Enhertu

Indicated For

HER2-positive metastatic gastric or gastroesophageal junction adenocarcinoma

About This Medication

# ENHERTU4U Patient Guide: How to Get Enhertu (fam-trastuzumab deruxtecan-nxki) at Low or No Cost Enhertu (fam-trastuzumab deruxtecan-nxki) is a prescription medicine used to treat certain types of cancers, including **HER2-positive breast cancer**, **HER2-mutant non-small cell lung cancer (NSCLC)**, **HER2-positive gastric cancer**, and **HER2-positive solid tumors** that have spread or cannot be removed by surgery. The **ENHERTU4U** program, offered by **Daiichi Sankyo**, provides multiple financial assistance options to help eligible patients pay **as little as $0** per prescription, up to **$26,000 per calendar year**, with **no income requirements** for participation.[1][4] ## About Enhertu Enhertu is an intravenous (IV) infusion given **every 3 weeks (21-day cycle)** by your healthcare provider. It targets **HER2-positive** cancers, helping to slow or stop cancer growth. Your doctor will test your tumor to confirm it's right for you. Before infusion, you'll receive medicines to prevent nausea and vomiting. Common uses include: - **HER2-positive metastatic breast cancer** (after other treatments or with pertuzumab as first-line). - **HER2-mutant NSCLC** (after prior treatments). - **HER2-positive gastric cancer** (after at least two prior treatments). - **Unresectable or metastatic HER2-positive (IHC 3+) solid tumors** with no satisfactory options.[3][5] Always discuss benefits, risks (including serious **Boxed Warnings** for lung and heart issues), and full Prescribing Information with your doctor. ## Who Qualifies for ENHERTU4U? ENHERTU4U offers **financial assistance** through programs like the **Patient Savings Program**, **Patient Assistance Programs**, and connections to **Independent Foundations**. Key perks: - Pay **$0** out-of-pocket for Enhertu (up to $26,000/year). - Up to **$100 per infusion** covered (not available in MA, MI, MN, RI).[1][4] - **No income requirements** – open to most patients with a valid prescription.[1][4] Your healthcare provider plays a key role in determining eligibility and accessing support. The program also helps navigate **insurance access** requirements.[1][2][3] ## Income Eligibility Breakdown Unlike many programs, ENHERTU4U has **no strict income thresholds**. Multiple options are available based on your situation. Contact the program for personalized details. | Household Size | Income Threshold | FPL % | Notes | |----------------|------------------|-------|-------| | Individual | None | None | No income requirements; multiple options available[1][4] | | Couple | None | None | Contact program/provider for eligibility[1] | | Family of 3 | None | None | Terms apply; foundations may have separate rules | | Family of 4 | None | None | Up to $26,000 annual benefit[1][4] | **Notes**: Eligibility depends on insurance, prescription, and state residency. Your doctor can guide you.[1][3] ## Insurance Requirements ENHERTU4U helps your provider understand your **insurance coverage** and requirements for Enhertu access. It **does not guarantee coverage** or cost savings.[5] Options work with most insurance, including commercial plans. For **Medicare** or government insurance, check specific program terms – savings may be limited. Download the **Patient Authorization Form** from ENHERTU4U.com for easier enrollment.[2] Contact (833) 364-3788 for insurance details.[1][3] ## Step-by-Step Application Process 1. **Get Prescribed**: Ask your healthcare provider to prescribe Enhertu and discuss ENHERTU4U.[1] 2. **Contact ENHERTU4U**: Call **1-833-ENHERTU (833-364-3788)** Monday-Friday, 8 AM-8 PM ET, or visit www.ENHERTU4U.com.[1][2] 3. **Choose Assistance**: Select from Patient Savings, Assistance Programs, or Foundations. Your provider may initiate.[3] 4. **Provide Info**: Share prescription details, insurance info, and sign forms (downloadable online).[2] 5. **Approval**: Program reviews quickly; start benefits upon approval.[1] 6. **Receive Meds**: Infused at your provider's office; savings applied at pharmacy/infusion.[4] Applications can be submitted via **phone, website, or provider**. No specific documents listed – program guides you.[1] ## Timeline and Delivery Processing time varies; call for status. Once approved, benefits apply **immediately** to prescriptions/infusions. Enhertu is **delivered via IV at your doctor's office** – no home delivery needed. Annual benefit renews each calendar year. Refills follow your treatment cycle (every 21 days).[3][4] ## Alternatives if Denied or Ineligible - **Independent Foundations**: ENHERTU4U connects you to others.[1][2] - **Other Patient Assistance**: General programs like NeedyMeds or RxAssist. - **State Programs**: Check local Medicaid or charity care. - **Generic/Biosimilars**: None available yet for Enhertu. - **Discuss with Doctor**: Switch treatments or appeal insurance. If denied, reapply or explore foundations via the helpline.[1] ## Disclaimer This guide is for informational purposes only and not a substitute for medical or financial advice. ENHERTU4U terms apply; eligibility not guaranteed. Consult your healthcare provider and the program at 1-833-364-3788 or ENHERTU4U.com for latest details. See full Prescribing Information, Boxed Warnings, and Medication Guide. Daiichi Sankyo does not endorse third-party sites. Word count: 912.

Program information last verified: March 30, 2026