ENHERTU

Indicated For

HER2-positive breast cancer, gastric cancer, gastroesophageal junction adenocarcinoma, non-small cell lung cancer

About This Medication

# ENHERTU4U Patient Guide: How to Get ENHERTU (fam-trastuzumab deruxtecan-nxki) at Low or No Cost ENHERTU4U is a comprehensive support program from Daiichi Sankyo and AstraZeneca designed to help eligible patients access and afford **ENHERTU**, a targeted therapy for certain advanced cancers like HER2-positive breast cancer and HER2-mutant non-small cell lung cancer (NSCLC).[1][3] ## About ENHERTU **ENHERTU (fam-trastuzumab deruxtecan-nxki)** is a prescription medicine given intravenously every three weeks to treat adults with specific types of cancer. It targets HER2-positive metastatic breast cancer (often in combination with pertuzumab for first-line treatment), HER2-low or ultra-low breast cancer after prior treatments, HER2-mutant metastatic NSCLC after prior therapy, and certain gastric cancers.[3] Your doctor will test your tumor to confirm if ENHERTU is appropriate. It's administered by a healthcare provider via IV infusion, with pre-medications to prevent nausea. Always discuss benefits, risks (including serious warnings like lung issues), and side effects with your doctor. Full details are in the Prescribing Information and Medication Guide available at ENHERTU4U.com.[1][3] ## Who Qualifies for ENHERTU4U? ENHERTU4U offers **multiple programs** to fit different situations: the **Patient Savings Program** (no income limits, pay as little as $0 per prescription up to $26,000 annually, covering drug costs and up to $100 per infusion in most states) and **Patient Assistance Programs** (for those with financial need).[1][2] It also connects to independent foundations. Your healthcare provider plays a key role in determining eligibility and starting the process.[1][6] ## Income Eligibility Breakdown The Patient Savings Program has **no income requirements**, making it accessible to many commercially insured patients.[1][2] Patient Assistance Programs require annual income at or below a certain level, but exact thresholds are not publicly disclosed—contact ENHERTU4U for details based on your household size.[1] | Program | Income Requirements | Key Benefits | |---------|---------------------|--------------| | **Patient Savings Program** | None | $0 copay per prescription; up to $26,000/year for drug + $100/infusion (excludes MA, MI, MN, RI for infusions) [1][2] | | **Patient Assistance Programs** | Annual income ≤ specific threshold (not disclosed; call for details) | Free or low-cost ENHERTU for uninsured/underinsured/Medicare patients in need [1][6] | | **Independent Foundations** | Varies by foundation | Additional grants; ENHERTU4U helps identify options [6] | ## Insurance Requirements Eligibility depends on your coverage: - **Patient Savings Program**: For patients with **commercial insurance** that doesn't cover the full cost. **Not eligible** if on Medicare Part B/D, Medicaid, Medigap, VA, or TRICARE.[1] - **Patient Assistance Programs**: For **uninsured, underinsured, or Medicare patients** facing financial hardship.[1] ENHERTU4U also provides **access support** to help your doctor navigate insurance prior authorizations and coverage appeals.[1][4][5] ## Step-by-Step Application Process 1. **Get Prescribed**: Discuss ENHERTU with your oncologist. They must confirm it's right for you via testing.[3] 2. **Contact ENHERTU4U**: Call **(833) 364-3788** (1-833-ENHERTU) or visit **www.ENHERTU4U.com**. Have your prescription ready.[1][2] 3. **Choose Your Program**: Staff will assess your insurance and finances to recommend Savings or Assistance.[1] 4. **Complete Application**: Applications are available **online** or by phone/mail. Your doctor may need to submit a Patient Authorization Form.[2] Provide proof of income/residency if applying for Assistance (exact docs confirmed during call).[1] 5. **Doctor Involvement**: Your provider handles prior auth and infusion details.[1][6] 6. **Approval Notification**: You'll be informed of status; benefits activate quickly for eligible patients.[1] Multiple application methods make it flexible—phone, web, or download forms from the site.[1][2] ## Timeline and Delivery Processing times vary but aim for quick access post-prescription. Savings Program copay cards activate rapidly; Assistance may take longer based on review. ENHERTU is **shipped to your doctor's office or directly to you** (confirm with program). Infusions occur every 21 days at a clinic.[1][3] Call for reauthorization before each cycle if needed. ## Alternatives if Denied or Ineligible - **Appeal Insurance Denial**: ENHERTU4U helps with prior auth support.[4][5] - **Independent Foundations**: Program connects you to charities for grants.[6] - **Other Manufacturer Programs**: Explore state assistance or generic options (no biosimilars noted). - **Discuss with Doctor**: Switch therapies or explore clinical trials. ENHERTU4U does **not guarantee** coverage or savings—terms apply.[5] ## Important Disclaimer This guide is for informational purposes only and not a substitute for medical or financial advice. Eligibility, benefits, and terms can change; always verify with ENHERTU4U at (833) 364-3788 or www.ENHERTU4U.com. Consult your healthcare provider for personalized guidance. ENHERTU has serious risks—review full Prescribing Information, including Boxed Warnings.[1][3] Program excludes certain states for infusions.[1][2] Word count: 928.

Program information last verified: March 30, 2026