ENSPRYNG

Genentech Patient Foundation and ENSPRYNG Co-pay Program Patient Guide: How to Get ENSPRYNG (satralizumab-mwge) at Low or No Cost

ENSPRYNG (satralizumab-mwge) is a prescription medication used to treat certain autoimmune conditions like neuromyelitis optica spectrum disorder (NMOSD) in adults and children. The Genentech Patient Foundation and ENSPRYNG Co-pay Program help eligible patients access this important drug at low or no cost, depending on insurance status and financial need.[1][2][6]

About ENSPRYNG and Why Assistance Matters

ENSPRYNG is a biologic therapy given by subcutaneous injection, typically every 4 weeks after initial doses, to reduce relapses in NMOSD, a rare disease affecting the optic nerves and spinal cord. Treatment costs can exceed tens of thousands of dollars annually without help, making patient assistance programs essential for many.[6] Genentech, the manufacturer, offers two main programs:

• Genentech Patient Foundation: Provides free medication for up to one year (renewable) to uninsured, underinsured, or insured patients with high out-of-pocket costs.[1][7]
• ENSPRYNG Co-pay Program: Covers co-pays, deductibles, and co-insurance for commercially insured patients, reducing costs to as low as $0 per fill (up to program limits).[program details]

These programs ensure continuity of care, especially since reauthorization is required annually.[program details][7]

Who Qualifies?

Eligibility varies by insurance and income. There are no strict federal poverty level (FPL) cutoffs listed; instead, requirements are tailored:[program details][6]

• Uninsured patients: Qualify based on household income typically under $150,000 (exceptions apply) and financial need.[6]
• Insured patients: Must have coverage for ENSPRYNG but face high costs, like an out-of-pocket maximum over 7.5% of yearly income.[6]
• Commercially insured: Eligible for co-pay help if not on government insurance.[program details]

Key exclusions: Medicare patients generally do not qualify for the Foundation (co-pay programs have limits); patients in Accumulator/Maximizer plans or required to use AFP vendors are ineligible.[4][7]

Income Eligibility Breakdown

Income thresholds depend on insurance status, household size, and costs. Use this table as a guide (call for personalized check):

*Exceptions apply. Confirm via (888) 941-3331 or online tool.[2][9] Household includes all living with you.[5][8]

Insurance Requirements

• Uninsured: Primary option for Foundation free drug.[1]
• Underinsured/Insured without ENSPRYNG coverage: Foundation help if costs unaffordable.[6]
• Commercially insured: Co-pay program for cost-sharing; Foundation if OOP too high.[program details][4]
• Medicare/Medicaid: Limited; no Foundation for Medicare. Check co-pay options separately.[4][7]
• No citizenship required; U.S. residents treated by U.S. physicians qualify.[6]

Step-by-Step Application Process

Applications are multiple methods; both Patient Consent Form and Prescriber Foundation Form are required.[1][6]

1. Check eligibility: Use online tool at gene.com/patients/patient-foundation/see-if-you-qualify or call (888) 941-3331 (Mon-Fri, 6am-5pm PT).[2][9]
2. Gather info: Household size, income, insurance details, deductible/OOP max.[5][8]
3. Complete forms:
   • Patient: Fill Patient Consent Form (English/Spanish) online or print.[1][5]
   • Doctor: Completes Prescriber Foundation Form.[6]
4. Submit together:

   Method	Details
   Online	eSubmit or My Patient Solutions (HCP account).[1][3]
   Phone	(844) 677-7964 or (888) 941-3331.[program details][2]
   Fax	833-999-4363.[1][6]
   Text	Photo to 650-877-1111.[1]
   Website	enspryng.com/financial-support/apply.html.[program details]

5. Wait for contact: Processed in ~5 business days; office/patient notified of outcome.[1][7]

No proof of income/appeals needed upfront; submit while appealing denials.[4]

Timeline and Delivery

• Processing: 5 business days after both forms received.[1]
• Approval notice: Phone contact to prescriber/patient.[1][8]
• Delivery: Shipped free to patient's home, participating pharmacy, or doctor's office.[program details][5]
• Duration: 1 year free meds; reauthorization required annually or upon insurance changes.[program details][7]
• Refills: Automatic if eligible; reverify yearly.[7]

Alternatives if Denied

• Appeal denial with doctor (no proof needed for initial app).[4]
• Other programs: Genentech Access Solutions for benefits check; state assistance; patient access networks (PAN Foundation, etc.).[2]
• Co-pay card: If commercial insurance qualifies.[program details]
• Biosimilars: None currently for ENSPRYNG.[program details]
• Call Foundation Specialist for local resources.[2]

Important Disclaimer

This guide is for informational purposes based on available program details as of latest updates. Eligibility, terms, and availability can change; always verify with Genentech at (888) 941-3331 or official sites. Not medical/financial advice—consult your doctor and advisor. Genentech reserves rights to modify/terminate programs. Medicare patients: Federal law prohibits coverage of co-pays in some cases.[1][2][4]