Enhertu

Indicated For

breast cancer, gastric cancer, NSCLC

About This Medication

# Daiichi Sankyo and AstraZeneca ENHERTU Patient Assistance Program Patient Guide: How to Get Enhertu (fam-trastuzumab deruxtecan-nxki) at Low or No Cost Enhertu (fam-trastuzumab deruxtecan-nxki) is a targeted cancer treatment, and the **Daiichi Sankyo and AstraZeneca ENHERTU Patient Assistance Program** offers it **free** to eligible uninsured, underinsured, or Medicare patients facing financial hardship. This guide explains eligibility, application steps, and support options in simple terms. ## About Enhertu (fam-trastuzumab deruxtecan-nxki) **Enhertu** is an intravenous infusion medication used to treat certain types of advanced cancers, including HER2-positive or HER2-low breast cancer, HER2-mutant non-small cell lung cancer (NSCLC), HER2-positive gastric cancer, and other solid tumors with specific HER2 status. It combines a monoclonal antibody (trastuzumab) with a chemotherapy drug (deruxtecan) in an antibody-drug conjugate (ADC) that targets and delivers treatment directly to cancer cells expressing HER2 protein. Administered every 3 weeks by a healthcare provider, Enhertu has shown strong results in clinical trials for patients who have progressed after prior therapies, but its list price exceeds $15,000 per dose, making assistance programs essential for access.[2] Always discuss with your oncologist if Enhertu is right for your diagnosis, as it requires confirmed HER2 status via testing and often prior treatments.[1] ## Who Qualifies for the Program? This program helps **patients experiencing financial difficulty** who meet these criteria: - **Uninsured, underinsured, or Medicare patients** (excludes those with private or government insurance covering Enhertu, other than Medicare). - **Income at or below a certain level** (exact thresholds not publicly published; call to verify based on your situation).[2] - **U.S. residents** (residency details not specified but typically required). - **Not receiving other assistance** for Enhertu. The program provides **free medication** (one dose per shipment) for up to 12 months, with re-enrollment possible. Medicare patients enroll on a calendar-year basis; uninsured on a rolling annual basis.[2] ## Income Eligibility Breakdown Specific income limits are **not published publicly** and depend on household size, medical expenses, and other factors. The program considers income "at or below a certain level," potentially allowing deductions for medical costs (details not published).[2] Here's a general overview based on similar programs (call **(833) 364-3788** for your exact eligibility): | Household Size | Estimated FPL % Threshold | Example Annual Income (2026) | Notes | |---|---|---|---| | Individual | ~400-500% FPL | Up to ~$60,000-$75,000 | Exact not published; call for assessment[2] | | Couple | ~400-500% FPL | Up to ~$80,000-$100,000 | Varies by state/circumstances[2] | | Family of 3 | ~400-500% FPL | Up to ~$100,000-$125,000 | Medical expenses may deduct[2] | | Family of 4 | ~400-500% FPL | Up to ~$120,000-$150,000 | Not guaranteed; program-specific[2] | **Tip:** Even if near thresholds, apply—exceptions for high medical costs are common. Income verification happens during enrollment.[2] ## Insurance Requirements - **Eligible:** Uninsured, underinsured (high copays/deductibles), or **Medicare patients** (Parts A/B/D) unable to afford Enhertu.[2] - **Not Eligible:** Patients with **private insurance** or **government coverage** (e.g., Medicaid, Tricare) that covers Enhertu, or those on other assistance programs.[2] - Medicare patients: Coverage limited; program bridges gaps but excludes full commercial coverage.[2] If insured, explore **ENHERTU4U** (same phone: 1-833-364-3788) for copay assistance up to $26,000/year or prior authorization help first.[3][4] ## Step-by-Step Application Process Applications accept **multiple methods** (phone, fax, mail); no online portal listed.[2] 1. **Contact the Program:** Call **(833) 364-3788** (Mon-Fri, business hours) to start. Discuss eligibility and get forms (English/Spanish PDFs).[2] 2. **Gather Documents:** - **Physician/state NPI or license.** - **Prescriber signature.** - Proof of income/financial hardship (e.g., tax returns, pay stubs—details via phone).[2] - Patient info, diagnosis, insurance status. 3. **Complete Form:** Doctor fills/signs; patient provides financials. Fax to **(833) 904-1851** or mail to PO Box 2355, Morristown, NJ 07962.[2] 4. **Submit:** Provider typically handles; allow 1-2 days prep. 5. **Eligibility Letter:** Sent upon approval.[2] **Provider Role:** Oncologist submits; shipped to their office. ## Timeline and Delivery - **Processing:** **0-1 week** from complete submission.[2] - **Delivery:** **Shipped free to provider** (1 dose per shipment).[2] - **Refills:** Call program to request; new app/financials every 12 months.[2] Expect medication at infusion center quickly post-approval. ## Alternatives if Denied or Ineligible - **ENHERTU4U Copay/Savings:** Up to $26,000/year for commercial insurance; call same number.[3][4][5] - **Other PAPs:** Check RxAssist.org or NeedyMeds for generics/biosimilars (none listed for Enhertu).[2] - **State Programs:** Medicaid expansion, cancer-specific aid. - **Appeals:** Resubmit with more financial proof; discuss denial reasons by phone. - **Manufacturer Bridge:** Short-term free supply via provider. No **biosimilar alternatives** available.[2] ## Important Disclaimer This guide is for informational purposes only and based on publicly available data as of 2026. Eligibility, terms, and availability can change—**always call (833) 364-3788** for latest details. Not medical/financial advice; consult your doctor and advisor. Program not guaranteed; RxAssist/RxVantage not liable.[2]

Program information last verified: March 23, 2026