Endari

Indicated For

sickle cell disease

About This Medication

# Endari Support Program Patient Guide: How to Get Endari at Low or No Cost Endari (L-glutamine oral powder) is a prescription medication indicated to reduce acute complications of sickle cell disease (SCD) in adults and children 5 years and older. The **Endari Support Program** from **Emmaus Life Sciences** helps eligible U.S. patients access Endari at no or minimal cost if they meet income limits and insurance criteria.[1][2] ## About Endari and Sickle Cell Disease Sickle cell disease is a genetic blood disorder where red blood cells become sickle-shaped, leading to pain crises, acute chest syndrome, and other complications. Endari works by replenishing L-glutamine, an amino acid that helps red blood cells resist oxidative stress, stay flexible, and carry oxygen better. Approved by the FDA in 2017, it's the first new SCD treatment in nearly 20 years.[3][8] **Common side effects** include constipation, nausea, headache, abdominal pain, cough, hand/foot pain, back pain, and chest pain. Rare effects leading to discontinuation in studies: hypersplenism, abdominal pain, indigestion, burning sensation, hot flash. Always discuss risks with your doctor.[1][4][8] Endari dosing is weight-based: <30 kg (1 packet twice daily), 30-65 kg (2 packets), >65 kg (3 packets). Mix powder in 8 oz of cold or room-temperature food/drink; do not heat or add to hot foods.[5][7] ## Who Qualifies for the Endari Support Program? You may qualify if:[1] - You are a **U.S. resident**. - Your **household meets certain income limits** (exact thresholds not publicly specified; call to verify).[1] - **And one of these applies**: - You are **uninsured**. - You have **commercial/private insurance** that does **not cover Endari**. **Government insurance** (e.g., Medicare, Medicaid) patients are **ineligible** for the copay program.[1][2] This program is not government-funded or an insurance plan; Emmaus can modify or end it anytime without notice.[1] ## Income Eligibility Breakdown Specific income thresholds (e.g., % of Federal Poverty Level) are not detailed online; eligibility requires "certain household income limits." Contact the program at (855) 723-5646 for personalized assessment based on household size and income.[1] Here's a general table of common patient assistance income structures (for reference; confirm with program): | Household Size | Typical Max Annual Income (e.g., 400-500% FPL)* | |----------------|------------------------------------------------| | 1 (Individual) | $60,000 - $75,000 | | 2 (Couple) | $81,000 - $101,000 | | 3 | $102,000 - $127,000 | | 4 | $122,000 - $153,000 | *Estimates only; actual limits vary. Provide proof of income (tax returns, pay stubs) during application.[1] ## Insurance Requirements - **Eligible**: Uninsured or commercial/private insurance **not covering Endari**.[1] - **Ineligible**: Government insurance (Medicare/Medicaid) for copay assistance; separate copay program exists for some commercial insurance but limited to financially eligible patients.[2][4] If insured but denied coverage, submit denial letter. Your doctor may need to confirm medical necessity (e.g., 2+ pain crises/year, hydroxyurea use/intolerance).[5] ## Step-by-Step Application Process 1. **Verify Eligibility**: Call (855) 723-5646 or visit https://www.endarirx.com/esp-registration. Answer eligibility questions online.[1][4] 2. **Gather Documents**: - **Proof of income** (e.g., tax return, W-2, pay stubs, SSI award).[1] - **Proof of residency** (e.g., utility bill, lease).[1] - **Insurance information** (card, denial letter if applicable).[1] 3. **Complete Application**: Online at https://www.endarirx.com/esp-registration or call for help. Include physician details and prescription.[1] 4. **Physician Submits Prescription**: Doctor sends Rx to program's Specialty Pharmacy (e.g., TheraCom/Lash Group).[1][3] 5. **Approval Notification**: If approved, Specialty Pharmacy contacts you.[1] Applications are **online** primarily; phone support available.[1] ## Timeline and Delivery Processing time not specified; expect contact from pharmacy post-approval. Medication **shipped directly via Specialty Pharmacy** monthly. **Reauthorization required** periodically—submit updated docs showing continued need.[1][5] ## Alternatives if Denied - **Appeal**: Provide more income/residency proof or insurance denial.[1] - **Copay Program**: If commercial insurance covers but high copay, apply separately via copay@endarirx.com or (855) 723-5646 (financially eligible only).[2][4] - **Other Assistance**: PAN Foundation, HealthWell Foundation for SCD; state programs; generic L-glutamine (but Endari is prescription; prior auth often requires OTC failure).[3][5][7] - **No biosimilars** available.[program data] - Discuss with doctor: hydroxyurea or other SCD therapies. ## Important Disclaimer This guide is for informational purposes only and not medical/financial advice. Eligibility, benefits, and program terms can change; Emmaus may discontinue anytime.[1] Consult your doctor for treatment suitability. Verify details directly with Endari Support Program at (855) 723-5646 or https://www.endarirx.com. Report side effects to FDA at 1-800-FDA-1088.[8]

Program information last verified: March 30, 2026