Eplontersen

Indicated For

Polyneuropathy of hereditary transthyretin-mediated amyloidosis

About This Medication

# Eplontersen Patient Assistance Guide: Affordable Access to Your Medication ## What Is This Guide? Eplontersen is a prescription medication used to treat polyneuropathy caused by hereditary transthyretin-mediated amyloidosis (hATTR). This guide helps you understand how to access eplontersen at reduced or no cost if you're uninsured or underinsured. ## Important Notice About Eplontersen Assistance There is currently **no active manufacturer prescription assistance program (PAP)** through the drug maker for eplontersen. However, this does not mean you cannot access affordable medication. This guide explains your other options and resources. ## Who Can Get Help? You may qualify for assistance if you meet these criteria: - **U.S. resident** with a valid prescription from your doctor - **Income falls below certain limits** (limits vary by program and family size—typically ranging from $20,000 to $50,000+ annually for individuals, higher for families) - **Uninsured or underinsured** (insurance doesn't cover the medication or you have high out-of-pocket costs) - **Not enrolled in Medicare** (though see FAQ section for Medicare details) Income limits vary significantly depending on which assistance program or nonprofit organization you work with, so don't assume you're ineligible based on income alone. ## Insurance Coverage Before seeking patient assistance, check your current insurance: - **Private Insurance**: Contact your insurance company to confirm coverage and copay amounts. Some plans may cover eplontersen with prior authorization from your doctor. - **Medicaid**: Coverage varies by state. Contact your state Medicaid office to verify eligibility. - **Medicare**: See the FAQ section below for specific information about Medicare and eplontersen. - **Uninsured**: If you have no insurance, patient assistance programs exist to help you access medication at no cost or reduced cost. ## How to Access Affordable Eplontersen Since there is no manufacturer program, follow these steps: ### Step 1: Talk to Your Doctor Discuss medication costs with your prescribing physician. Doctors often have resources, contacts with pharmaceutical companies, or knowledge of nonprofit programs that can help. They may also know of clinical trials or hospital-based assistance. ### Step 2: Contact Nonprofit Organizations Several nonprofit groups help patients access expensive medications: - **Patient Advocate Foundation** (800-532-5274) - **National Organization for Rare Disorders (NORD)** (800-999-6673) - **Amyloidosis Foundation** (for hATTR-specific support) - **Needy Meds Database** (free online directory of assistance programs) These organizations can connect you with programs based on your specific diagnosis and financial situation. ### Step 3: Gather Required Documents When applying for assistance, you'll typically need: - **Proof of income** (recent tax returns, pay stubs, or benefit statements) - **Valid prescription** from your doctor - **Proof of U.S. residency** - **Insurance information** (if applicable) ### Step 4: Submit Your Application Applications are submitted through nonprofit programs or hospital financial assistance departments. Processing times vary, but expect 2–4 weeks for approval. ## What You Need to Know - **No Reauthorization Required**: Once approved, you typically don't need to reapply yearly unless your income or insurance status changes significantly. - **No Savings Card Available**: There is no manufacturer discount card for eplontersen, making nonprofit assistance and hospital programs your primary resources. - **No Biosimilars**: Currently, there are no generic or biosimilar versions of eplontersen available. - **Timeline**: From application to receiving medication usually takes 2–4 weeks, though urgent cases may be expedited. ## If You're Denied If your initial application is denied: - Ask why you were denied (income, insurance, or other reasons) - Request an appeal if circumstances have changed - Contact your doctor's financial counselor for alternative programs - Explore state pharmaceutical assistance programs specific to your state ## Next Steps 1. **Call your doctor's office** and ask to speak with their financial counselor or patient advocate. 2. **Contact NORD or the Amyloidosis Foundation** for hATTR-specific resources. 3. **Gather your financial documents** to have ready for any application. 4. **Ask your doctor about clinical trials**, which sometimes provide free medication. You don't have to pay full price for eplontersen. Resources exist to help—start the conversation with your healthcare team today.

Program information last verified: March 25, 2026