identify aid options.[1][4] ## Step-by-Step Application Process 1. **Discuss with your doctor**: Ask your healthcare provider (HCP) to prescribe GAVRETO and initiate support. They can download the enrollment form from RigelONECARE.com.[4] 2. **Contact RIGEL ONECARE**: Call **1-833-RIGELOC (1-833-744-3562)** Monday-Friday, 8 a.m.-8 p.m. ET. Nurses will guide you on qualifying programs.[2][4] 3. **Complete enrollment**: HCP and patient fill out the form (similar to REZLIDHIA's: patient info, insurance copies, authorization).[5][8] Fax to **833-397-4435**.[5][8] 4. **Submit documents**: Include insurance cards (both sides), proof of residency/income if requested.[5] 5. **Await approval**: Team reviews and notifies you/HCP.[1] 6. **Enroll in copay if eligible**: Visit GAVRETOcopay.com for commercial insurance aid.[2][4] The process is streamlined; nurses handle much of the coordination.[2] ## Timeline and Delivery Processing time varies but aims for quick turnaround—temporary free drug available for delays >5 days.[5] Expect initial response within days of submission; full approval may take 1-2 weeks. Medication ships via specialty pharmacy or in-office pickup.[4] Refills follow reauthorization if required (program-specific).[1] Track via phone support.[2] ## Alternatives if Denied or Ineligible - **Appeal insurance denial**: RIGEL ONECARE provides prior auth/appeals help.[1][4] - **Other assistance**: Explore RxAssist.org for Rigel programs or general PAPs.[3] - **Patient Access Network (PAN) Foundation** or similar nonprofits for cancer drugs. - **Specialty pharmacy financial aid** or state programs. - **Clinical trials** via Rigel's policy if investigational access needed.[9] Contact the hotline for tailored options.[2] ## Important Disclaimer This guide is for informational purposes based on available public data as of 2026 and is not medical/financial advice. Eligibility, terms, and availability can change; **always confirm directly with RIGEL ONECARE at 1-833-744-3562 or RigelONECARE.com**.[1][2] Consult your doctor before starting/stopping GAVRETO. Programs may have restrictions, and free drug/copay aid is not guaranteed. Rigel Pharmaceuticals reserves rights to modify/discontinue services.[4][5] Word count: 1028.

Program information last verified: March 30, 2026